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25.01.2016 | Magnetic Resonance

Feasibility of test-bolus DCE-MRI using CAIPIRINHA-VIBE for the evaluation of pancreatic malignancies

verfasst von: Jimi Huh, Yoonseok Choi, Dong-Cheol Woo, Nieun Seo, Bohyun Kim, Chang Kyung Lee, In Seong Kim, Dominik Nickel, Kyung Won Kim

Erschienen in: European Radiology | Ausgabe 11/2016

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Abstract

Objectives

To evaluate the feasibility of test-bolus dynamic contrast-enhanced (DCE) MRI with CAIPIRINHA-VIBE for pancreatic malignancies.

Methods

Thirty-two patients underwent DCE-MRI with CAIPIRINHA-VIBE after injection of 2 mL gadolinium. From the resulting time–intensity curve (TIC), we estimated the arterial (AP) and portal venous phase (PVP) scan timing for subsequent multiphasic MRI. DCE-MRI perfusion maps were generated, and perfusion parameters were calculated. The image quality was rated on a 5-point scale (1: poor, 5: excellent). Goodness-of-fit of the TIC was evaluated by Pearson’s χ² test.

Results

Test-bolus DCE-MRIs with high temporal (3 s) and spatial resolution (1 × 1 × 4 mm³) were acquired with good-quality perfusion maps of Ktrans and iAUC (mean score 4.313 ± 0.535 and 4.125 ± 0.554, respectively). The mean χ² values for fitted TICs were 0.115 ± 0.082 for the pancreatic parenchyma and 0.784 ± 0.074 for pancreatic malignancies, indicating an acceptable goodness-of-fit. Test-bolus DCE-MRI was highly accurate in estimating the proper timing of AP (90.6 %) and PVP (100 %) of subsequent multiphasic MRI. Between pancreatic adenocarcinomas and neuroendocrine tumours, there were significant differences in the Ktrans (0.073 ± 0.058 vs. 0.308 ± 0.062, respectively; p = 0.007) and iAUC (1.501 ± 0.828 vs. 3.378 ± 0.378, respectively; p = 0.045).

Conclusions

Test-bolus DCE-MRI using CAIPIRINHA-VIBE is feasible for incorporating perfusion analysis of pancreatic tumours into routine multiphasic MRI.

Key Points

• Test-bolus DCE-MRI using CAIPIRINHA-VIBE is feasible for perfusion analysis of pancreatic tumours.

• CAIPIRINHA-VIBE enables DCE-MRI with high temporal and spatial resolution.

• Test-bolus DCE-MRI is highly accurate in estimating the proper timing of multiphasic MRI.

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Titel: Feasibility of test-bolus DCE-MRI using CAIPIRINHA-VIBE for the evaluation of pancreatic malignancies
verfasst von: Jimi Huh
Yoonseok Choi
Dong-Cheol Woo
Nieun Seo
Bohyun Kim
Chang Kyung Lee
In Seong Kim
Dominik Nickel
Kyung Won Kim
Publikationsdatum: 25.01.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4209-6

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Feasibility of test-bolus DCE-MRI using CAIPIRINHA-VIBE for the evaluation of pancreatic malignancies

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Objectives

Methods

Results

Conclusions

Key Points

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