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Journal of Gastroenterology
Erschienen in: Journal of Gastroenterology 5/2016

20.02.2016 | Review

Fecal calprotectin: its scope and utility in the management of inflammatory bowel disease

verfasst von: Shapur Ikhtaire, Mohammad Sharif Shajib, Walter Reinisch, Waliul Islam Khan

Erschienen in: Journal of Gastroenterology | Ausgabe 5/2016

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Abstract

Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endoscopic techniques. Therefore, a simple, noninvasive, inexpensive, and effective test would be of utmost importance in clinical practice. Fecal calprotectin (FC) is considered to be a reliable biomarker that fulfills these criteria. FC can detect intestinal inflammation, and its level correlates well with macroscopic and histological inflammation as detected by colonoscopy and biopsies, respectively. FC has a decent diagnostic accuracy for differentiating organic diseases and functional disorders because of its excellent negative predictive value in ruling out inflammatory bowel disease (IBD) in symptomatic undiagnosed patients. There is accumulating evidence that FC has been effectively used to monitor the natural course of IBD, to predict relapse, and to see the response to treatment. This novel biomarker has the ability to assess mucosal healing (MH), which is a therapeutic goal in IBD management. A literature search was carried out using PubMed with the keywords FC, IBD, intestinal inflammation, and MH. In our review, we provide an overview of the utility and scope of FC as a biomarker in patients with IBD as well as undiagnosed patients with lower gastrointestinal symptoms.
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Metadaten
Titel
Fecal calprotectin: its scope and utility in the management of inflammatory bowel disease
verfasst von
Shapur Ikhtaire
Mohammad Sharif Shajib
Walter Reinisch
Waliul Islam Khan
Publikationsdatum
20.02.2016
Verlag
Springer Japan
Erschienen in
Journal of Gastroenterology / Ausgabe 5/2016
Print ISSN: 0944-1174
Elektronische ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-016-1182-4

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