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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Gastroenterology 1/2014

Fecal lactoferrin in discriminating inflammatory bowel disease from Irritable bowel syndrome: a diagnostic meta-analysis

Zeitschrift:
BMC Gastroenterology > Ausgabe 1/2014
Autoren:
Xing-lu Zhou, Wen Xu, Xiao-xiao Tang, Lai-sheng Luo, Jiang-feng Tu, Chen-jing Zhang, Xiang Xu, Qin-dong Wu, Wen-sheng Pan
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-230X-14-121) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

WP, XX and QWcontributed to the conception, design and final approval of the submitted version. XZ, WX and XT developed the literature search, carried out the extraction of data, assisted in the critical appraisal of included studies and assisted in writing up. LL, JT and CZ carried out the statistical analysis of studies. All authors read and approved the final manuscript.

Abstract

Background

To perform a meta-analysis evaluating the diagnostic ability of fecal lactoferrin (FL) to distinguish inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS).

Methods

The Medline, EMBASE, Web of Science, Cochrane library and CNKI databases were systematically searched for studies that used FL concentrations to distinguish between IBD and IBS. The sensitivity, specificity, and other diagnostic indexes of FL were pooled using a random-effects model.

Results

Seven studies, involving 1012 patients, were eligible for inclusion. In distinguishing IBD from IBS, FL had a pooled sensitivity of 0.78 (95% confidence interval [CI]: 0.75, 0.82), a specificity of 0.94 (95% CI: 0.91, 0.96), a positive likelihood ratio of 12.31 (95% CI: 5.93, 29.15), and a negative likelihood ratio of 0.23 (95% CI: 0.18, 0.29). The area under the summary receiver-operating characteristic curve was 0.94 (95% CI: 0.90, 0.98) and the diagnostic odds ratio was 52.65 (95% CI: 25.69, 107.91).

Conclusions

FL, as a noninvasive and simple marker, is useful in differentiating between IBD and IBS.
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