Skip to main content
Erschienen in: Breast Cancer Research 5/2010

01.10.2010 | Viewpoint

Ferroportin and hepcidin: a new hope in diagnosis, prognosis, and therapy for breast cancer

verfasst von: Igor P Pogribny

Erschienen in: Breast Cancer Research | Ausgabe 5/2010

Einloggen, um Zugang zu erhalten

Abstract

Breast cancer is the most prevalent malignancy in women. The success of breast cancer treatment relies on the ability to detect the disease and correct molecular abnormalities at an early stage of disease development. A recent article describes a marked decrease in the levels of ferroportin in breast cancer. More importantly, the presented results demonstrate convincingly the incredible diagnostic and prognostic value of ferroportin and hepcidin gene expression in breast cancer and suggest that determination of these two molecular markers may be used as guidance toward individualized therapy for breast cancer patients.
Literatur
1.
Zurück zum Zitat Hentze MW, Muckenthaler MU, Galy B, Camaschella C: Two to tango: regulation of mammalian iron metabolism. Cell. 2010, 142: 24-38. 10.1016/j.cell.2010.06.028.CrossRefPubMed Hentze MW, Muckenthaler MU, Galy B, Camaschella C: Two to tango: regulation of mammalian iron metabolism. Cell. 2010, 142: 24-38. 10.1016/j.cell.2010.06.028.CrossRefPubMed
2.
Zurück zum Zitat Richardson DR, Ponka P: The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997, 1331: 1-40.CrossRefPubMed Richardson DR, Ponka P: The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997, 1331: 1-40.CrossRefPubMed
3.
Zurück zum Zitat Kwok JC, Richardson DR: The iron metabolism of neoplastic cells: alterations that facilitate proliferation?. Crit Rev Oncol Hematol. 2002, 42: 65-78. 10.1016/S1040-8428(01)00213-X.CrossRefPubMed Kwok JC, Richardson DR: The iron metabolism of neoplastic cells: alterations that facilitate proliferation?. Crit Rev Oncol Hematol. 2002, 42: 65-78. 10.1016/S1040-8428(01)00213-X.CrossRefPubMed
4.
Zurück zum Zitat Shpyleva SI, Tryndyak VP, Kovalchuk O, Starlard-Davenport A, Chekhun VP, Beland FA, Pogribny IP: Role of ferritin alterations in human breast cancer cells. Breast Cancer Res Treat. 2010 Shpyleva SI, Tryndyak VP, Kovalchuk O, Starlard-Davenport A, Chekhun VP, Beland FA, Pogribny IP: Role of ferritin alterations in human breast cancer cells. Breast Cancer Res Treat. 2010
5.
Zurück zum Zitat Lieghr JG, Jones JS: Role of iron in estrogen-induced cancer. Curr Med Chem. 2001, 8: 839-849.CrossRef Lieghr JG, Jones JS: Role of iron in estrogen-induced cancer. Curr Med Chem. 2001, 8: 839-849.CrossRef
6.
Zurück zum Zitat Kabat GC, Rohan TE: Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis. Cancer Causes Control. 2007, 18: 1047-1053. 10.1007/s10552-007-9058-9.CrossRefPubMed Kabat GC, Rohan TE: Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis. Cancer Causes Control. 2007, 18: 1047-1053. 10.1007/s10552-007-9058-9.CrossRefPubMed
8.
Zurück zum Zitat Jiang XP, Elliot RL, Head JF: Manipulation of iron transported genes results in the suppression of human and mouse mammary adenocarcinomas. Anticancer Res. 2010, 30: 759-765.PubMed Jiang XP, Elliot RL, Head JF: Manipulation of iron transported genes results in the suppression of human and mouse mammary adenocarcinomas. Anticancer Res. 2010, 30: 759-765.PubMed
9.
Zurück zum Zitat Pinnix ZK, Miller LD, Wang W, D'Agostino R, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, Torti SV, Torti FM: Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med. 2010, 2: 43ra56 Pinnix ZK, Miller LD, Wang W, D'Agostino R, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, Torti SV, Torti FM: Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med. 2010, 2: 43ra56
10.
Zurück zum Zitat Fleming MD: The regulation of hepcidin and its effects on systemic and cellular iron metabolism. Hematology Am Soc Hematol Educ Program. 2008, 151-158. Fleming MD: The regulation of hepcidin and its effects on systemic and cellular iron metabolism. Hematology Am Soc Hematol Educ Program. 2008, 151-158.
11.
Zurück zum Zitat Franchini M, Montagnana M, Lippi G: Hepcidin and iron metabolism: from laboratory to clinical implications. Clin Chim Acta. 2010, 411: 1565-1569. 10.1016/j.cca.2010.07.003.CrossRefPubMed Franchini M, Montagnana M, Lippi G: Hepcidin and iron metabolism: from laboratory to clinical implications. Clin Chim Acta. 2010, 411: 1565-1569. 10.1016/j.cca.2010.07.003.CrossRefPubMed
12.
Zurück zum Zitat Richardson DR, Kalinowski DS, Lau S, Jansson PJ, Lovejoy DB: Cancer cell iron metabolism and the development of potent chelators as anti-tumour agents. Biochim Biophys Acta. 2009, 1790: 702-717.CrossRefPubMed Richardson DR, Kalinowski DS, Lau S, Jansson PJ, Lovejoy DB: Cancer cell iron metabolism and the development of potent chelators as anti-tumour agents. Biochim Biophys Acta. 2009, 1790: 702-717.CrossRefPubMed
13.
Zurück zum Zitat Courselaud B, Pigeon C, Inoue Y, Inoue J, Gonzalez FJ, Leroyer P, Gilot D, Boudjema K, Guguen-Guillouzo C, Brissot P, Loréal O, Ilyin G: C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem. 2002, 277: 41163-41170. 10.1074/jbc.M202653200.CrossRefPubMed Courselaud B, Pigeon C, Inoue Y, Inoue J, Gonzalez FJ, Leroyer P, Gilot D, Boudjema K, Guguen-Guillouzo C, Brissot P, Loréal O, Ilyin G: C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem. 2002, 277: 41163-41170. 10.1074/jbc.M202653200.CrossRefPubMed
14.
Zurück zum Zitat Sow FB, Alvarez GR, Gross RP, Satoskar AR, Schlesinger LS, Zwilling BS, Lafuse WP: Role of STAT1, NF-kappaB, and C/EBPbeta in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-gamma. J Leukoc Biol. 2009, 86: 1247-1258. 10.1189/jlb.1208719.CrossRefPubMed Sow FB, Alvarez GR, Gross RP, Satoskar AR, Schlesinger LS, Zwilling BS, Lafuse WP: Role of STAT1, NF-kappaB, and C/EBPbeta in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-gamma. J Leukoc Biol. 2009, 86: 1247-1258. 10.1189/jlb.1208719.CrossRefPubMed
Metadaten
Titel
Ferroportin and hepcidin: a new hope in diagnosis, prognosis, and therapy for breast cancer
verfasst von
Igor P Pogribny
Publikationsdatum
01.10.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 5/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2641

Weitere Artikel der Ausgabe 5/2010

Breast Cancer Research 5/2010 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.