Skip to main content
Erschienen in: Gastro-News 5/2019

13.09.2019 | Fettleber | fortbildung

Hepatologie — Teil 5 : Ernährung und NAFLD

Welchen Einfluss haben Ernährung und Genussmittel auf die Fettleber?

verfasst von: Prof. Dr. med. Claus Niederau

Erschienen in: Gastro-News | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Ernährung hat einen entscheidenden Einfluss auf die Entwicklung einer nicht alkoholischen Fettlebererkrankung. Während das Risiko durch hohe Gesamtkalorienzufuhr und erhöhten Kohlenhydratkonsum grundsätzlich steigt, ist die Gefahr durch andere Nahrungs- und Genussmittel aber nicht immer so eindeutig, wie oft vermutet.
Literatur
1.
Zurück zum Zitat Roeb E, Steffen HM, Bantel H, et al. S2k-Leitlinie. Nicht alkoholische Fettlebererkrankung. Z Gastroenterol. 2015; 53: 668–723.PubMedCrossRef Roeb E, Steffen HM, Bantel H, et al. S2k-Leitlinie. Nicht alkoholische Fettlebererkrankung. Z Gastroenterol. 2015; 53: 668–723.PubMedCrossRef
2.
Zurück zum Zitat Oddy WH, Herbison CE, Jacoby P, et al. The Western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence. Am J Gastroenterol. 2013; 108: 778–85.PubMedCrossRef Oddy WH, Herbison CE, Jacoby P, et al. The Western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence. Am J Gastroenterol. 2013; 108: 778–85.PubMedCrossRef
3.
Zurück zum Zitat Chung M, Ma J, Patel K, et al. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. Am J Clin Nutr. 2014;100:833–49.PubMedPubMedCentralCrossRef Chung M, Ma J, Patel K, et al. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. Am J Clin Nutr. 2014;100:833–49.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Chiu S, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr. 2014;68:416–23.PubMedPubMedCentralCrossRef Chiu S, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr. 2014;68:416–23.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Jegatheesan P, De Bandt JP. Fructose and NAFLD: The multifaceted aspects of fructose metabolism. Nutrients. 2017;9. pii: E230.PubMedCrossRef Jegatheesan P, De Bandt JP. Fructose and NAFLD: The multifaceted aspects of fructose metabolism. Nutrients. 2017;9. pii: E230.PubMedCrossRef
6.
Zurück zum Zitat Jensen T, Abdelmalek MF, Sullivan S, et al. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;65:1063–1075.CrossRef Jensen T, Abdelmalek MF, Sullivan S, et al. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;65:1063–1075.CrossRef
7.
Zurück zum Zitat Dehghan M, Mente A, Zhang X. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. Lancet. 2017;390:2050–2062.PubMedCrossRef Dehghan M, Mente A, Zhang X. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. Lancet. 2017;390:2050–2062.PubMedCrossRef
8.
Zurück zum Zitat Shi D, Chen J, Wang J, Yao J, Huang Y, Zhang G, Bao Z. Circadian clock genes in the metabolism of Non-alcoholic Fatty Liver Disease. Front Physiol. 2019;10:423PubMedPubMedCentralCrossRef Shi D, Chen J, Wang J, Yao J, Huang Y, Zhang G, Bao Z. Circadian clock genes in the metabolism of Non-alcoholic Fatty Liver Disease. Front Physiol. 2019;10:423PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Kant AK, Graubard BI. Association of self-reported sleep duration with eating behaviors of American adults: NHANES 2005-2010. Am J Clin Nutr. 2014;100:938–47.PubMedPubMedCentralCrossRef Kant AK, Graubard BI. Association of self-reported sleep duration with eating behaviors of American adults: NHANES 2005-2010. Am J Clin Nutr. 2014;100:938–47.PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Hunsberger M, Mehlig K, Börnhorst C, et al. Dietary carbohydrate and nocturnal sleep duration in relation to children's BMI: Findings from the IDEFICS study in eight European countries. Nutrients. 2015;7:10223–36.PubMedPubMedCentralCrossRef Hunsberger M, Mehlig K, Börnhorst C, et al. Dietary carbohydrate and nocturnal sleep duration in relation to children's BMI: Findings from the IDEFICS study in eight European countries. Nutrients. 2015;7:10223–36.PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Crippa A, Discacciati A, Larsson SC, et al. Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. Am J Epidemiol. 2014;180:763–75.PubMedCrossRef Crippa A, Discacciati A, Larsson SC, et al. Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. Am J Epidemiol. 2014;180:763–75.PubMedCrossRef
12.
Zurück zum Zitat Zhao Y, Wu K, Zheng J, et al. Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis. Public Health Nutr. 2015;18:1282–91.PubMedCrossRef Zhao Y, Wu K, Zheng J, et al. Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis. Public Health Nutr. 2015;18:1282–91.PubMedCrossRef
13.
Zurück zum Zitat Simon TG, Trejo MEP, Zeb I, et al. Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis. Metabolism. 2017;75:1–5.PubMedPubMedCentralCrossRef Simon TG, Trejo MEP, Zeb I, et al. Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis. Metabolism. 2017;75:1–5.PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Godos J, Micek A, Marranzano M, et al. Coffee consumption and risk of biliary tract cancers and liver cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies. Nutrients. 2017;9:9.CrossRef Godos J, Micek A, Marranzano M, et al. Coffee consumption and risk of biliary tract cancers and liver cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies. Nutrients. 2017;9:9.CrossRef
15.
Zurück zum Zitat Cardin R, Piciocchi M, Martines D, et al. Effects of coffee consumption in chronic hepatitis C: a randomized controlled trial. Dig Liver Dis. 2013;45:499–504.PubMedCrossRef Cardin R, Piciocchi M, Martines D, et al. Effects of coffee consumption in chronic hepatitis C: a randomized controlled trial. Dig Liver Dis. 2013;45:499–504.PubMedCrossRef
16.
Zurück zum Zitat Hodge A, Lim S, Goh E, Wong O, et al. Coffee intake is associated with a lower liver stiffness in patients with non-alcoholic fatty liver disease, hepatitis c, and hepatitis B. Nutrients. 2017;9:1.CrossRef Hodge A, Lim S, Goh E, Wong O, et al. Coffee intake is associated with a lower liver stiffness in patients with non-alcoholic fatty liver disease, hepatitis c, and hepatitis B. Nutrients. 2017;9:1.CrossRef
17.
Zurück zum Zitat Setiawan VW, Porcel J, Wei P, et al. Coffee drinking and alcoholic and nonalcoholic fatty liver diseases and viral hepatitis in the multiethnic cohort. Clin Gastroenterol Hepatol. 2017;15:1305–7.PubMedPubMedCentralCrossRef Setiawan VW, Porcel J, Wei P, et al. Coffee drinking and alcoholic and nonalcoholic fatty liver diseases and viral hepatitis in the multiethnic cohort. Clin Gastroenterol Hepatol. 2017;15:1305–7.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Catalano D, Martines M, Marchesini G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844–50.CrossRef Catalano D, Martines M, Marchesini G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844–50.CrossRef
19.
Zurück zum Zitat Shokouh P, Jeppesen PB, Hermansen K, et al. A combination of coffee compounds shows insulin-sensitizing and hepatoprotective effects in a rat model of diet-induced metabolic syndrome. Nutrients. 2017;10:10. pii: E1547CrossRef Shokouh P, Jeppesen PB, Hermansen K, et al. A combination of coffee compounds shows insulin-sensitizing and hepatoprotective effects in a rat model of diet-induced metabolic syndrome. Nutrients. 2017;10:10. pii: E1547CrossRef
20.
Zurück zum Zitat Birerdinc A, Stepanova M, Pawloski L, et al. Caffeine is protective in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2012;35:76–82.PubMedCrossRef Birerdinc A, Stepanova M, Pawloski L, et al. Caffeine is protective in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2012;35:76–82.PubMedCrossRef
21.
Zurück zum Zitat Freedman N, Park Y, Abnet C, et al. Association of coffee drinking with total and cause-specific mortality. Engl J Med. 2012;366:1891–904.CrossRef Freedman N, Park Y, Abnet C, et al. Association of coffee drinking with total and cause-specific mortality. Engl J Med. 2012;366:1891–904.CrossRef
22.
Zurück zum Zitat Gutierrez-Grobe Y, Chavez-Tapia N, Sanchez-Valle V, et al. High coffee intake is associated with lower grade nonalcoholic fatty liver disease: the role of peripheral antioxidant activity. Ann Hepatol. 2012;11:350–5.PubMedCrossRef Gutierrez-Grobe Y, Chavez-Tapia N, Sanchez-Valle V, et al. High coffee intake is associated with lower grade nonalcoholic fatty liver disease: the role of peripheral antioxidant activity. Ann Hepatol. 2012;11:350–5.PubMedCrossRef
23.
Zurück zum Zitat Molloy J, Calcagno C, Williams C, et al. Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. Hepatology. 2012;55:429–36.PubMedCrossRef Molloy J, Calcagno C, Williams C, et al. Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. Hepatology. 2012;55:429–36.PubMedCrossRef
24.
Zurück zum Zitat Anty R, Marjoux S, Iannelli A, et al. Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery. J Hepatol. 2012;57:1090–6.PubMedCrossRef Anty R, Marjoux S, Iannelli A, et al. Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery. J Hepatol. 2012;57:1090–6.PubMedCrossRef
25.
Zurück zum Zitat Mitchell D, Knight C, Hockenberry J, et al. Beverage caffeine intakes in the U.S. Food Chem Toxicol. 2004;63:136–42.CrossRef Mitchell D, Knight C, Hockenberry J, et al. Beverage caffeine intakes in the U.S. Food Chem Toxicol. 2004;63:136–42.CrossRef
26.
Zurück zum Zitat Bambha K, Wilson LA, Unalp A, et al. Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis. Liver Int. 2014;34:1250–8.PubMedCrossRef Bambha K, Wilson LA, Unalp A, et al. Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis. Liver Int. 2014;34:1250–8.PubMedCrossRef
27.
Zurück zum Zitat Graeter T, Niedermayer PC, Mason RA, et al. EMIL-Study group. Coffee consumption and NAFLD: a community based study on 1223 subjects. BMC Res Notes. 2015 3;8:640.CrossRef Graeter T, Niedermayer PC, Mason RA, et al. EMIL-Study group. Coffee consumption and NAFLD: a community based study on 1223 subjects. BMC Res Notes. 2015 3;8:640.CrossRef
28.
Zurück zum Zitat Zelber-Sagi S, Salomone F, Webb M, et al. Coffee consumption and nonalcoholic fatty liver onset: A prospective study in the general population. Transl. Res 2015;165:428–36.PubMedCrossRef Zelber-Sagi S, Salomone F, Webb M, et al. Coffee consumption and nonalcoholic fatty liver onset: A prospective study in the general population. Transl. Res 2015;165:428–36.PubMedCrossRef
29.
Zurück zum Zitat Barros RK, Cotrim HP, Daltro C, et al. Nonalcoholic steatohepatitis in morbid obese patients: coffee consumption vs. disease severity. Ann Hepatol. 2016;15:350–5.PubMedCrossRef Barros RK, Cotrim HP, Daltro C, et al. Nonalcoholic steatohepatitis in morbid obese patients: coffee consumption vs. disease severity. Ann Hepatol. 2016;15:350–5.PubMedCrossRef
32.
Zurück zum Zitat Veronese N, Notarnicola M, Cisternino AM, et al. Coffee intake and liver steatosis: A population study in a mediterranean area. Nutrients. 2018;10:1.CrossRef Veronese N, Notarnicola M, Cisternino AM, et al. Coffee intake and liver steatosis: A population study in a mediterranean area. Nutrients. 2018;10:1.CrossRef
33.
Zurück zum Zitat Wijarnpreecha K, Thongprayoon C, Ungprasert P. Coffee consumption and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2017;29: e8–12.PubMedCrossRef Wijarnpreecha K, Thongprayoon C, Ungprasert P. Coffee consumption and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2017;29: e8–12.PubMedCrossRef
34.
Zurück zum Zitat Shen H, Rodriguez AC, Shiani A, et al. Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis. Therap Adv Gastroenterol. 2016;9:113–20.PubMedPubMedCentralCrossRef Shen H, Rodriguez AC, Shiani A, et al. Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis. Therap Adv Gastroenterol. 2016;9:113–20.PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Marventano S, Salomone F, Godos J, et al. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. Clin Nutr. 2016;35:1269–81.PubMedCrossRef Marventano S, Salomone F, Godos J, et al. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. Clin Nutr. 2016;35:1269–81.PubMedCrossRef
36.
Zurück zum Zitat Saab S, Mallam D, Cox GA, et al. Impact of coffee on liver diseases: a systematic review. Liver Int. 2014;34:495–504.PubMedCrossRef Saab S, Mallam D, Cox GA, et al. Impact of coffee on liver diseases: a systematic review. Liver Int. 2014;34:495–504.PubMedCrossRef
37.
Zurück zum Zitat Kennedy OJ, Roderick P, Buchanan R, et al. Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis. Aliment Pharmacol Ther. 2016;43:562–74.PubMedCrossRef Kennedy OJ, Roderick P, Buchanan R, et al. Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis. Aliment Pharmacol Ther. 2016;43:562–74.PubMedCrossRef
38.
Zurück zum Zitat Alferink LJM, Kiefte-de Jong JC, Murad DS. Potential mechanisms underlying the role of coffee in liver health. Semin Liver Dis. 2018;38:193–214.PubMedCrossRef Alferink LJM, Kiefte-de Jong JC, Murad DS. Potential mechanisms underlying the role of coffee in liver health. Semin Liver Dis. 2018;38:193–214.PubMedCrossRef
39.
Zurück zum Zitat Salomone F, Li Volti G, Vitaglione P, et al. Coffee enhances the expression of chaperones and antioxidant proteins in rats with nonalcoholic fatty liver disease. Transl Res. 2014;163:593–602.PubMedCrossRef Salomone F, Li Volti G, Vitaglione P, et al. Coffee enhances the expression of chaperones and antioxidant proteins in rats with nonalcoholic fatty liver disease. Transl Res. 2014;163:593–602.PubMedCrossRef
40.
Zurück zum Zitat Watanabe S, Takahashi T, Ogawa H, et al. Daily coffee intake inhibits pancreatic beta cell damage and nonalcoholic steatohepatitis in a mouse model of spontaneous metabolic syndrome, tsumura-suzuki obese diabetic mice. Metab Synd. Relat Disord. 2017;15:170–7.CrossRef Watanabe S, Takahashi T, Ogawa H, et al. Daily coffee intake inhibits pancreatic beta cell damage and nonalcoholic steatohepatitis in a mouse model of spontaneous metabolic syndrome, tsumura-suzuki obese diabetic mice. Metab Synd. Relat Disord. 2017;15:170–7.CrossRef
41.
Zurück zum Zitat HVS KV, Patel DKS. Biomechanism of chlorogenic acid complex mediated plasma free fatty acid metabolism in rat liver. BMC Complement Altern Med. 2016 5;16:274. HVS KV, Patel DKS. Biomechanism of chlorogenic acid complex mediated plasma free fatty acid metabolism in rat liver. BMC Complement Altern Med. 2016 5;16:274.
42.
Zurück zum Zitat Zheng X, Dai W, Chen X, et al. Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. J Biomed Sci. 2015;22:105.PubMedPubMedCentralCrossRef Zheng X, Dai W, Chen X, et al. Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. J Biomed Sci. 2015;22:105.PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Moco S, Martin FP, Rezzi S. Metabolomics view on gut microbiome modulation by polyphenol-rich foods. J Proteome Res. 2012;11:4781–90PubMedCrossRef Moco S, Martin FP, Rezzi S. Metabolomics view on gut microbiome modulation by polyphenol-rich foods. J Proteome Res. 2012;11:4781–90PubMedCrossRef
44.
Zurück zum Zitat Vaughan MJ, Mitchell T, McSpadden, et al. What's inside that seed we brew? A new approach to mining the coffee microbiome. Appl Environ Microbiol. 2015;81:6518–27.PubMedPubMedCentralCrossRef Vaughan MJ, Mitchell T, McSpadden, et al. What's inside that seed we brew? A new approach to mining the coffee microbiome. Appl Environ Microbiol. 2015;81:6518–27.PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Nishitsuji K, Watanabe S, Xiao J, et al Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome. Sci Rep. 2018;8:16173.PubMedPubMedCentralCrossRef Nishitsuji K, Watanabe S, Xiao J, et al Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome. Sci Rep. 2018;8:16173.PubMedPubMedCentralCrossRef
46.
Zurück zum Zitat Zhou L, Foster JA. Psychobiotics and the gut-brain axis: in the pursuit of happiness. Neuropsychiatr Dis Treat. 2015;11:715–23.PubMedPubMedCentral Zhou L, Foster JA. Psychobiotics and the gut-brain axis: in the pursuit of happiness. Neuropsychiatr Dis Treat. 2015;11:715–23.PubMedPubMedCentral
47.
Zurück zum Zitat Tang J, Zheng JS, Fang L, et al. Tea consumption and mortality of all cancers, CVD and all causes: a meta-analysis of eighteen prospective cohort studies. Br J Nutr. 2015;114:673–83.PubMedCrossRef Tang J, Zheng JS, Fang L, et al. Tea consumption and mortality of all cancers, CVD and all causes: a meta-analysis of eighteen prospective cohort studies. Br J Nutr. 2015;114:673–83.PubMedCrossRef
48.
Zurück zum Zitat Zhang C, Qin YY, Wei X, et al. Tea consumption and risk of cardiovascular outcomes and total mortality: a systematic review and meta-analysis of prospective observational studies. Eur J Epidemiol. 2015;30:103–13.PubMedCrossRef Zhang C, Qin YY, Wei X, et al. Tea consumption and risk of cardiovascular outcomes and total mortality: a systematic review and meta-analysis of prospective observational studies. Eur J Epidemiol. 2015;30:103–13.PubMedCrossRef
49.
Zurück zum Zitat Fon Sing M, Yang WS, Gao S, et al. Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. Eur J Cancer Prev. 2011;20:157–65.PubMedCrossRef Fon Sing M, Yang WS, Gao S, et al. Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. Eur J Cancer Prev. 2011;20:157–65.PubMedCrossRef
50.
Zurück zum Zitat Mansour-Ghanaei F, Hadi A, Pourmasoumi M, et al. Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta-analysis of clinical trials. Phytother Res. 2018;32:1876–84.PubMedCrossRef Mansour-Ghanaei F, Hadi A, Pourmasoumi M, et al. Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta-analysis of clinical trials. Phytother Res. 2018;32:1876–84.PubMedCrossRef
51.
Zurück zum Zitat Jin X, Zheng RH, Li YM. Green tea consumption and liver disease: a systematic review. Liver Int. 2008;28:990–6.PubMedCrossRef Jin X, Zheng RH, Li YM. Green tea consumption and liver disease: a systematic review. Liver Int. 2008;28:990–6.PubMedCrossRef
52.
Zurück zum Zitat Hu J, Webster D, Cao J, et al. The safety of green tea and green tea extract consumption in adults - Results of a systematic review. Regul Toxicol Pharmacol. 2018;95:412–33.PubMedCrossRef Hu J, Webster D, Cao J, et al. The safety of green tea and green tea extract consumption in adults - Results of a systematic review. Regul Toxicol Pharmacol. 2018;95:412–33.PubMedCrossRef
53.
Zurück zum Zitat Wijarnpreecha K, Thongprayoon C, Edmonds PJ, et al. Associations of sugar- and artificially sweetened soda with nonalcoholic fatty liver disease: a systematic review and meta-analysis. QJM. 2016;109:461–6.PubMedCrossRef Wijarnpreecha K, Thongprayoon C, Edmonds PJ, et al. Associations of sugar- and artificially sweetened soda with nonalcoholic fatty liver disease: a systematic review and meta-analysis. QJM. 2016;109:461–6.PubMedCrossRef
55.
Zurück zum Zitat Chung M, Ma J, Patel K, et al. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. Am J Clin Nutr. 2014;100:833–49.PubMedPubMedCentralCrossRef Chung M, Ma J, Patel K, et al. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. Am J Clin Nutr. 2014;100:833–49.PubMedPubMedCentralCrossRef
56.
Zurück zum Zitat Chiu S, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr. 2014;68:416–23.PubMedPubMedCentralCrossRef Chiu S, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr. 2014;68:416–23.PubMedPubMedCentralCrossRef
57.
Zurück zum Zitat Riveros MJ, Parada A, Pettinelli P. Fructose consumption and its health implications; fructose malabsorption and nonalcoholic fatty liver disease. Nutr Hosp. 2014;29:491–9.PubMed Riveros MJ, Parada A, Pettinelli P. Fructose consumption and its health implications; fructose malabsorption and nonalcoholic fatty liver disease. Nutr Hosp. 2014;29:491–9.PubMed
58.
Zurück zum Zitat Buitrago-Lopez A, Sanderson J, Johnson L, et al. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ. 2011;343:d4488.PubMedPubMedCentralCrossRef Buitrago-Lopez A, Sanderson J, Johnson L, et al. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ. 2011;343:d4488.PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Hooper L, Kay C, Abdelhamid A, et al. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr. 2012;95:740–51.PubMedCrossRef Hooper L, Kay C, Abdelhamid A, et al. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr. 2012;95:740–51.PubMedCrossRef
60.
Zurück zum Zitat Kerimi A, Williamson G. The cardiovascular benefits of dark chocolate. Vascul Pharmacol. 2015;71:11–5.PubMedCrossRef Kerimi A, Williamson G. The cardiovascular benefits of dark chocolate. Vascul Pharmacol. 2015;71:11–5.PubMedCrossRef
61.
Zurück zum Zitat Kwok CS, Boekholdt SM, Lentjes MA, et al. Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women. Heart. 2015;101:1279–87.PubMedCrossRef Kwok CS, Boekholdt SM, Lentjes MA, et al. Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women. Heart. 2015;101:1279–87.PubMedCrossRef
62.
Zurück zum Zitat Strat KM, Rowley TJ, Smithson AT, et al. Mechanisms by which cocoa flavanols improve metabolic syndrome and related disorders. J Nutr Biochem. 2016;35:1–21.PubMedCrossRef Strat KM, Rowley TJ, Smithson AT, et al. Mechanisms by which cocoa flavanols improve metabolic syndrome and related disorders. J Nutr Biochem. 2016;35:1–21.PubMedCrossRef
63.
Zurück zum Zitat Davison K, Howe PR. Potential implications of dose and diet for the effects of cocoa flavanols on cardiometabolic function. J Agric Food Chem. 2015;63:9942–7.PubMedCrossRef Davison K, Howe PR. Potential implications of dose and diet for the effects of cocoa flavanols on cardiometabolic function. J Agric Food Chem. 2015;63:9942–7.PubMedCrossRef
64.
Zurück zum Zitat Malhi H, Loomba R. Editorial: dark chocolate may improve NAFLD and metabolic syndrome by reducing oxidative stress. Aliment Pharmacol Ther. 2016;44:533–4.PubMedPubMedCentralCrossRef Malhi H, Loomba R. Editorial: dark chocolate may improve NAFLD and metabolic syndrome by reducing oxidative stress. Aliment Pharmacol Ther. 2016;44:533–4.PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Sander R. Benefits of dark chocolate in treating metabolic syndrome. Nurs Older People. 2012;24:11.PubMed Sander R. Benefits of dark chocolate in treating metabolic syndrome. Nurs Older People. 2012;24:11.PubMed
66.
67.
Zurück zum Zitat Loffredo L, Baratta F, Ludovica P, et al. Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis. Nutr Metab Cardiovasc Dis. 2018;28:143–9.CrossRef Loffredo L, Baratta F, Ludovica P, et al. Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis. Nutr Metab Cardiovasc Dis. 2018;28:143–9.CrossRef
68.
Zurück zum Zitat Noad RL, Rooney C, McCall D, et al. Beneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomised control trial. Heart. 2016;102:1371–9.PubMedCrossRef Noad RL, Rooney C, McCall D, et al. Beneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomised control trial. Heart. 2016;102:1371–9.PubMedCrossRef
69.
Zurück zum Zitat Leyva-Soto A, Chavez-Santoscoy RA, Lara-Jacobo LR, et al. Daily consumption of chocolate rich in flavonoids decreases cellular genotoxicity and improves biochemical parameters of lipid and glucose metabolism. Molecules. 2018;23. pii: E2220.PubMed Leyva-Soto A, Chavez-Santoscoy RA, Lara-Jacobo LR, et al. Daily consumption of chocolate rich in flavonoids decreases cellular genotoxicity and improves biochemical parameters of lipid and glucose metabolism. Molecules. 2018;23. pii: E2220.PubMed
70.
Zurück zum Zitat Shah SR, Alweis R, Najim NI, et al. Use of dark chocolate for diabetic patients: a review of the literature and current evidence. J Community Hosp Intern Med Perspect. 2017;7:218–21.PubMedPubMedCentralCrossRef Shah SR, Alweis R, Najim NI, et al. Use of dark chocolate for diabetic patients: a review of the literature and current evidence. J Community Hosp Intern Med Perspect. 2017;7:218–21.PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Carrieri MP, Lions C, Sogni P, et al. Association between elevated coffee consumption and daily chocolate intake with normal liver enzymes in HIV-HCV infected individuals: results from the ANRS CO13 HEPAVIH cohort study. J Hepatol. 2014;60:46–53.PubMedCrossRef Carrieri MP, Lions C, Sogni P, et al. Association between elevated coffee consumption and daily chocolate intake with normal liver enzymes in HIV-HCV infected individuals: results from the ANRS CO13 HEPAVIH cohort study. J Hepatol. 2014;60:46–53.PubMedCrossRef
72.
Zurück zum Zitat Alkerwi A, Sauvageot N, Crichton GE, et al. Daily chocolate consumption is inversely associated with insulin resistance and liver enzymes in the Observation of Cardiovascular Risk Factors in Luxembourg study. Br J Nutr. 2016;115:1661–8.PubMedCrossRef Alkerwi A, Sauvageot N, Crichton GE, et al. Daily chocolate consumption is inversely associated with insulin resistance and liver enzymes in the Observation of Cardiovascular Risk Factors in Luxembourg study. Br J Nutr. 2016;115:1661–8.PubMedCrossRef
73.
Zurück zum Zitat Lee Y, Berryman CE, West SG, et al. Effects of dark chocolate and almonds on cardiovascular risk factors in overweight and obese individuals: a randomized controlled-feeding trial. J Am Heart Assoc. 2017;6 (12). pii:e005162.PubMedPubMedCentral Lee Y, Berryman CE, West SG, et al. Effects of dark chocolate and almonds on cardiovascular risk factors in overweight and obese individuals: a randomized controlled-feeding trial. J Am Heart Assoc. 2017;6 (12). pii:e005162.PubMedPubMedCentral
74.
Zurück zum Zitat Tokede OA, Gaziano JM, Djoussé L. Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. Eur J Clin Nutr. 2011;65:879–86.PubMedCrossRef Tokede OA, Gaziano JM, Djoussé L. Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. Eur J Clin Nutr. 2011;65:879–86.PubMedCrossRef
75.
Zurück zum Zitat Martin FP, Rezzi S, Peré-Trepat E, et al. Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. J Proteome Res. 2009;8:5568–79.PubMedCrossRef Martin FP, Rezzi S, Peré-Trepat E, et al. Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. J Proteome Res. 2009;8:5568–79.PubMedCrossRef
76.
Zurück zum Zitat Petyaev IM, Bashmakov YK. Cocobiota: Implications for Human Health. J Nutr Meta. 2016;2016:7906927. Petyaev IM, Bashmakov YK. Cocobiota: Implications for Human Health. J Nutr Meta. 2016;2016:7906927.
77.
Zurück zum Zitat Lv J, Qi L, Yu C, Yang L, et al. China Kadoorie Biobank Collaborative Group. Consumption of spicy foods and total and cause specific mortality: population based cohort study. BMJ. 2015;351:h3942.PubMedPubMedCentralCrossRef Lv J, Qi L, Yu C, Yang L, et al. China Kadoorie Biobank Collaborative Group. Consumption of spicy foods and total and cause specific mortality: population based cohort study. BMJ. 2015;351:h3942.PubMedPubMedCentralCrossRef
78.
Zurück zum Zitat Yuan LJ, Qin Y, Wang L, et al. Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns. Clin Nutr. 2016;35:388–93.PubMedCrossRef Yuan LJ, Qin Y, Wang L, et al. Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns. Clin Nutr. 2016;35:388–93.PubMedCrossRef
79.
Zurück zum Zitat Sun F, Xiong S, Zhu Z. Dietary capsaicin protects cardiometabolic organs from dysfunction. Nutrients. 2016;8. Sun F, Xiong S, Zhu Z. Dietary capsaicin protects cardiometabolic organs from dysfunction. Nutrients. 2016;8.
80.
Zurück zum Zitat Chopan M, Littenberg B. The association of hot red chili pepper consumption and mortality: a large population-based cohort study. PLoS One. 2017;12:e0169876.PubMedPubMedCentralCrossRef Chopan M, Littenberg B. The association of hot red chili pepper consumption and mortality: a large population-based cohort study. PLoS One. 2017;12:e0169876.PubMedPubMedCentralCrossRef
81.
Zurück zum Zitat Sanati S, Razavi BM, Hosseinzadeh H. A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome. Iran J Basic Med Sci. 2018;21:439–48.PubMedPubMedCentral Sanati S, Razavi BM, Hosseinzadeh H. A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome. Iran J Basic Med Sci. 2018;21:439–48.PubMedPubMedCentral
82.
Zurück zum Zitat Aune D, Keum N, Giovannucci E. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. BMC Med. 2016;14:207.PubMedPubMedCentralCrossRef Aune D, Keum N, Giovannucci E. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. BMC Med. 2016;14:207.PubMedPubMedCentralCrossRef
83.
Zurück zum Zitat Chen GC, Zhang R, Martínez-González MA, et al. Nut consumption in relation to all-cause and cause-specific mortality: a meta-analysis 18 prospective studies. Food Funct. 2017;8:3893–905.PubMedCrossRef Chen GC, Zhang R, Martínez-González MA, et al. Nut consumption in relation to all-cause and cause-specific mortality: a meta-analysis 18 prospective studies. Food Funct. 2017;8:3893–905.PubMedCrossRef
84.
Zurück zum Zitat Tuccinardi D, Farr OM, Upadhyay J, et al. Mechanisms Underlying the Cardiometabolic Protective Effect of Walnut Consumption in Obese Subjects: A Cross-Over, Randomized, Double-Blinded, Controlled Inpatient Physiology Study. Diabetes Obes Metab. 2019 May 14. Tuccinardi D, Farr OM, Upadhyay J, et al. Mechanisms Underlying the Cardiometabolic Protective Effect of Walnut Consumption in Obese Subjects: A Cross-Over, Randomized, Double-Blinded, Controlled Inpatient Physiology Study. Diabetes Obes Metab. 2019 May 14.
85.
Zurück zum Zitat Kim Y, Keogh J, Clifton PM. Nuts and Cardio-Metabolic Disease: A Review of Meta-Analyses. Nutrients. 2018;10. pii: E1935.PubMedCrossRef Kim Y, Keogh J, Clifton PM. Nuts and Cardio-Metabolic Disease: A Review of Meta-Analyses. Nutrients. 2018;10. pii: E1935.PubMedCrossRef
86.
Zurück zum Zitat Eslami O, Shidfar F, Dehnad A. Inverse association of long-term nut consumption with weight gain and risk of overweight/obesity: a systematic review. Nutr Res. 2019 Apr 11;68:1–8.PubMedCrossRef Eslami O, Shidfar F, Dehnad A. Inverse association of long-term nut consumption with weight gain and risk of overweight/obesity: a systematic review. Nutr Res. 2019 Apr 11;68:1–8.PubMedCrossRef
88.
Zurück zum Zitat Dunn W, Sanyal AJ, Brunt EM, et al. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD). J Hepatol. 2012;57:384–91.PubMedPubMedCentralCrossRef Dunn W, Sanyal AJ, Brunt EM, et al. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD). J Hepatol. 2012;57:384–91.PubMedPubMedCentralCrossRef
89.
Zurück zum Zitat Sookoian S, Castaño GO, Pirola CJ. Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals. Gut. 2014;63:530–2.PubMedCrossRef Sookoian S, Castaño GO, Pirola CJ. Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals. Gut. 2014;63:530–2.PubMedCrossRef
90.
Zurück zum Zitat GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392:1015–35.PubMedCentralCrossRef GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392:1015–35.PubMedCentralCrossRef
92.
Zurück zum Zitat Ajmera VH, Terrault NA, Harrison SA. Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review. Hepatology. 2017;65:2090–9.PubMedCrossRef Ajmera VH, Terrault NA, Harrison SA. Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review. Hepatology. 2017;65:2090–9.PubMedCrossRef
93.
Zurück zum Zitat Liu Y, Dai M, Bi Y, et al. Active smoking, passive smoking, and risk of nonalcoholic fatty liver disease (NAFLD): a population-based study in China. J Epidemiol. 2013;23:115–21.PubMedPubMedCentralCrossRef Liu Y, Dai M, Bi Y, et al. Active smoking, passive smoking, and risk of nonalcoholic fatty liver disease (NAFLD): a population-based study in China. J Epidemiol. 2013;23:115–21.PubMedPubMedCentralCrossRef
94.
Zurück zum Zitat Hamabe A, Uto H, Imamura Y, et al. Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period. J Gastroenterol. 2011;46:769–78.PubMedCrossRef Hamabe A, Uto H, Imamura Y, et al. Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period. J Gastroenterol. 2011;46:769–78.PubMedCrossRef
95.
Zurück zum Zitat Rezayat AA, Moghadam DM, Nour GM, et al. Association between smoking and non-alcoholic fatty liver disease: A systematic review and meta-analysis. SAGE Open Med. 2018;6:2050312117745223. Rezayat AA, Moghadam DM, Nour GM, et al. Association between smoking and non-alcoholic fatty liver disease: A systematic review and meta-analysis. SAGE Open Med. 2018;6:2050312117745223.
96.
Zurück zum Zitat Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. Connection of nicotine to diet-induced obesity and non-alcoholic fatty liver disease: cellular and mechanistic insights. Front Endocrinol (Lausanne). 2017 Feb 10;8:23.CrossRef Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. Connection of nicotine to diet-induced obesity and non-alcoholic fatty liver disease: cellular and mechanistic insights. Front Endocrinol (Lausanne). 2017 Feb 10;8:23.CrossRef
97.
Zurück zum Zitat Andreu V, Mas A, Bruguera M, et al. Ecstasy: a common cause of severe acute hepatotoxicity. J Hepatol. 1998;29:394–7.PubMedCrossRef Andreu V, Mas A, Bruguera M, et al. Ecstasy: a common cause of severe acute hepatotoxicity. J Hepatol. 1998;29:394–7.PubMedCrossRef
98.
Zurück zum Zitat Jones AL, Simpson KJ. Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications. Aliment Pharmacol. 1999;13:129–33.CrossRef Jones AL, Simpson KJ. Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications. Aliment Pharmacol. 1999;13:129–33.CrossRef
99.
Zurück zum Zitat Tarantino G, Citro V, Finelli C. Recreational drugs: a new health hazard for patients with concomitant chronic liver diseases. J Gastrointest Liver Dis. 2014;23:79–84. Tarantino G, Citro V, Finelli C. Recreational drugs: a new health hazard for patients with concomitant chronic liver diseases. J Gastrointest Liver Dis. 2014;23:79–84.
100.
Zurück zum Zitat Roy DN, Goswami R. Drugs of abuse and addiction: A slippery slope toward liver injury. Chem Biol Interact. 2016;255:92–105.PubMedCrossRef Roy DN, Goswami R. Drugs of abuse and addiction: A slippery slope toward liver injury. Chem Biol Interact. 2016;255:92–105.PubMedCrossRef
101.
Zurück zum Zitat Deveaux V, Cadoudal T, Ichigotani Y, et al. Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS One. 2009;4:e5844.PubMedPubMedCentralCrossRef Deveaux V, Cadoudal T, Ichigotani Y, et al. Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS One. 2009;4:e5844.PubMedPubMedCentralCrossRef
102.
Zurück zum Zitat Hézode C, Zafrani ES, Roudot-Horaval F, et al. Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C. Gastroenterology. 2008;134:432–9.PubMedCrossRef Hézode C, Zafrani ES, Roudot-Horaval F, et al. Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C. Gastroenterology. 2008;134:432–9.PubMedCrossRef
103.
Zurück zum Zitat Dibba P, Li A, Cholankeril G, et al. Mechanistic potential and therapeutic implications of cannabinoids in nonalcoholic fatty liver disease. Medicines (Basel). 2018a;5 (2). pii:E47.CrossRef Dibba P, Li A, Cholankeril G, et al. Mechanistic potential and therapeutic implications of cannabinoids in nonalcoholic fatty liver disease. Medicines (Basel). 2018a;5 (2). pii:E47.CrossRef
104.
Zurück zum Zitat Dibba P, Li AA, Cholankeril G, et al. The role of cannabinoids in the setting of cirrhosis. Medicines (Basel). 2018b;5 (2). pii:E52CrossRef Dibba P, Li AA, Cholankeril G, et al. The role of cannabinoids in the setting of cirrhosis. Medicines (Basel). 2018b;5 (2). pii:E52CrossRef
Metadaten
Titel
Hepatologie — Teil 5 : Ernährung und NAFLD
Welchen Einfluss haben Ernährung und Genussmittel auf die Fettleber?
verfasst von
Prof. Dr. med. Claus Niederau
Publikationsdatum
13.09.2019
Verlag
Springer Medizin
Erschienen in
Gastro-News / Ausgabe 5/2019
Print ISSN: 1869-1005
Elektronische ISSN: 2520-8667
DOI
https://doi.org/10.1007/s15036-019-0660-y

Weitere Artikel der Ausgabe 5/2019

Gastro-News 5/2019 Zur Ausgabe

Passend zum Thema

ANZEIGE

Fatal verkannt: Vitamin-B12-Mangel frühzeitig behandeln!

Müdigkeit und Erschöpfung sind meist die ersten Symptome eines Vitamin-B12-Mangels. Wird das Defizit nicht rechtzeitig behandelt, drohen mitunter schwerwiegende Folgen. Lesen Sie hier, was bei der Therapie zu beachten ist.

ANZEIGE

Vitamin-B12-Mangel durch Arzneimittel

Einige häufig verordnete Medikamente wie das orale Antidiabetikum Metformin oder Protonenpumpeninhibitoren (PPI) können einen Mangel an Vitamin B12 verursachen. Bei einer Langzeitmedikation mit diesen Wirkstoffen sollte daher an ein mögliches Defizit gedacht werden. Erfahren Sie hier, worauf dabei zu achten ist.

ANZEIGE

Vitamin-B12-Mangel – Aktuelles Basiswissen für die Praxis.

Content Hub

Ein Mangel an Vitamin B12 tritt in bestimmten Risikogruppen häufig auf. Diese Patienten sind auch regelmäßig in Ihrer Praxis. Wird der Mangel nicht rechtzeitig behandelt, drohen mitunter schwerwiegende Folgen. Erhalten Sie hier einen Überblick über aktuelles Basiswissen für den Praxisalltag.

WÖRWAG Pharma GmbH & Co. KG