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01.12.2007

Fibroblast growth factor-2 and cardioprotection

verfasst von: Elissavet Kardami, Karen Detillieux, Xin Ma, Zhisheng Jiang, Jon-Jon Santiago, Sarah K. Jimenez, Peter A. Cattini

Erschienen in: Heart Failure Reviews | Ausgabe 3-4/2007

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Abstract

Boosting myocardial resistance to acute as well as chronic ischemic damage would ameliorate the detrimental effects of numerous cardiac pathologies and reduce the probability of transition to heart failure. Experimental cardiology has pointed to ischemic and pharmacological pre- as well as post-conditioning as potent acute cardioprotective manipulations. Additional exciting experimental strategies include the induction of true regenerative and/or angiogenic responses to the damaged heart, resulting in sustained structural and functional beneficial effects. Fibroblast growth factor-2 (FGF-2), an endogenous multifunctional protein with strong affinity for the extracellular matrix and basal lamina and well-documented paracrine, autocrine and intacellular modes of action, has been shown over the years to exert acute and direct pro-survival effects, irrespectively of whether it is administered before, during or after an ischemic insult to the heart. FGF-2 is also a potent angiogenic protein and a crucial agent for the proliferation, expansion, and survival of several cell types including those with stem cell properties. Human clinical trials have pointed to a good safety record for this protein. In this review, we will present a case for the low molecular weight isoform of fibroblast growth factor-2 (lo-FGF-2) as a very promising therapeutic agent to achieve powerful acute as well as sustained benefits for the heart, due to its cytoprotective and regenerative properties.

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Titel: Fibroblast growth factor-2 and cardioprotection
verfasst von: Elissavet Kardami
Karen Detillieux
Xin Ma
Zhisheng Jiang
Jon-Jon Santiago
Sarah K. Jimenez
Peter A. Cattini
Publikationsdatum: 01.12.2007
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Heart Failure Reviews / Ausgabe 3-4/2007
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-007-9027-0

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