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01.08.2014 | Clinical and Epidemiological Study

First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak

verfasst von: T. Vilibic-Cavlek, B. Kaic, L. Barbic, I. Pem-Novosel, V. Slavic-Vrzic, V. Lesnikar, S. Kurecic-Filipovic, A. Babic-Erceg, E. Listes, V. Stevanovic, I. Gjenero-Margan, G. Savini

Erschienen in: Infection | Ausgabe 4/2014

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Abstract

Purpose

We report on first evidence of simultaneous occurrence of West Nile virus (WNV) and Usutu virus (USUV) neuroinvasive infection in humans in Croatia during the transmission season 2013.

Methods

From June to December 2013, a total of 95 patients with clinically suspected WNV infection (WNV fever and neuroinvasive disease) were tested for WNV IgM/IgG antibodies using enzyme-linked immunosorbent assay. Twenty-six reactive samples were further tested by virus neutralization test for confirmation.

Results

WNV neuroinvasive infection was confirmed in 20 patients, while in three patients USUV neutralizing antibodies were detected. Cases occurred during the 11-week interval (from 24 July to 07 October 2013). Both WNV and USUV cases were distributed in three north-western Croatian counties. In addition to human cases, recent asymptomatic WNV infection (detection of IgM antibodies) was recorded in 9/3,460 (0.3 %) tested sentinel horses. Infected animals were recorded in two eastern and one north-western county.

Conclusions

Our results indicate co-circulation of WNV and USUV in Croatia. WNV infection could be misdiagnosed with other emerging infectious diseases presenting with neurological symptoms such as USUV infection.

Lindenbach BD, Thiel HJ, Rice CM. Flaviviridae: the viruses and their replication. In: Knipe DM, Howley PM, editors. Fields virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 1101–51.

Marra PP, Griffing S, Cafreey CL, Kilpatrick AM, McLean R, Brand C, Saito E, Dupuis AP, Kramer L, Novak R. West Nile virus and wildlife. Bioscience. 2004;54:393–402.CrossRef

Hayes EB, Sejvar JJ, Zaki SR, Lanciotti RS, Bode AV, Campbell GL. Virology, pathology, and clinical manifestations of West Nile virus disease. Emerg Infect Dis. 2005;11:1174–9.PubMedCentralPubMedCrossRef

Gaibani P, Pierro AM, Cavrini F, Rossini G, Landini MP, Sambri V. False positive transcription-mediated amplification assay detection of West Nile virus in blood from a patient with viremia caused by an Usutu virus infection. J Clin Microbiol. 2010;48:3338–9.PubMedCentralPubMedCrossRef

Nikolay B, Diallo M, Boye CSB, Sal AA. Usutu virus in Africa. Vector Borne Zoonotic Dis. 2011;11:1417–23.PubMedCrossRef

Pecorari M, Longo G, Gennari W, Grottola A, Sabbatini A, Tagliazucchi S, Savini G, Monaco F, Simone M, Lelli R, Rumpianesi F. First human case of Usutu virus neuroinvasive infection, Italy, August–September 2009. Euro Surveill. 2009;14:pii:19446.

Cavrini F, Gaibani P, Longo G, Pierro AM, Rossini G, Bonilauri P, Gerunda GE, Di Benedetto F, Pasetto A, Girardis M, Dottori M, Landini MP, Sambri V. Usutu virus infection in a patient who underwent orthotropic liver transplantation, Italy, August–September 2009. Euro Surveill. 2009;14:pii:19448.

Calistri P, Giovannini A, Hubalek Z, Ionescu A, Monaco F, Savini G, Lelli R. Epidemiology of West Nile in Europe and in the Mediterranean Basin. Open Virol J. 2010;4:29–37.PubMedCentralPubMed

www. http://ecdc.europa.eu/en/healthtopics/west_nile_fever/West-Nile-fever maps/Pages/index.aspx.

10.

Pradier S, Lecollinet S, Leblond A. West Nile virus epidemiology and factors triggering change in its distribution in Europe. Rev Sci Tech. 2012;31:829–44.PubMed

11.

Pem-Novosel I, Vilibic-Cavlek T, Gjenero-Margan I, Pandak N, Peric L, Barbic L, Listes E, Cvitkovic A, Stevanovic V, Savini G. First outbreak of West Nile virus neuroinvasive disease in humans, Croatia, 2012. Vector Borne Zoonotic Dis. 2014;14:82–4.PubMedCrossRef

12.

Weissenböck H, Kolodziejek J, Url A, Lussy H, Rebel-Bauder B, Nowotny N. Emergence of Usutu virus, an African mosquito borne flavivirus of the Japanese encephalitis virus group, central Europe. Emerg Infect Dis. 2002;8:652–6.PubMedCentralPubMedCrossRef

13.

Bakonyi T, Erdelyi K, Ursu K, Ferenczi E, Csörgo T, Lussy H, Chvala S, Bukovsky C, Meister T, Weissenböck H, Nowotny N. Emergence of Usutu virus in Hungary. J Clin Microbiol. 2007;45:3780–4.CrossRef

14.

Tamba M, Bonilauri P, Bellini R, Calzolari M, Albieri A, Sambri V, Dottori M, Angelini P. Detection of Usutu virus within a West Nile virus surveillance program in Northern Italy. Vector Borne Zoonotic Dis. 2011;11:551–7.PubMedCrossRef

15.

Calzolari M, Gaibani P, Bellin R, Defilippo F, Pierro A, Albieri A, Maioli G, Luppi A, Rossini G, Balzani A, Tamba M, Galletti G, Gelati A, Carrieri M, Poglayen G, Cavrini F, Natalini S, Dottori M, Sambri V, Angelini P, Bonilauri P. Mosquito, bird and human surveillance of West Nile and Usutu viruses in Emilia-Romagna region (Italy) in 2010. PLoS One. 2012;7:e38058.PubMedCentralPubMedCrossRef

16.

Busani L, Capelli G, Cecchinato M, Lorenzetto M, Savini G, Terregino C, Vio P, Bonfanti L, Pozza MD, Marangon S. West Nile virus circulation in Veneto region in 2008–2009. Epidemiol Infect. 2011;139:818–25.PubMedCrossRef

17.

Llorente F, Pérez-Ramírez E, Fernández-Pinero J, Soriguer R, Figuerola J, Jiménez-Clavero MA. Flaviviruses in game birds, southern Spain, 2011-2012. Emerg Infect Dis. 2013;19:1023–5.PubMedCentralPubMedCrossRef

18.

Steinmetz HW, Bakonyi T, Weissenböck H, Hatt JM, Eulenberger U, Robert N, Hoop R, Nowotny N. Emergence and establishment of Usutu virus infection in wild and captive avian species in and around Zurich, Switzerland-genomic and pathologic comparison to other central European outbreaks. Vet Microbiol. 2011;148:207–12.PubMedCrossRef

19.

Becker N, Jöst H, Ziegler U, Eiden M, Höper D, Emmerich P, Fichet-Calvet E, Ehichioya DU, Czajka C, Gabriel M, Hoffmann B, Beer M, Tenner-Racz K, Racz P, Günther S, Wink M, Bosch S, Konrad A, Pfeffer M, Groschup MH, Schmidt-Chanasit J. Epizootic emergence of Usutu virus in wild and captive birds in Germany. PLoS One. 2012;7:e32604.PubMedCentralPubMedCrossRef

20.

Hubálek Z, Rudolf I, Capek M, Bakonyi T, Betášová L, Nowotny N. Usutu Virus in blackbirds (Turdus merula), Czech Republic, 2011–2012. Transbound Emerg Dis. 2012;. doi:10.1111/tbed.12025.PubMed

21.

Savini G, Monaco F, Terregino C, Di Gennaro A, Bano L, Pinoni C, De Nardi R, Bonilauri P, Pecorari M, Di Gialleonardo L, Bonfanti L, Polci A, Calistri P, Lelli R. Usutu virus in Italy: an emergence or a silent infection. Vet Microbiol. 2011;151:264–74.PubMedCrossRef

22.

Gaibani P, Pierro A, Alicino R, Rossini G, Cavrini F, Landini MP, Sambri V. Detection of Usutu-virus-specific IgG in blood donors from Northern Italy. Vector Borne Zoonotic Dis. 2012;12:431–3.PubMedCrossRef

23.

Allering L, Jöst H, Emmerich P, Günther S, Lattwein E, Schmidt M, Seifried E, Sambri V, Hourfar K, Schmidt-Chanasit J. Detection of Usutu virus infection in a healthy blood donor from south-west Germany, 2012. Euro Surveill. 2012;17:pii:20341.

24.

Weissenböck H, Bakonyi T, Rossi G, Mani P, Nowotny N. Usutu virus, Italy, 1996. Emerg Infect Dis. 2013;19:274–7.PubMedCentralPubMedCrossRef

25.

Vazquez A, Jimenez-Clavero M, Franco L, Donoso-Mantke O, Sambri V, Niedrig M, Zeller H, Tenorio A. Usutu virus: potential risk of human disease in Europe. Euro Surveill. 2011;16:pii:19935.

26.

European centre for disease control and prevention. Meeting report. expert consultation on West Nile virus infection. Stockholm, 21–22 April, 2009. Available at: http://ecdc.europa.eu/en/publications/Publications/0909_MER_Expert_consultation_on_WNV.pdf.

27.

Vesenjak-Hirjan J, Galinovic-Weisglass M, Brudnjak Z, Calisher CH, Tovornik D, Lazuick JS, Rendic Z. Island of brac-focus of arbovirus infections. In: Vesenjak-Hirjan J, editor. Arboviruses in the Mediterranean countries. ZbL Bakt. Suppl 9 ed. Stuttgart and New York: Gustav Fischer Verlag; 1980. p. 311–7.

28.

Golubić D, Dobler G. Flaviviruses in the north-west Croatia. Croat J Infect. 2012;32:153–7 (Article in Croatian).

29.

Madić J, Savini G, Di Gennaro A, Monaco F, Jukić B, Kovač S, Rudan N, Listes E. Serological evidence for West Nile virus infection in horses in Croatia. Vet Rec. 2007;160:772–3.PubMedCrossRef

30.

Barbić L, Listeš E, Katić S, Stevanović V, Madić J, Starešina V, Labrović A, Di Gennaro A, Savini G. Spreading of West Nile virus infection in Croatia. Vet Microbiol. 2012;159:504–8.PubMedCrossRef

31.

Cavrini F, Della Pepa ME, Gaibani P, Pierro AM, Rossini G, Landini MP, Sambri V. A rapid and specific real-time RT-PCR assay to identify Usutu virus in human plasma, serum, and cerebrospinal fluid. J Clin Virol. 2011;50:221–3.PubMedCrossRef

32.

Barbic L, Vilibic-Cavlek T, Listes E, Stevanovic V, Gjenero-Margan I, Ljubin-Sternak S, Pem-Novosel I, Listes I, Mlinaric-Galinovic G, Di Gennaro A, Savini G. Demonstration of Usutu virus antibodies in horses, Croatia. Vector Borne Zoonotic Dis. 2013;13:772–4.PubMedCrossRef

33.

Beck C, Jimenez-Clavero MA, Leblond A, Durand B, Nowotny N, Leparc-Goffart I, Zientara S, Jourdain E, Lecollinet S. Flaviviruses in Europe: complex circulation patterns and their consequences for the diagnosis and control of West Nile disease. Int J Environ Res Public Health. 2013;10:6049–83.PubMedCentralPubMedCrossRef

34.

Yeh JY, Lee JH, Park JY, Seo HJ, Moon JS, Cho IS, Kim HP, Yang YJ, Ahn KM, Kyung SG, Choi IS, Lee JB. A diagnostic algorithm to serologically differentiate West Nile virus from Japanese encephalitis virus infections and its validation in field surveillance of poultry and horses. Vector Borne Zoonotic Dis. 2012;12:372–9.PubMedCentralPubMedCrossRef

35.

Stiasny K, Aberle SW, Heinz FX. Retrospective identification of human cases of West Nile virus infection in Austria (2009–2010) by serological differentiation from Usutu and other flavivirus infections. Euro Surveill. 2013;18:pii:20614.

36.

Pierro A, Landini MP, Gaibani P, Rossini G, Vocale C, Finarelli AC, Cagarelli R, Sambri V, Varani S. A model of laboratory surveillance for neuro-arbovirosis applied during 2012 in the Emilia-Romagna region, Italy. Clin Microbiol Infect. 2013;. doi:10.1111/1469-0691.12436.

Titel: First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak
verfasst von: T. Vilibic-Cavlek
B. Kaic
L. Barbic
I. Pem-Novosel
V. Slavic-Vrzic
V. Lesnikar
S. Kurecic-Filipovic
A. Babic-Erceg
E. Listes
V. Stevanovic
I. Gjenero-Margan
G. Savini
Publikationsdatum: 01.08.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Infection / Ausgabe 4/2014
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-014-0625-1

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First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak

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