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Journal of Natural Medicines
Erschienen in:

02.07.2024 | Original Paper

Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities

verfasst von: Kiep Minh Do, Shotaro Hoshino, Takeshi Kodama, Hien Minh Nguyen, Naotaka Ikumi, Hiroyasu Onaka, Hiroyuki Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2024

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Abstract

A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of five new pimarane diterpenes, kaempferiols E–I (1–5). The structures of 1–5 were elucidated by extensive spectroscopic techniques, including HR-ESI–MS, UV, IR, and 1D and 2D NMR. The absolute configurations of 1–3 were determined by the modified Mosher method, and those of 4 and 5 were established by ECD calculations. Further cytotoxic assay for all isolated compounds against three human cancer cell lines, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) indicated that 5 showed moderate cytotoxic activities against the three tested cell lines, with IC50 values of 44.78, 25.97, and 41.39 Mμ for A549, HeLa, and MCF-7 cell lines, respectively.

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Metadaten
Titel
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities
verfasst von
Kiep Minh Do
Shotaro Hoshino
Takeshi Kodama
Hien Minh Nguyen
Naotaka Ikumi
Hiroyasu Onaka
Hiroyuki Morita
Publikationsdatum
02.07.2024
Verlag
Springer Nature Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 4/2024
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-024-01829-8

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