Background
Material and methods
Patient selection
Treatments
Breast surgery
Brachytherapy
Systemic therapy
Follow up
Statistical analysis
Results
Patient and tumor characteristics
Patient features | Number of patients | %/(min – max) |
---|---|---|
Median age (years) | 77.7 | 65.2–92.3 |
Performans Status | ||
0 | 41 | 85.5 |
1 | 7 | 14.5 |
Tumor side | ||
Left | 28 | 54.9 |
Right | 23 | 45.1 |
Median tumor size (mm) | 12 | 3–32 |
Tumor stage | ||
T1a | 28 | 54.9 |
T1b | 18 | 35.3 |
T1c | 5 | 9.8 |
Axillary lymph node status | ||
N0 | 46 | 90.1 |
N1mic | 4 | 7.9 |
N1 | 1 | 2.0 |
Histology type | ||
Invasive ductal carcinoma | 44 | 86.3 |
Invasive lobular carcinoma | 3 | 5.9 |
Other | 4 | 7.8 |
Histological grade | ||
1 | 32 | 62.7 |
2 | 14 | 27.4 |
3 | 5 | 9.8 |
Hormonal status | ||
Positive | 48 | 94.1 |
Negative | 3 | 5.9 |
Her-2 status | ||
Over-expressed | 5 | 9.8 |
Non-over-expressed | 46 | 90.2 |
Peri-neural invasion | ||
Yes | 1 | 1.9 |
No | 50 | 98.1 |
Median Ki-67 (%) Median surg. Marg.(mm) | 10 5 | 5–60 1–10 |
Implant procedure | ||
Intra operative | 47 | 92.2 |
Post-operative | 4 | 7.8 |
Median time interv. Surg./APBI (d) | 7 | 1–63 |
Median number of lines | 11 | 5–15 |
Median number of planes | 2 | 1–3 |
Median CTV (cc) | 44 | 11–124 |
Median V100% (%) | 96 | 86–100 |
Median V150% (%) | 34 | 23–48 |
Median V200% (%) | 12 | 8–21 |
MedianDNR | 0.35 | 0.23–0.56 |
Treatment characteristics
Oncological outcome
Toxicity
Late Toxicity | Number of events | % |
---|---|---|
Grade 1 | ||
Breast fibrosis | 5 | 31.3 |
Puncture site hypopig. | 5 | 31.3 |
Telangectasia | 2 | 12.5 |
Epithelitis | 1 | 6.3 |
Other | 1 | 6.3 |
Total | 14 | 87.5 |
Grade 2 | ||
Breast fibrosis | 2 | 12.5 |
Total number of events | 16 | 100 |
Cosmetic outcome | Number of estimations | % |
Excellent | 39 | 76.4 |
Good | 12 | 25.6 |
Discussion
Authors | Year | # pts | MFU (months) | Irradiation techniques | Total dose (Gy) | D/f (Gy) | AG3 tox (%) | LG3 tox (%) | LF (%) | RF (%) | DM (%) | Ex/goodcosmetic results |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Sacchini | 2008 | 1834 | 31 | HDRIORT | 20/18 | 20/18 | 7.7 | – | 0 | – | – | a |
Khan | 2013 | 30 | 11 | Contura™ | 28 | 7 (BID) | 0 | 0 | – | – | – | – |
Wilkinson | 2012/17 | 45 | 74 | Mammosite™ | 28 | 7 (BID) | 13.3 | 2 | 0 | 0 | 0 | 91 |
Showalter | 2016 | 28 | 6 | HDRIORT | 12.5 | 12.5 | 0 | – | – | – | – | 93 |
Latorre | 2018 | 20 | 24 | HDRMIB | 18 | 18 | 0 | 0 | 0 | 0 | 5 | 80 |
Khan | 2019 | 200 | 12 | HDRMIB/Contura™ | 22,5 | 7,5 | 1.5 | – | 1 | – | – | 97 |
Jethwa | 2019 | 73 | 14 | Balloon | 21 | 7 | 3 | – | – | – | – | – |
SiFEBI | 2018/19 | 26 | 63 | HDRMIB | 16 | 16 | 7.6 | 0 | 0 | 0 | – | 88 |
Study | – | 48 | 39 | HDRMIB | 16 | 16 | 6.3 | 0 | 0 | 2 | 0 | 100 |