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Erschienen in: Clinical and Experimental Nephrology 2/2008

01.04.2008 | Case Report

Focal segmental glomerulosclerosis and nephrotic syndrome in a child with embryonal rhabdomyosarcoma

verfasst von: Wasiu Adekunle Olowu, Abdulkadr Ayo Salako, Kayode Adebowale Adelusola, Oludayo Adedapo Sowande, Victor Adebayo Adetiloye, Olufemi Adefehinti, Stephen Adebayo Osasan

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 2/2008

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Abstract

A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and urethrocystoscopic biopsy specimens, respectively, revealed focal segmental glomerulosclerosis (FSGS) and embryonal RMS. Tumour remission was induced with pulse doses of intravenous vincristine, cyclophosphamide, methotrexate and actinomycin D over a 15-month period. He has been followed-up for 28 months and has maintained a drug-free tumour and proteinuria remission for 1 year. While some malignancies have been reported in association with NS, its occurrence in association with RMS is quite exceptional. We conclude that RMS may be associated with FSGS and NS. Effective treatment of the RMS was associated with sustained remission of the nephrotic proteinuria.
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Metadaten
Titel
Focal segmental glomerulosclerosis and nephrotic syndrome in a child with embryonal rhabdomyosarcoma
verfasst von
Wasiu Adekunle Olowu
Abdulkadr Ayo Salako
Kayode Adebowale Adelusola
Oludayo Adedapo Sowande
Victor Adebayo Adetiloye
Olufemi Adefehinti
Stephen Adebayo Osasan
Publikationsdatum
01.04.2008
Verlag
Springer Japan
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 2/2008
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-007-0015-4

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