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Erschienen in: Current Treatment Options in Cardiovascular Medicine 11/2015

01.11.2015 | Pediatric Congenital Heart Disease (G Singh, Section Editor)

Fontan Liver Disease: Review of an Emerging Epidemic and Management Options

verfasst von: Elisa Bradley, MD, Benjamin Hendrickson, MD, Curt Daniels, MD

Erschienen in: Current Treatment Options in Cardiovascular Medicine | Ausgabe 11/2015

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Opinion statement

Adults with complex congenital heart disease that resulted in a Fontan procedure frequently experience late cardiac failure. Increasingly, liver disease is recognized as an important complication of single-ventricle anatomy and Fontan physiology; however, there is no consensus regarding liver evaluation in this population. Here, we review what is known about liver disease in this unique group and propose screening and prevention measures. We also review controversial treatment areas including assist devices and transplantation, with a review of outcomes in isolated heart and combined heart-liver transplant.
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82.•
Zurück zum Zitat Simpson KE, Esmaeeli A, Khanna G, White F, Turnmelle Y, Eghtesady P, et al. Liver cirrhosis in Fontan patients does not affect 1-year post-heart transplant mortality or markers of liver function. J Heart Lung Transplant. 2014;33:170–7. The only study evaluating liver function post isolated heart transplant in Fontan patients.PubMedCentralCrossRefPubMed Simpson KE, Esmaeeli A, Khanna G, White F, Turnmelle Y, Eghtesady P, et al. Liver cirrhosis in Fontan patients does not affect 1-year post-heart transplant mortality or markers of liver function. J Heart Lung Transplant. 2014;33:170–7. The only study evaluating liver function post isolated heart transplant in Fontan patients.PubMedCentralCrossRefPubMed
83.••
Zurück zum Zitat Farr M, Mitchell J, Lippel M, Kato TS, Jin Z, Ippolito P, et al. Combination of liver biopsy with MELD-XI scores for post-transplant outcome prediction in patients with advanced heart failure and suspected liver dysfunction. J Heart Lung Transplant. 2015;34:873–82. The first and only study proposing a risk score inclusive of pathologic and clinical markers of liver disease in patients who have undergone combined heart liver transplant.CrossRefPubMed Farr M, Mitchell J, Lippel M, Kato TS, Jin Z, Ippolito P, et al. Combination of liver biopsy with MELD-XI scores for post-transplant outcome prediction in patients with advanced heart failure and suspected liver dysfunction. J Heart Lung Transplant. 2015;34:873–82. The first and only study proposing a risk score inclusive of pathologic and clinical markers of liver disease in patients who have undergone combined heart liver transplant.CrossRefPubMed
Metadaten
Titel
Fontan Liver Disease: Review of an Emerging Epidemic and Management Options
verfasst von
Elisa Bradley, MD
Benjamin Hendrickson, MD
Curt Daniels, MD
Publikationsdatum
01.11.2015
Verlag
Springer US
Erschienen in
Current Treatment Options in Cardiovascular Medicine / Ausgabe 11/2015
Print ISSN: 1092-8464
Elektronische ISSN: 1534-3189
DOI
https://doi.org/10.1007/s11936-015-0412-z

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