Background
Methods
Atopic dermatitis
IgE measurement
Food allergy
Atopic comorbidity
Statistical analysis
Results
Patient characteristics
Total n = 211 | Mild/moderate AD n = 141 | Severe AD n = 70 | P-value† | |
---|---|---|---|---|
Female, n (%)
†
| 138 (65.4) | 102 (72.3) | 36 (51.4) | 0.003* |
Age, year
1,2
| 28.0 (22.0-44.0) | 26.0 (21.0-42.0) | 39.0 (26.0-49.0) | < 0.001* |
Total IgE, kU/L
1,2,3
| 1455.0 (372.5-5000) | 694 (171-2099) | 5000 (1884.5-5000) | < 0.001* |
TARC, pg/mL
1,2,4
| 1328.0 (470.0-3908.0) | 743 (336.3-1683.3) | 2826 (1682-7819) | < 0.001* |
SASSAD
1,2,4
| 21.0 (10.0-31.0) | 17.0 (8.0-27.8) | 24.0 (18.0-38.0) | < 0.001* |
Other atopic diseases:
| ||||
Asthma,
5
†
n (%)
| 102 (49.8) | 68 (49.3) | 34 (50.7) | 0.843 |
AR, seasonal, tree/grass,
6
†
n (%)
| 131 (64.9) | 88 (64.2) | 43 (66.2) | 0.789 |
AR, cat/dog,
7
†
n (%)
| 100 (55.2) | 67 (53.6) | 33 (58.9) | 0.505 |
Food sensitization and positive history of food allergy (frequency and severity) in adult patients with atopic dermatitis
Group analysis | Total n = 211 (%) | Mild/moderate AD n = 141 (%) | Severe AD n = 70 (%) |
---|---|---|---|
AD; no FA, no sensitization
| 54 (25.6) | 41 (29.1) | 13 (18.6) |
AD; no FA, only sensitization
| 43 (20.4) | 27 (19.1) | 16 (22.9) |
AD; FA supported by sensitization
| 114 (54.0) | 73 (51.8) | 41 (58.6) |
Sensitization to food allergens of plant origin
Food | Allergen | Total n = 211 | Mild/moderate AD n = 141 | Severe AD n = 70 | P-value n (%)1median
2
| |
---|---|---|---|---|---|---|
Kiwi
| n (%) | 76 (36.0) | 44 (31.2) | 32 (45.7) | 0.04 | |
nAct d 1 | n (%) | 24 (11.4) | 11 (7.8) | 13 (18.6) | 0.02 | |
(cyst. protease)
|
Median (IQR)
|
1.83 (0.49-10.95)
|
2.10 (1.06-11.32)
|
0.71 (0.36-13.39)
|
0.28
| |
nAct d 2 | n (%) | 25 (11.8) | 17 (12.1) | 8 (11.4) | 0.89 | |
(TLP)
|
Median (IQR)
|
1.92 (1.08-3.23)
|
1.92 (1.49-3.44)
|
1.36 (0.82-3.19)
|
0.29
| |
nAct d 5 | n (%) | 1 (0.5) | 0 (0) | 1 (1.4) | n.r. | |
(Kiwellin)
|
Median (IQR)
|
0.62 (0.62-0.62)
|
-
|
0.62 (0.62-0.62)
|
n.r.
| |
nAct d 8 | n (%) | 44 (20.9) | 27 (19.1) | 17 (24.3) | 0.39 | |
(PR-10)
|
Median (IQR)
|
1.93 (0.76-7.17)
|
1.83 (0.74-3.93)
|
2.52 (1.12-10.81)
|
0.16
| |
Peanut
| n (%) | 119 (56.4) | 74 (52.5) | 45 (64.3) | 0.10 | |
nAra h 1 | n (%) | 24 (11.4) | 9 (6.4) | 15 (21.4) | 0.001* | |
(SP)
|
Median (IQR)
|
6.78 (1.45-11.83)
|
7.70 (3.93-17.16)
|
4.62 (0.95-12.09)
|
0.46
| |
nAra h 2 | n (%) | 23 (10.9) | 14 (9.9) | 9 (12.9) | 0.52 | |
(SP)
|
Median (IQR)
|
15.78 (5.55-35.6)
|
11.41 (4.89-33.30)
|
32.69 (8.18-56.05)
|
0.31
| |
nAra h 3 | n (%) | 16 (7.6) | 7 (5.0) | 9 (12.9) | 0.04 | |
(SP)
|
Median (IQR)
|
4.82 (1.0-22.66)
|
1.61 (0.88-42.95)
|
5.60 (1.33-22.26)
|
0.79
| |
rAra h 8 | n (%) | 112 (53.1) | 70 (49.6) | 42 (60.0) | 0.16 | |
(PR-10)
|
Median (IQR)
|
4.73 (1.66-13.02)
|
3.76 (1.57-9.18)
|
8.81 (1.85-16.16)
|
0.08
| |
Hazelnut
| n (%) | 120 (56.9) | 78 (55.3) | 42 (60.0) | 0.52 | |
rCor a 1.0401 | n (%) | 117 (55.5) | 76 (53.9) | 41 (58.6) | 0.52 | |
(PR-10)
|
Median (IQR)
|
5.29 (2.30-12.37)
|
4.76 (2.18-12.0)
|
5.63 (2.38-16.03)
|
0.50
| |
rCor a 8 | n (%) | 11 (5.2) | 7 (5.0) | 4 (5.7) | n.r. | |
(LTP)
|
Median (IQR)
|
2.78 (0.50-5.49)
|
2.94 (0.85-5.49)
|
0.81 (0.37-28.58)
|
0.35
| |
nCor a 9 | n (%) | 12 (5.7) | 9 (6.4) | 3 (4.3) | n.r. | |
(SP)
|
Median (IQR)
|
1.49 (0.69-1.60)
|
1.50 (0.98-1.60)
|
0.60 (0.49-x)
|
0.64
| |
Apple
| rMal d 1 | n (%) | 126 (59.7) | 81 (57.4) | 45 (64.3) | 0.34 |
(PR-10)
|
Median (IQR)
|
12.35 (4.50-36.50)
|
10.00 (3.76-29.2)
|
24.02 (5.35-51.38)
|
0.06
| |
Peach
| n (%) | 122 (57.8) | 81 (57.4) | 41 (58.6) | 0.88 | |
rPru p 1 | n (%) | 121 (57.3) | 80 (56.7) | 41 (58.6) | 0.80 | |
(PR-10)
|
Median (IQR)
|
9.08 (2.73-20.78)
|
6.85 (2.33-13.11)
|
11.00 (4.18-30.61)
|
0.02
| |
nPru p 3 | n (%) | 11 (5.2) | 8 (5.7) | 3 (4.3) | n.r. | |
(LTP)
|
Median (IQR)
|
4.40 (2.02-7.21)
|
4.70 (1.88-6.95)
|
2.70 (2.02-x)
|
> 0.99
| |
Tree PR-10
| n (%) | 137 (64.9) | 91 (64.5) | 46 (65.7) | 0.87 | |
rBet v 1 | n (%) | 136 (64.5) | 90 (63.8) | 46 (65.7) | 0.79 | |
Median (IQR)
|
34.97 (11.29-80.86)
|
32.95 (9.36-57.11)
|
48.5 (17.86-116.25)
|
0.009*
| ||
rAln g 1 | n (%) | 129 (61.1) | 84 (59.6) | 45 (64.3) | 0.51 | |
Median (IQR)
|
13.52 (3.37-31.13)
|
10.25 (3.21-29.70)
|
14.89 (4.42-32.04)
|
0.33
| ||
rCor a 1.0101 | n (%) | 118 (55.9) | 76 (53.9) | 42 (60.0) | 0.40 | |
Median (IQR)
|
7.00 (2.45-20.83)
|
7.35 (3.14-20.57)
|
12.50 (6.09 -22.90)
|
0.13
| ||
Total PR-10
| n (%) | 134 (63.5) | 88 (62.4) | 46 (65.7) | 0.64 |
Food n (%) | Total n = 211 | Mild/moderate AD n = 141 | Severe AD n = 70 | P-value1 |
---|---|---|---|---|
Kiwi
| 37 (17.5) | 25 (17.7) | 12 (17.1) | 0.92 |
Peanut
| 43 (20.4) | 27 (19.1) | 16 (22.9) | 0.53 |
Hazelnut
| 35 (16.6) | 24 (17.0) | 11 (15.7) | 0.81 |
Apple
| 70 (33.2) | 49 (34.8) | 21 (30.0) | 0.49 |
Peach
| 28 (13.3) | 17 (12.1) | 11 (15.7) | 0.46 |
Sensitization to food allergens of animal origin
Food allergen | Total n = 211 | Mild/moderate AD n = 141 | Severe AD n = 70 | P-value n (%)1median
2
| ||
---|---|---|---|---|---|---|
Cow’s milk
| n (%) | 51 (24.2) | 26 (18.4) | 25 (35.7) |
0.006*
| |
nBos d 4 | n (%) | 10 (4.7) | 8 (5.7) | 2 (2.9) | n.r. | |
(α-lactalbu.)
|
Median (IQR)
|
0.54 (0.32-2.63)
|
0.54 (0.31-2.37)
|
1.60 (0.40-x)
|
0.60
| |
nBos d 5 | n (%) | 10 (4.7) | 6 (4.3) | 4 (5.7) | n.r. | |
(β-lactoglob.)
|
Median (IQR)
|
1.44 (0.71-4.21)
|
0.89 (0.47-3.04)
|
2.59 (1.98-11.67)
|
0.06
| |
nBos d 6
| n (%) | 11 (5.2) | 6 (4.3) | 5 (7.1) | n.r. | |
(serum albu.)
|
Median (IQR)
|
1.01 (0.53-4.04)
|
0.81 (0.52-5.58)
|
1.54 (0.59-5.89)
|
0.72
| |
nBos d 8
| n (%) | 25 (11.8) | 14 (9.9) | 11 (15.7) | 0.22 | |
(casein)
|
Median (IQR)
|
2.23 (1.11-5.89)
|
1.73 (0.80-4.75)
|
3.30 (1.27-8.69)
|
0.30
| |
nBos d lactoferrin
| n (%) | 34 (16.1) | 16 (11.3) | 18 (25.7) |
0.008*
| |
(transferrin)
|
Median (IQR)
|
1.42 (0.68-2.45)
|
0.97 (0.50-2.05)
|
1.95 (1.12-2.92)
|
0.05
| |
Hen’s egg
| n (%) | 28 (13.3) | 16 (11.3) | 12 (17.1) | 0.24 | |
nGal d 1 | n (%) | 23 (10.9) | 12 (8.5) | 11 (15.7) | 0.11 | |
(ovomucoid)
|
Median (IQR)
|
1.96 (0.63-5.19)
|
2.84 (1.24-5.36)
|
1.16 (0.46-5.19)
|
0.24
| |
nGal d 2 | n (%) | 10 (4.7) | 4 (2.8) | 6 (8.6) | n.r. | |
(ovalbumin)
|
Median (IQR)
|
1.64 (0.51-3.64)
|
0.71 (0.42-4.69)
|
2.21 (1.05-6.63)
|
0.29
| |
nGal d 3 | n (%) | 6 (2.8) | 3 (2.1) | 3 (4.3) | n.r. | |
(ovotransfer.)
|
Median (IQR)
|
1.08 (0.68-2.68)
|
0.78 (0.69-x)
|
2.04 (0.63-x)
|
0.51
| |
nGal d 5 | n (%) | 4 (1.9) | 0 (0) | 4 (5.7) | n.r. | |
(serum albu.)
|
Median (IQR)
|
0.43 (0.31-094)
| - |
0.43 (0.31-094)
| - | |
Fish
| n (%) | 24 (11.4) | 12 (8.5) | 12 (17.1) | 0.06 | |
rCyp c 1 | n (%) | 23 (10.9) | 12 (8.5) | 11 (15.7) | 0.11 | |
(parvalb.)
|
Median (IQR)
|
2.43 (0.50-15.0)
|
2.00 (0.45-8.80)
|
2.43 (0.50-21.78)
|
0.30
| |
rGad c 1 | n (%) | 13 (6.2) | 5 (3.5) | 8 (11.4) | n.r. | |
(parvalb.)
|
Median (IQR)
|
4.96 (2.47-7.85)
|
5.80 (4.65-7.85)
|
3.71 (0.93-18.72)
|
0.24
| |
Shrimp
| n (%) | 15 (7.1) | 5 (3.5) | 10 (14.3) | n.r. | |
rPen a 1 | n (%) | 8 (3.8) | 2 (1.4) | 6 (8.6) | n.r. | |
(tropomyosin)
|
Median (IQR)
|
10.18 (1.24-33.22)
|
28.44 (18.87-x)
|
3.85 (0.54-37.20)
|
0.18
| |
nPen i 1 | n (%) | 11 (5.2) | 4 (2.8) | 7 (10.0) | n.r. | |
(tropomyosin)
|
Median (IQR)
|
5.33 (1.50-26.0)
|
11.08 (0.91-40.31)
|
5.33 (1.50-26.0)
|
0.85
| |
nPen m 1 | n(%) | 13 (6.2) | 4 (2.8) | 9 (12.9) | n.r. | |
(tropomyosin)
|
Median (IQR)
|
5.14 (0.48-30.46)
|
11.24 (0.39-43.73)
|
5.14 (0.70-23.89)
|
> 0.99
| |
Total
3
| n (%) | 75 (35.5) | 39 (27.7) | 36 (51.4) |
0.001*
|
Allergen | Total | Mild/moderate AD | Severe AD | P-value1 |
---|---|---|---|---|
n = 211 (%) | n = 141 (%) | n = 70 (%) | ||
Cow’s milk | 18 (8.5) | 10 (7.1) | 8 (11.4) | 0.29 |
Hen’s egg | 12 (5.7) | 11 (7.8) | 1 (1.4) | n.r |
Fish | 8 (3.8) | 4 (2.8) | 4 (5.7) | n.r |
Shrimp | 4 (1.9) | 2 (1.4) | 2 (2.9) | n.r. |
Total
2
| 27 (12.8) | 15 (10.6) | 12 (17.1) | 0.18 |