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Erschienen in: Current Allergy and Asthma Reports 11/2018

01.11.2018 | Allergens (RK Bush and S Vieths, Section Editors)

Food Allergies Caused by Allergenic Lipid Transfer Proteins: What Is behind the Geographic Restriction?

verfasst von: M. J. Rial, J. Sastre

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 11/2018

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Abstract

Purpose of Review

To critically examine evidence suggesting that food allergy induced by lipid transfer proteins (LTPs) follows a geographic pattern.

Recent Findings

LTP syndrome remains most common in the Mediterranean basin, with a clear gradient seen in prevalence of LTP sensitization between northern and southern Europe. We hypothesize that high levels of birch pollen seem to protect against LTP allergy, as these higher levels correlate with a lower prevalence of LTP hypersensitivity. Nevertheless, LTP food allergy cases still appear in areas having a high environmental level of birch pollen.

Summary

Food allergy caused by LTP may be related to (1) primary sensitization to a food LTP allergen in the absence of pollinosis, (2) primary sensitization to LTP from a pollen source, and (3) co-sensitization to LTP from pollen and food.
Literatur
1.
Zurück zum Zitat • Lleonart R, Cisteró A, Carreira J, Batista A, Moscoso del Prado J. Food allergy: identification of the major IgE-binding component of peach (Prunus persica). Ann Allergy. 1992;69:128–30. First description of an LTP as major allergen in peach. PubMed • Lleonart R, Cisteró A, Carreira J, Batista A, Moscoso del Prado J. Food allergy: identification of the major IgE-binding component of peach (Prunus persica). Ann Allergy. 1992;69:128–30. First description of an LTP as major allergen in peach. PubMed
2.
Zurück zum Zitat Tordesillas L, Gómez-Casado C, Garrido-Arandia M, Murua-García A, Palacín A, Varela J, et al. Transport of Pru p 3 across gastrointestinal epithelium an essential step towards the induction of food allergy? Clin Exp Allergy. 2013;43:1374–83.CrossRefPubMed Tordesillas L, Gómez-Casado C, Garrido-Arandia M, Murua-García A, Palacín A, Varela J, et al. Transport of Pru p 3 across gastrointestinal epithelium an essential step towards the induction of food allergy? Clin Exp Allergy. 2013;43:1374–83.CrossRefPubMed
3.
Zurück zum Zitat Radauer C, Nandy A, Ferreira F, Goodman RE, Larsen JN, Lidholm J, et al. Update of the WHO/IUIS allergen nomenclature database based on analysis of allergen sequences. Allergy. 2014;69:413–9.CrossRefPubMed Radauer C, Nandy A, Ferreira F, Goodman RE, Larsen JN, Lidholm J, et al. Update of the WHO/IUIS allergen nomenclature database based on analysis of allergen sequences. Allergy. 2014;69:413–9.CrossRefPubMed
4.
Zurück zum Zitat •• Pascal M, Muñoz-Cano R, Reina Z, Palacín A, Vilella R, Picado C, et al. Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy. 2012;42:1529–39. Description of LTP syndrome in Mediterranean area. CrossRefPubMed •• Pascal M, Muñoz-Cano R, Reina Z, Palacín A, Vilella R, Picado C, et al. Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy. 2012;42:1529–39. Description of LTP syndrome in Mediterranean area. CrossRefPubMed
5.
Zurück zum Zitat •• Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, et al. EAACI molecular allergology user’s guide. Pediatr Allergy Immunol. 2016;27:1–250. A compendium of molecular diagnosis. CrossRefPubMed •• Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, et al. EAACI molecular allergology user’s guide. Pediatr Allergy Immunol. 2016;27:1–250. A compendium of molecular diagnosis. CrossRefPubMed
6.
Zurück zum Zitat Flores E, Cervera L, Sanz ML, Diaz-Perales A, Fernández J. Plant food allergy in patients with pollinosis from the Mediterranean area. Int Arch Allergy Immunol. 2012;159:346–54.CrossRefPubMed Flores E, Cervera L, Sanz ML, Diaz-Perales A, Fernández J. Plant food allergy in patients with pollinosis from the Mediterranean area. Int Arch Allergy Immunol. 2012;159:346–54.CrossRefPubMed
7.
Zurück zum Zitat Mothes-Luksch N, Raith M, Stingl G, Focke-Tejkl M, Razzazi-Fazeli E, Zieglmayer R, et al. Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe. Allergy. 2017;72:1415–8.CrossRefPubMedPubMedCentral Mothes-Luksch N, Raith M, Stingl G, Focke-Tejkl M, Razzazi-Fazeli E, Zieglmayer R, et al. Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe. Allergy. 2017;72:1415–8.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat •• Vereda A, van Hage M, Ahlstedt S, Ibañez MD, Cuesta-Herranz J, van Odijk J, et al. Peanut allergy: clinical and immunologic differences among patients from 3 different geographic regions. J Allergy Clin Immunol. 2011;127:603–7. An article which compare different pattern of sensitization to peanut in different populations. CrossRefPubMed •• Vereda A, van Hage M, Ahlstedt S, Ibañez MD, Cuesta-Herranz J, van Odijk J, et al. Peanut allergy: clinical and immunologic differences among patients from 3 different geographic regions. J Allergy Clin Immunol. 2011;127:603–7. An article which compare different pattern of sensitization to peanut in different populations. CrossRefPubMed
9.
Zurück zum Zitat Kleine-Tebbe J, Vogel L, Crowell DN, Haustein UF, Vieths S. Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1- related PR-10 protein in soybean, SAM22. J Allergy Clin Immunol. 2002;110:797–804.CrossRefPubMed Kleine-Tebbe J, Vogel L, Crowell DN, Haustein UF, Vieths S. Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1- related PR-10 protein in soybean, SAM22. J Allergy Clin Immunol. 2002;110:797–804.CrossRefPubMed
10.
Zurück zum Zitat Ballmer-Weber BK, Vieths S, Lüttkopf D, Heuschmann P, Wüthrich B. Celery allergy confirmed by double-blind, placebo-controlled food challenge: a clinical study in 32 subjects with a history of adverse reactions to celery root. J Allergy Clin Immunol. 2000;106:373–8.CrossRefPubMed Ballmer-Weber BK, Vieths S, Lüttkopf D, Heuschmann P, Wüthrich B. Celery allergy confirmed by double-blind, placebo-controlled food challenge: a clinical study in 32 subjects with a history of adverse reactions to celery root. J Allergy Clin Immunol. 2000;106:373–8.CrossRefPubMed
11.
Zurück zum Zitat Palacín A, Tordesillas L, Gamboa P, Sanchez-Monge R, Cuesta-Herranz J, Sanz ML. Characterization of peach thaumatin-like proteins and their identification as major peach allergens. Clin Exp Allergy. 2010;40:1422–30.CrossRefPubMed Palacín A, Tordesillas L, Gamboa P, Sanchez-Monge R, Cuesta-Herranz J, Sanz ML. Characterization of peach thaumatin-like proteins and their identification as major peach allergens. Clin Exp Allergy. 2010;40:1422–30.CrossRefPubMed
12.
Zurück zum Zitat Ballmer-Weber BK, Lidholm J, Fernández-Rivas M, Seneviratne S, Hanschmann KM, Vogel L, et al. IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study. Allergy. 2015;70:391–407.CrossRefPubMed Ballmer-Weber BK, Lidholm J, Fernández-Rivas M, Seneviratne S, Hanschmann KM, Vogel L, et al. IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study. Allergy. 2015;70:391–407.CrossRefPubMed
13.
Zurück zum Zitat Azofra J, Berroa F, Gastaminza G, Saiz N, Gamboa PM, Vela C, et al. Lipid transfer protein syndrome in a non-Mediterranean area. Int Arch Allergy Immunol. 2016;169:181–8.CrossRefPubMed Azofra J, Berroa F, Gastaminza G, Saiz N, Gamboa PM, Vela C, et al. Lipid transfer protein syndrome in a non-Mediterranean area. Int Arch Allergy Immunol. 2016;169:181–8.CrossRefPubMed
14.
Zurück zum Zitat Cuesta-Herranz J, Barber D, Blanco C, Cistero-Bahíma A, Crespo JF, Fernández-Rivas M, et al. Differences among pollen-allergic patients with and without plant food allergy. Int Arch Allergy Immunol. 2010;153:182–92.CrossRefPubMed Cuesta-Herranz J, Barber D, Blanco C, Cistero-Bahíma A, Crespo JF, Fernández-Rivas M, et al. Differences among pollen-allergic patients with and without plant food allergy. Int Arch Allergy Immunol. 2010;153:182–92.CrossRefPubMed
15.
Zurück zum Zitat Pastorello EA, Robino AM. Clinical role of lipid transfer proteins in food allergy. Mol Nutr Food Res. 2004;48:356–62.CrossRefPubMed Pastorello EA, Robino AM. Clinical role of lipid transfer proteins in food allergy. Mol Nutr Food Res. 2004;48:356–62.CrossRefPubMed
16.
Zurück zum Zitat Lombardero M, García-Sellés FJ, Polo F, Jimeno L, Chamorro MJ, García-Casado G, et al. Prevalence of sensitization to Artemisia allergens art v 1, art v 3 and art v 60 kDa. Cross-reactivity among art v 3 and other relevant lipid-transfer protein allergens. Clin Exp Allergy. 2004;34:1415–21.CrossRefPubMed Lombardero M, García-Sellés FJ, Polo F, Jimeno L, Chamorro MJ, García-Casado G, et al. Prevalence of sensitization to Artemisia allergens art v 1, art v 3 and art v 60 kDa. Cross-reactivity among art v 3 and other relevant lipid-transfer protein allergens. Clin Exp Allergy. 2004;34:1415–21.CrossRefPubMed
17.
Zurück zum Zitat Lauer I, Miguel-Moncin MS, Abel T, Foetisch K, Hartz C, Fortunato D, et al. Identification of a plane pollen lipid transfer protein (Pla a 3) and its immunological relation to the peach lipid-transfer protein, Pru p 3. Clin Exp Allergy. 2007;37:261–9.CrossRefPubMed Lauer I, Miguel-Moncin MS, Abel T, Foetisch K, Hartz C, Fortunato D, et al. Identification of a plane pollen lipid transfer protein (Pla a 3) and its immunological relation to the peach lipid-transfer protein, Pru p 3. Clin Exp Allergy. 2007;37:261–9.CrossRefPubMed
18.
Zurück zum Zitat Palacín A, Gómez-Casado C, Rivas LA, Aguirre J, Tordesillas L, Bartra J, et al. Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. PLoS One. 2012;7(12):e50799.CrossRefPubMedPubMedCentral Palacín A, Gómez-Casado C, Rivas LA, Aguirre J, Tordesillas L, Bartra J, et al. Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. PLoS One. 2012;7(12):e50799.CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Gao ZS, Yang ZW, Wu SD, Wang HY, Liu ML, Mao WL, et al. Peach allergy in China: a dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. J Allergy Clin Immunol. 2013;131:224–6.CrossRefPubMed Gao ZS, Yang ZW, Wu SD, Wang HY, Liu ML, Mao WL, et al. Peach allergy in China: a dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. J Allergy Clin Immunol. 2013;131:224–6.CrossRefPubMed
20.
Zurück zum Zitat Pastorello EA, Pravettoni V, Farioli L, Ispano M, Fortunato D, Monza M, et al. Clinical role of a lipid transfer protein that acts as a new apple-specific allergen. J Allergy Clin Immunol. 1999;104:1099–106.CrossRefPubMed Pastorello EA, Pravettoni V, Farioli L, Ispano M, Fortunato D, Monza M, et al. Clinical role of a lipid transfer protein that acts as a new apple-specific allergen. J Allergy Clin Immunol. 1999;104:1099–106.CrossRefPubMed
22.
Zurück zum Zitat Tabar AI, Alvarez-Puebla MJ, Gomez B, Sanchez-Monge R, García BE, Echechipia S, et al. Diversity of asparagus allergy: clinical and immunological features. Clin Exp Allergy. 2004;34:131–6.CrossRefPubMed Tabar AI, Alvarez-Puebla MJ, Gomez B, Sanchez-Monge R, García BE, Echechipia S, et al. Diversity of asparagus allergy: clinical and immunological features. Clin Exp Allergy. 2004;34:131–6.CrossRefPubMed
23.
Zurück zum Zitat Palacín A, Cumplido J, Figueroa J, Ahrazem O, Sánchez-Monge R, Carrillo T, et al. Cabbage lipid transfer protein Bra o 3 is a major allergen responsible for cross-reactivity between plant foods and pollens. J Allergy Clin Immunol. 2006;117:1423–9.CrossRefPubMed Palacín A, Cumplido J, Figueroa J, Ahrazem O, Sánchez-Monge R, Carrillo T, et al. Cabbage lipid transfer protein Bra o 3 is a major allergen responsible for cross-reactivity between plant foods and pollens. J Allergy Clin Immunol. 2006;117:1423–9.CrossRefPubMed
24.
Zurück zum Zitat Sánchez-Monge R, Blanco C, López-Torrejón G, Cumplido J, Recas M, Figueroa J, et al. Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome. J Allergy Clin Immunol. 2006;118:705–10.CrossRefPubMed Sánchez-Monge R, Blanco C, López-Torrejón G, Cumplido J, Recas M, Figueroa J, et al. Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome. J Allergy Clin Immunol. 2006;118:705–10.CrossRefPubMed
25.
Zurück zum Zitat Pastorello EA, Farioli L, Pravettoni V, Ortolani C, Fortunato D, Giuffrida MG, et al. Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin. J Allergy Clin Immunol. 2003;111:350–9.CrossRefPubMed Pastorello EA, Farioli L, Pravettoni V, Ortolani C, Fortunato D, Giuffrida MG, et al. Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin. J Allergy Clin Immunol. 2003;111:350–9.CrossRefPubMed
26.
Zurück zum Zitat Schad SG, Trcka J, Vieths S, Scheurer S, Conti A, Brocker EB, et al. Wine anaphylaxis in a German patient: IgE-mediated allergy against a lipid transfer protein of grapes. Int Arch Allergy Immunol. 2005;136:159–64.CrossRefPubMed Schad SG, Trcka J, Vieths S, Scheurer S, Conti A, Brocker EB, et al. Wine anaphylaxis in a German patient: IgE-mediated allergy against a lipid transfer protein of grapes. Int Arch Allergy Immunol. 2005;136:159–64.CrossRefPubMed
27.
Zurück zum Zitat Zoccatelli G, Pokoj S, Foetisch K, Bartra J, Valero A, Del Mar San Miguel-Moncin M, et al. Identification and characterization of the major allergen of green bean (Phaseolus vulgaris) as a non-specific lipid transfer protein (Pha v 3). Mol Immunol. 2010;47:1561–8.CrossRefPubMed Zoccatelli G, Pokoj S, Foetisch K, Bartra J, Valero A, Del Mar San Miguel-Moncin M, et al. Identification and characterization of the major allergen of green bean (Phaseolus vulgaris) as a non-specific lipid transfer protein (Pha v 3). Mol Immunol. 2010;47:1561–8.CrossRefPubMed
28.
Zurück zum Zitat Pastorello EA, Pravettoni V, Farioli L, Rivolta F, Conti A, Ispano M, et al. Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression. J Allergy Clin Immunol. 2002;110:310–7.CrossRefPubMed Pastorello EA, Pravettoni V, Farioli L, Rivolta F, Conti A, Ispano M, et al. Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression. J Allergy Clin Immunol. 2002;110:310–7.CrossRefPubMed
29.
Zurück zum Zitat Hansen KS, Ballmer-Weber BK, Sastre J, Lidholm J, Andersson K, Oberhofer H, et al. Component-resolved in vitro diagnosis of hazelnut allergy in Europe. J Allergy Clin Immunol. 2009;123:1134–41.CrossRefPubMed Hansen KS, Ballmer-Weber BK, Sastre J, Lidholm J, Andersson K, Oberhofer H, et al. Component-resolved in vitro diagnosis of hazelnut allergy in Europe. J Allergy Clin Immunol. 2009;123:1134–41.CrossRefPubMed
30.
Zurück zum Zitat Le TM, Bublin M, Breiteneder H, Fernández-Rivas M, Asero R, Ballmer-Weber B, et al. Kiwifruit allergy across Europe: clinical manifestation and IgE recognition patterns to kiwifruit allergens. J Allergy Clin Immunol. 2013;131:164–71.CrossRefPubMed Le TM, Bublin M, Breiteneder H, Fernández-Rivas M, Asero R, Ballmer-Weber B, et al. Kiwifruit allergy across Europe: clinical manifestation and IgE recognition patterns to kiwifruit allergens. J Allergy Clin Immunol. 2013;131:164–71.CrossRefPubMed
31.
Zurück zum Zitat Akkerdaas J, Finkina EI, Balandin SV, Santos Magadán S, Knulst A, Fernandez-Rivas M, et al. Lentil (Lens culinaris) lipid transfer protein Len c 3: a novel legume allergen. Int Arch Allergy Immunol. 2012;157:51–7.CrossRefPubMed Akkerdaas J, Finkina EI, Balandin SV, Santos Magadán S, Knulst A, Fernandez-Rivas M, et al. Lentil (Lens culinaris) lipid transfer protein Len c 3: a novel legume allergen. Int Arch Allergy Immunol. 2012;157:51–7.CrossRefPubMed
32.
Zurück zum Zitat San Miguel-Moncín M, Krail M, Scheurer S, Enrique E, Alonso R, Conti A, et al. Lettuce anaphylaxis: identification of a lipid transfer protein as the major allergen. Allergy. 2003;58:511–7.CrossRefPubMed San Miguel-Moncín M, Krail M, Scheurer S, Enrique E, Alonso R, Conti A, et al. Lettuce anaphylaxis: identification of a lipid transfer protein as the major allergen. Allergy. 2003;58:511–7.CrossRefPubMed
33.
Zurück zum Zitat Antolin-Amerigo D, Rodríguez-Rodríguez M, Barbarroja-Escudero J, Sánchez-González MJ, Haroun-Díaz E, Cuesta-Herranz J, et al. Linseed Allergy Due to LTP: Another Food for LTP Syndrome. J Investig Allergol Clin Immunol. 2016;26:376–7.CrossRefPubMed Antolin-Amerigo D, Rodríguez-Rodríguez M, Barbarroja-Escudero J, Sánchez-González MJ, Haroun-Díaz E, Cuesta-Herranz J, et al. Linseed Allergy Due to LTP: Another Food for LTP Syndrome. J Investig Allergol Clin Immunol. 2016;26:376–7.CrossRefPubMed
34.
Zurück zum Zitat Guillen D, Barranco P, Palacín A, Quirce S. Occupational rhinoconjunctivitis due to maize in a snack processor: a cross-reactivity study between lipid transfer proteins from different cereals and peach. Allergy Asthma Immunol Res. 2014;6:470–3.CrossRefPubMedPubMedCentral Guillen D, Barranco P, Palacín A, Quirce S. Occupational rhinoconjunctivitis due to maize in a snack processor: a cross-reactivity study between lipid transfer proteins from different cereals and peach. Allergy Asthma Immunol Res. 2014;6:470–3.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Ebo DG, Ahrazem O, Lopez-Torrejon G, Bridts CH, Salcedo G, Stevens WJ. Anaphylaxis from mandarin (Citrus reticulata): identification of potential responsible allergens. Int Arch Allergy Immunol. 2007;144:39–43.CrossRefPubMed Ebo DG, Ahrazem O, Lopez-Torrejon G, Bridts CH, Salcedo G, Stevens WJ. Anaphylaxis from mandarin (Citrus reticulata): identification of potential responsible allergens. Int Arch Allergy Immunol. 2007;144:39–43.CrossRefPubMed
36.
Zurück zum Zitat Sirvent S, Palomares O, Vereda A, Villalba M, Cuesta-Herranz J, Rodríguez R. nsLTP and profilin are allergens in mustard seeds: cloning, sequencing and recombinant production of sin a 3 and sin a 4. Clin Exp Allergy. 2009;39:1929–36.CrossRefPubMed Sirvent S, Palomares O, Vereda A, Villalba M, Cuesta-Herranz J, Rodríguez R. nsLTP and profilin are allergens in mustard seeds: cloning, sequencing and recombinant production of sin a 3 and sin a 4. Clin Exp Allergy. 2009;39:1929–36.CrossRefPubMed
37.
Zurück zum Zitat Vereda A, Sirvent S, Villalba M, Rodríguez R, Cuesta-Herranz J, Palomares O. Improvement of mustard (Sinapis alba) allergy diagnosis and management by linking clinical features and component-resolved approaches. J Allergy Clin Immunol. 2011;127:1304–7.CrossRefPubMed Vereda A, Sirvent S, Villalba M, Rodríguez R, Cuesta-Herranz J, Palomares O. Improvement of mustard (Sinapis alba) allergy diagnosis and management by linking clinical features and component-resolved approaches. J Allergy Clin Immunol. 2011;127:1304–7.CrossRefPubMed
38.
Zurück zum Zitat Ahrazem O, Ibáñez MD, López-Torrejón G, Sánchez-Monge R, Sastre J, Lombardero M, et al. Lipid transfer proteins and allergy to oranges. Int Arch Allergy Immunol. 2005;137:201–10.CrossRefPubMed Ahrazem O, Ibáñez MD, López-Torrejón G, Sánchez-Monge R, Sastre J, Lombardero M, et al. Lipid transfer proteins and allergy to oranges. Int Arch Allergy Immunol. 2005;137:201–10.CrossRefPubMed
39.
Zurück zum Zitat Krause S, Reese G, Randow S, Zennaro D, Quaratino D, Palazzo P, et al. Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population. J Allergy Clin Immunol. 2009;124:771–8.CrossRefPubMed Krause S, Reese G, Randow S, Zennaro D, Quaratino D, Palazzo P, et al. Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population. J Allergy Clin Immunol. 2009;124:771–8.CrossRefPubMed
40.
Zurück zum Zitat Enrique E, Utz M, De Mateo JA, Castelló JV, Malek T, Pineda F. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol. 2006;96:122–3.CrossRefPubMed Enrique E, Utz M, De Mateo JA, Castelló JV, Malek T, Pineda F. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol. 2006;96:122–3.CrossRefPubMed
41.
Zurück zum Zitat Le LQ LY, Scheurer S, Fötisch K, Enrique E, Bartra J, et al. Design of tomato fruits with reduced allergenicity by dsRNAi-mediated inhibition of ns-LTP (Lyc e 3) expression. Plant Biotechnol J. 2006;4:231–42.CrossRef Le LQ LY, Scheurer S, Fötisch K, Enrique E, Bartra J, et al. Design of tomato fruits with reduced allergenicity by dsRNAi-mediated inhibition of ns-LTP (Lyc e 3) expression. Plant Biotechnol J. 2006;4:231–42.CrossRef
42.
Zurück zum Zitat Pastorello EA, Farioli L, Pravettoni V, Robino AM, Scibilia J, Fortunato D, et al. Lipid transfer protein and vicilin are important walnut allergens in patients not allergic to pollen. J Allergy Clin Immunol. 2004;114:908–14.CrossRefPubMed Pastorello EA, Farioli L, Pravettoni V, Robino AM, Scibilia J, Fortunato D, et al. Lipid transfer protein and vicilin are important walnut allergens in patients not allergic to pollen. J Allergy Clin Immunol. 2004;114:908–14.CrossRefPubMed
43.
Zurück zum Zitat Palacin A, Quirce S, Armentia A, Fernández-Nieto M, Pacios LF, Asensio T, et al. Wheat lipid transfer protein is a major allergen associated with baker’s asthma. J Allergy Clin Immunol. 2007;120(5):1132–8.CrossRefPubMed Palacin A, Quirce S, Armentia A, Fernández-Nieto M, Pacios LF, Asensio T, et al. Wheat lipid transfer protein is a major allergen associated with baker’s asthma. J Allergy Clin Immunol. 2007;120(5):1132–8.CrossRefPubMed
44.
Zurück zum Zitat Murad A, Katelaris CH, Baumgart K. A case study of apple seed and grape allergy with sensitisation to nonspecific lipid transfer protein. Asia Pac Allergy. 2016;6:129–32.CrossRefPubMedPubMedCentral Murad A, Katelaris CH, Baumgart K. A case study of apple seed and grape allergy with sensitisation to nonspecific lipid transfer protein. Asia Pac Allergy. 2016;6:129–32.CrossRefPubMedPubMedCentral
45.
Zurück zum Zitat Sánchez-López J, Asturias JA, Enrique E, Suárez-Cervera M, Bartra J. Cupressus arizonica pollen: a new pollen involved in the lipid transfer protein syndrome? J Investig Allergol Clin Immunol. 2011;2:522–6. Sánchez-López J, Asturias JA, Enrique E, Suárez-Cervera M, Bartra J. Cupressus arizonica pollen: a new pollen involved in the lipid transfer protein syndrome? J Investig Allergol Clin Immunol. 2011;2:522–6.
46.
Zurück zum Zitat Palacin A, Varela J, Quirce S, del Pozo V, Tordesillas L, Barranco P, et al. Recombinant lipid transfer protein tri a 14: a novel heat and proteolytic resistant tool for the diagnosis of baker’s asthma. Clin Exp Allergy. 2009;39(8):1267–76.CrossRefPubMed Palacin A, Varela J, Quirce S, del Pozo V, Tordesillas L, Barranco P, et al. Recombinant lipid transfer protein tri a 14: a novel heat and proteolytic resistant tool for the diagnosis of baker’s asthma. Clin Exp Allergy. 2009;39(8):1267–76.CrossRefPubMed
47.
Zurück zum Zitat Pérez-Calderón R, Gonzalo-Garijo MÁ, Rodríguez-Velasco FJ, Sánchez-Vega S, Bartolomé-Zavala B. Occupational respiratory allergy in peach crop workers. Allergy. 2017;72:1556–64.CrossRefPubMed Pérez-Calderón R, Gonzalo-Garijo MÁ, Rodríguez-Velasco FJ, Sánchez-Vega S, Bartolomé-Zavala B. Occupational respiratory allergy in peach crop workers. Allergy. 2017;72:1556–64.CrossRefPubMed
48.
Zurück zum Zitat • Zuidmeer L, Van Ree R. Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. Curr Opin Allergy Clin Immunol. 2007;7:269–73. A review article on LTP allergy. CrossRefPubMed • Zuidmeer L, Van Ree R. Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. Curr Opin Allergy Clin Immunol. 2007;7:269–73. A review article on LTP allergy. CrossRefPubMed
49.
Zurück zum Zitat Asero R, Antonicelli L, Arena A, Bommarito L, Caruso B, Crivellaro M, et al. EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multicentre study. Clin Exp Allergy. 2009;39:547–55.CrossRefPubMed Asero R, Antonicelli L, Arena A, Bommarito L, Caruso B, Crivellaro M, et al. EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multicentre study. Clin Exp Allergy. 2009;39:547–55.CrossRefPubMed
50.
Zurück zum Zitat Haroun-Díaz E, Azofra J, González-Mancebo E, de Las Heras M, Pastor-Vargas C, Esteban V, et al. Nut allergy in two different areas of Spain: differences in clinical and molecular pattern. Nutrients. 2017;21:9. Haroun-Díaz E, Azofra J, González-Mancebo E, de Las Heras M, Pastor-Vargas C, Esteban V, et al. Nut allergy in two different areas of Spain: differences in clinical and molecular pattern. Nutrients. 2017;21:9.
52.
Zurück zum Zitat Fernández-Rivas M, Garrido Fernández S, Nadal JA, Díaz de Durana MD, García BE, González-Mancebo E, et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy. 2009;64:876–83.CrossRefPubMed Fernández-Rivas M, Garrido Fernández S, Nadal JA, Díaz de Durana MD, García BE, González-Mancebo E, et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy. 2009;64:876–83.CrossRefPubMed
Metadaten
Titel
Food Allergies Caused by Allergenic Lipid Transfer Proteins: What Is behind the Geographic Restriction?
verfasst von
M. J. Rial
J. Sastre
Publikationsdatum
01.11.2018
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 11/2018
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-018-0810-x

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