Forensic Toxicology 1/2019

Open Access 01.01.2019 | Review Article

The search for the “next” euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning

Kirti Kumari Sharma, Tim G. Hales, Vaidya Jayathirtha Rao, Niamh NicDaeid, Craig McKenzie

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01.01.2019 | Original Article

Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures

Richard C. Kevin, Alexander L. Kovach, Timothy W. Lefever, Thomas F. Gamage, Jenny L. Wiley, Iain S. McGregor, Brian F. Thomas

Open Access 01.01.2019 | Original Article

Postmortem distribution of mepirapim and acetyl fentanyl in biological fluid and solid tissue specimens measured by the standard addition method

Akira Mochizuki, Hiroko Nakazawa, Noboru Adachi, Kenichi Takekawa, Hideki Shojo

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01.01.2019 | Original Article

Rapid tentative identification of synthetic cathinones in seized products taking advantage of the full capabilities of triple quadrupole analyzer

David Fabregat-Safont, Juan V. Sancho, Félix Hernández, María Ibáñez

Open Access 01.01.2019 | Original Article

Effects of exposure to 5-MeO-DIPT during adolescence on brain neurotransmission and neurotoxicity in adult rats

Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Joanna Rzemieniec, Agnieszka Wnuk, Jakub Wojcieszak, Anna Maria Górska, Grzegorz Kreiner, Małgorzata Kajta, Krystyna Gołembiowska

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01.01.2019 | Original Article

Interpreting oral fluid drug results in prisoners: monitoring current drug intake and detection times for drugs self-administered prior to detention

Elisabeth Leere Øiestad, Hege-Merete Krabseth, Marilyn Ann Huestis, Andreas Skulberg, Vigdis Vindenes

Open Access 01.01.2019 | Original Article

A new and sensitive method for quantitative determination of helium in human blood by gas chromatography–mass spectrometry using naturally existing neon-21 as internal standard

Akira Tsujita, Hidehiko Okazaki, Asami Nagasaka, Akinaga Gohda, Mitsushi Matsumoto, Toshiro Matsui

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01.01.2019 | Original Article

NBOMe instability in whole blood

Kelly Francisco da Cunha, Marcos Nogueira Eberlin, Marilyn A. Huestis, José Luiz Costa

01.01.2019 | Original Article

Detection of in utero ethanol exposure via ethyl glucuronide and ethyl sulfate analysis in umbilical cord and placenta

Jennifer Hanna, Elena Lendoiro, Ana de Castro, Eva Gónzalez-Colmenero, Ana Concheiro-Guisan, Patricia Peñas-Silva, Manuel Macias-Cortiña, Angelines Cruz-Landeira, Manuel López-Rivadulla, Marta Concheiro-Guisan

01.01.2019 | Original Article

Effects of aromatic ring-substituted phenethylamines on the release of dopamine and serotonin

Minjeong Kim, Chae Ha Yang, Yong Sup Lee, Choon-Gon Jang, Seikwan Oh, Sooyeun Lee

01.01.2019 | Original Article

Liquid chromatography–mass spectrometry studies on the isomeric 1-fluorobenzyl-3-naphthoyl-indoles: FUB-JWH-018 and five isomers

Takao Chikumoto, Ryoichi Furukawa, Erina Kohyama, Koichi Suenami, Hiroyuki Nagai, Hiroyuki Tada, Hidenobu Kawashima, Natsuki Kadomura, Midori Soda, Kiyoyuki Kitaichi, Tetsuro Ito

01.01.2019 | Original Article

Simultaneous determination of selegiline, desmethylselegiline, R/S-methamphetamine, and R/S-amphetamine in oral fluid by LC/MS/MS

Lizhu Chen, Yingjia Yu, Yang Wang, Ping Xiang, Gengli Duan

01.01.2019 | Original Article

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

Matteo Marti, Margherita Neri, Sabrine Bilel, Marco Di Paolo, Raffaele La Russa, Andrea Ossato, Emanuela Turillazzi

01.01.2019 | Original Article

Simultaneous chiral impurity analysis of methamphetamine and its precursors by supercritical fluid chromatography–tandem mass spectrometry

Hiroki Segawa, Yuko T. Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue

Open Access 01.01.2019 | Original Article

Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE

Lukas Mogler, Sebastian Halter, Maurice Wilde, Florian Franz, Volker Auwärter

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Open Access 01.01.2019 | Original Article

Sensitive quantification of BB-22 and its metabolite BB-22 3-carboxyindole, and characterization of new metabolites in authentic urine and/or serum specimens obtained from three individuals by LC–QTRAP-MS/MS and high-resolution LC–Orbitrap-MS/MS

Kayoko Minakata, Koutaro Hasegawa, Hideki Nozawa, Itaru Yamagishi, Takeji Saitoh, Atsuto Yoshino, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe

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01.01.2019 | Original Article

Metabolism of triacetone triperoxide (TATP) by canine cytochrome P450 2B11

Kevin Colizza, Michelle Gonsalves, Lindsay McLennan, James L. Smith, Jimmie C. Oxley

Open Access 01.01.2019 | Original Article

5F-Cumyl-PINACA in ‘e-liquids’ for electronic cigarettes: comprehensive characterization of a new type of synthetic cannabinoid in a trendy product including investigations on the in vitro and in vivo phase I metabolism of 5F-Cumyl-PINACA and its non-fluorinated analog Cumyl-PINACA

Verena Angerer, Florian Franz, Bjoern Moosmann, Philippe Bisel, Volker Auwärter

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Open Access 01.01.2019 | Original Article

Forensic analysis using ultra-high-performance liquid chromatography–tandem mass spectrometry with solid-phase extraction of α-solanine and α-chaconine in whole blood

Akina Nara, Kanju Saka, Chiho Yamada, Takanori Kodama, Tetsuya Takagi

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Open Access 01.01.2019 | Original Article

∆9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor

Toshiyuki Kimura, Makiko Takaya, Noriyuki Usami, Kazuhito Watanabe, Ikuo Yamamoto

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01.01.2019 | Original Article

Quantification of seven novel synthetic opioids in blood using LC–MS/MS

Janna Lowry, Michael T. Truver, Madeleine J. Swortwood

Open Access 01.01.2019 | Short Communication

Crystal structures and other properties of ephedrone (methcathinone) hydrochloride, N-acetylephedrine and N-acetylephedrone

Piotr Kuś, Hubert Hellwig, Joachim Kusz, Maria Książek, Marcin Rojkiewicz, Aleksander Sochanik

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01.01.2019 | Short Communication

Immunoassay-based detection of fentanyl analogs in forensic toxicology

Madison Schackmuth, Sarah Kerrigan

Open Access 01.01.2019 | Short Communication

A GC–MS method for the determination of furanylfentanyl and ocfentanil in whole blood with full validation

Nektaria Misailidi, Sotiris Athanaselis, Panagiota Nikolaou, Maria Katselou, Yannis Dotsikas, Chara Spiliopoulou, Ioannis Papoutsis

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01.01.2019 | Case Report

Fatal intoxication with 1,1-difluoroethane (DFE) due to inhalation of a spray cleaner: analysis by GC–MS

Suguru Torimitsu, Yusuke Fujii, Kanju Saka, Hiroko Abe, Yohsuke Makino, Fumiko Chiba, Hirotaro Iwase

01.01.2019 | Case Report

Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8

Yoshiaki Iwamuro, Takaya Murakami, Reiko Ishimaru, Satoshi Chinaka

01.01.2019 | Letter to the Editor

Use of polysaccharide-based chiral columns: enantiomeric separation of seven pairs of abused drugs by high-performance liquid chromatography–mass spectrometry

Tajudheen K. Karatt, Abdul Khader Karakka Kal, Ramy Sayed, Jahfar Nalakath, Zubair Perwad

Open Access 01.01.2019 | Letter to the Editor

Unstability of 4-CMC in human serum specimen

Karolina Nowak, Paweł Szpot, Marcin Zawadzki

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01.01.2019 | Letter to the Editor

Profile of new psychoactive substances (NPS) and other synthetic drugs in seized materials analysed in a Brazilian forensic laboratory

Yuri Machado, José Coelho Neto, Rogério Araújo Lordeiro, Monique Ferreira Silva, Evandro Piccin

Springer Medizin

Inhaltsverzeichnis (29 Artikel)

The search for the “next” euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning

Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures

Postmortem distribution of mepirapim and acetyl fentanyl in biological fluid and solid tissue specimens measured by the standard addition method

Rapid tentative identification of synthetic cathinones in seized products taking advantage of the full capabilities of triple quadrupole analyzer

Effects of exposure to 5-MeO-DIPT during adolescence on brain neurotransmission and neurotoxicity in adult rats

Interpreting oral fluid drug results in prisoners: monitoring current drug intake and detection times for drugs self-administered prior to detention

A new and sensitive method for quantitative determination of helium in human blood by gas chromatography–mass spectrometry using naturally existing neon-21 as internal standard

NBOMe instability in whole blood

Detection of in utero ethanol exposure via ethyl glucuronide and ethyl sulfate analysis in umbilical cord and placenta

Effects of aromatic ring-substituted phenethylamines on the release of dopamine and serotonin

Liquid chromatography–mass spectrometry studies on the isomeric 1-fluorobenzyl-3-naphthoyl-indoles: FUB-JWH-018 and five isomers

Simultaneous determination of selegiline, desmethylselegiline, R/S-methamphetamine, and R/S-amphetamine in oral fluid by LC/MS/MS

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

Simultaneous chiral impurity analysis of methamphetamine and its precursors by supercritical fluid chromatography–tandem mass spectrometry

Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE

Sensitive quantification of BB-22 and its metabolite BB-22 3-carboxyindole, and characterization of new metabolites in authentic urine and/or serum specimens obtained from three individuals by LC–QTRAP-MS/MS and high-resolution LC–Orbitrap-MS/MS

Metabolism of triacetone triperoxide (TATP) by canine cytochrome P450 2B11

5F-Cumyl-PINACA in ‘e-liquids’ for electronic cigarettes: comprehensive characterization of a new type of synthetic cannabinoid in a trendy product including investigations on the in vitro and in vivo phase I metabolism of 5F-Cumyl-PINACA and its non-fluorinated analog Cumyl-PINACA

Forensic analysis using ultra-high-performance liquid chromatography–tandem mass spectrometry with solid-phase extraction of α-solanine and α-chaconine in whole blood

∆9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor

Quantification of seven novel synthetic opioids in blood using LC–MS/MS

Crystal structures and other properties of ephedrone (methcathinone) hydrochloride, N-acetylephedrine and N-acetylephedrone

Immunoassay-based detection of fentanyl analogs in forensic toxicology

A GC–MS method for the determination of furanylfentanyl and ocfentanil in whole blood with full validation

Fatal intoxication with 1,1-difluoroethane (DFE) due to inhalation of a spray cleaner: analysis by GC–MS

Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8

Use of polysaccharide-based chiral columns: enantiomeric separation of seven pairs of abused drugs by high-performance liquid chromatography–mass spectrometry

Unstability of 4-CMC in human serum specimen

Profile of new psychoactive substances (NPS) and other synthetic drugs in seized materials analysed in a Brazilian forensic laboratory

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