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Erschienen in: European Child & Adolescent Psychiatry 2/2015

01.02.2015 | Original Contribution

Formal thought disorder in autism spectrum disorder predicts future symptom severity, but not psychosis prodrome

verfasst von: Mart L. J. M. Eussen, Esther I. de Bruin, Arthur R. Van Gool, Anneke Louwerse, Jan van der Ende, Fop Verheij, Frank C. Verhulst, Kirstin Greaves-Lord

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 2/2015

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Abstract

Formal thought disorder (FTD) is a disruption in the flow of thought, which is inferred from disorganisation of spoken language. FTD in autism spectrum disorders (ASD) might be a precursor of psychotic disorders or a manifestation of ASD symptom severity. The current longitudinal study is a seven-year follow-up of 91 individuals aged 5–12 years with ASD. We tested (1) whether childhood FTD predicted prodromal symptoms of psychosis in adolescence and (2) whether childhood FTD was associated with greater ASD symptom severity in adolescence. ASD symptom severity was assessed in childhood (T1) and 7 years later (T2), using the autism diagnostic observation schedule (ADOS). At T1, the Kiddie-Formal Thought Disorder Rating Scale (KFTDS) was used to measure symptoms of FTD. At T2, the prodromal questionnaire (PQ) was used to assess prodromal symptoms of psychosis. FTD at T1 did not predict prodromal symptoms of psychosis at T2 in children with ASD. FTD symptoms at T1, namely illogical thinking, predicted ASD symptom severity at T2 and this effect remained significant after controlling for T1 ASD symptom severity. In children with ASD, illogical thinking predicts severity of ASD symptoms in adolescence, but FTD does not predict prodromal symptoms of psychosis.
Literatur
1.
Zurück zum Zitat Dochterty NM, McCleery A, Divilbiss M, Schumann EB, Moe A, Shakeel MK (2013) Effects of social cognitive impairment on speech disorder in schizophrenia. Schizophr Res 39(3):608–616CrossRef Dochterty NM, McCleery A, Divilbiss M, Schumann EB, Moe A, Shakeel MK (2013) Effects of social cognitive impairment on speech disorder in schizophrenia. Schizophr Res 39(3):608–616CrossRef
2.
Zurück zum Zitat Caplan R (1994) Thought disorder in childhood. J Am Acad Child Adolesc Psychiatry 33(5):605–615PubMedCrossRef Caplan R (1994) Thought disorder in childhood. J Am Acad Child Adolesc Psychiatry 33(5):605–615PubMedCrossRef
3.
Zurück zum Zitat Bearden CE, Wu KN, Caplan R, Cannon TD (2011) Thought disorder and communication deviance as predictors of outcome in youth at clinical high risk for psychosis. J Am Acad Child Adolesc Psychiatry 50(7):669–680PubMedCentralPubMedCrossRef Bearden CE, Wu KN, Caplan R, Cannon TD (2011) Thought disorder and communication deviance as predictors of outcome in youth at clinical high risk for psychosis. J Am Acad Child Adolesc Psychiatry 50(7):669–680PubMedCentralPubMedCrossRef
4.
Zurück zum Zitat Ozonoff S, Pennington B, Solomon M (2006) Neuropsychological perspectives on developmental psychopathology. In: Cichetti D, Cohen D (eds) Developmental psychopathology, vol 2: developmental neuroscience, 2nd edn. John Wiley & Sons Inc, Hoboken, pp 332–380 Ozonoff S, Pennington B, Solomon M (2006) Neuropsychological perspectives on developmental psychopathology. In: Cichetti D, Cohen D (eds) Developmental psychopathology, vol 2: developmental neuroscience, 2nd edn. John Wiley & Sons Inc, Hoboken, pp 332–380
6.
Zurück zum Zitat Caplan R, Guthrie D, Komo S, Siddarth P, Chayasirisobhon S, Kornblum H, Sankar R, Hansen R, Mitchell W, Shields WD (2002) Social communication in children with epilepsy. J Child Psychol Psychiatry 43(2):245–253PubMedCrossRef Caplan R, Guthrie D, Komo S, Siddarth P, Chayasirisobhon S, Kornblum H, Sankar R, Hansen R, Mitchell W, Shields WD (2002) Social communication in children with epilepsy. J Child Psychol Psychiatry 43(2):245–253PubMedCrossRef
7.
Zurück zum Zitat Andreasen NC (1979) Thought, language and communication disorders. Arch Gen Psychiatry 36:1315–1321PubMedCrossRef Andreasen NC (1979) Thought, language and communication disorders. Arch Gen Psychiatry 36:1315–1321PubMedCrossRef
8.
Zurück zum Zitat Caplan R, Guthrie D, Fish B, Tanguay PE, David-Lando G (1989) The Kiddie formal thought disorder rating scale: clinical assessment, reliability, and validity. J Am Acad Child Adolesc Psychiatr 28(3):408–417CrossRef Caplan R, Guthrie D, Fish B, Tanguay PE, David-Lando G (1989) The Kiddie formal thought disorder rating scale: clinical assessment, reliability, and validity. J Am Acad Child Adolesc Psychiatr 28(3):408–417CrossRef
9.
Zurück zum Zitat Caplan R, Guthrie D, Tang B, Komo S, Asarnow RF (2000) Thought disorder in childhood schizophrenia: replication and update of concept. J Am Acad Child Adolesc Psychiatry 2000(39):771–778CrossRef Caplan R, Guthrie D, Tang B, Komo S, Asarnow RF (2000) Thought disorder in childhood schizophrenia: replication and update of concept. J Am Acad Child Adolesc Psychiatry 2000(39):771–778CrossRef
10.
Zurück zum Zitat Bleuler E (ed) (1950) Dementia praecox or the group of schizophrenia’s. International University Press, New York Bleuler E (ed) (1950) Dementia praecox or the group of schizophrenia’s. International University Press, New York
11.
Zurück zum Zitat Docherty NM, Gottesmann II (2000) A twin study of communication disturbances in schizophrenia. J Nerv Ment Dis 2000(188):395–401CrossRef Docherty NM, Gottesmann II (2000) A twin study of communication disturbances in schizophrenia. J Nerv Ment Dis 2000(188):395–401CrossRef
12.
Zurück zum Zitat Docherty NM (2005) Cognitive impairments and disordered speech in schizophrenia: thought disorder, disorganization, and communication failure perspectives. J Abnorm Psychol 114:269–278PubMedCrossRef Docherty NM (2005) Cognitive impairments and disordered speech in schizophrenia: thought disorder, disorganization, and communication failure perspectives. J Abnorm Psychol 114:269–278PubMedCrossRef
13.
Zurück zum Zitat Solomon M, Ozonoff S, Carter C, Caplan R (2008) Formal thought disorder and the autism spectrum: relationship with symptoms, executive control, and anxiety. J Autism Dev Disord 38:1474–1484PubMedCrossRef Solomon M, Ozonoff S, Carter C, Caplan R (2008) Formal thought disorder and the autism spectrum: relationship with symptoms, executive control, and anxiety. J Autism Dev Disord 38:1474–1484PubMedCrossRef
14.
Zurück zum Zitat Volden J, Lord C (1991) Neologisms and idiosyncratic language in autistic speakers. J Autism Dev Disord 21(2):109–130PubMedCrossRef Volden J, Lord C (1991) Neologisms and idiosyncratic language in autistic speakers. J Autism Dev Disord 21(2):109–130PubMedCrossRef
15.
Zurück zum Zitat Baltaxe CA, D’Angiola N (1992) Cohesion in the discourse interaction of autistic, specifically language-impaired, and normal children. J Autism Dev Disord 22(1):1–21PubMedCrossRef Baltaxe CA, D’Angiola N (1992) Cohesion in the discourse interaction of autistic, specifically language-impaired, and normal children. J Autism Dev Disord 22(1):1–21PubMedCrossRef
16.
Zurück zum Zitat Van der Gaag R, Caplan R, van Engeland H, Loman F, Buitelaar JK (2005) A controlled study of formal thought disorder in children with autism and multiple complex developmental disorders. J Child Adolesc Psychopharmacol 15(3):465–476PubMedCrossRef Van der Gaag R, Caplan R, van Engeland H, Loman F, Buitelaar JK (2005) A controlled study of formal thought disorder in children with autism and multiple complex developmental disorders. J Child Adolesc Psychopharmacol 15(3):465–476PubMedCrossRef
17.
Zurück zum Zitat Kanner L (1943) Autistic disturbances of affective contact. Nervous Child 1943(2):217–250 Kanner L (1943) Autistic disturbances of affective contact. Nervous Child 1943(2):217–250
18.
Zurück zum Zitat Rutter M (1972) Childhood schizophrenia reconsidered. J Autism Childhood Schizophrenia 2(4):315–337CrossRef Rutter M (1972) Childhood schizophrenia reconsidered. J Autism Childhood Schizophrenia 2(4):315–337CrossRef
19.
Zurück zum Zitat Volkmar FR, Cohen DJ (1991) Comorbid association of autism and schizophrenia. Am J Psychiatry 148(12):1705–1707PubMedCrossRef Volkmar FR, Cohen DJ (1991) Comorbid association of autism and schizophrenia. Am J Psychiatry 148(12):1705–1707PubMedCrossRef
20.
Zurück zum Zitat Bender L (1974) Psychopathic behaviour disorders in children. In: Lindner RM, Seliger RV (eds) Handbook of correctional psychology. Oxford Philosophical Library, Oxford, pp 360–377 Bender L (1974) Psychopathic behaviour disorders in children. In: Lindner RM, Seliger RV (eds) Handbook of correctional psychology. Oxford Philosophical Library, Oxford, pp 360–377
21.
22.
Zurück zum Zitat Rapaport J, Chavez A, Greenstein D, Addington A, Gogtay N (2009) Autism spectrum disorders and childhood onset schizophrenia: clinical and biological contributions to a relation revisited. J Am Acad Child Adolesc Psychiatry 48:10–18CrossRef Rapaport J, Chavez A, Greenstein D, Addington A, Gogtay N (2009) Autism spectrum disorders and childhood onset schizophrenia: clinical and biological contributions to a relation revisited. J Am Acad Child Adolesc Psychiatry 48:10–18CrossRef
23.
Zurück zum Zitat Wolff S (1991) ‘Schizoid’ personality in childhood and adult life. I: the vagaries of diagnostic labelling. III: The childhood picture. B. J Psychiatry 159(615–20):634–645 Wolff S (1991) ‘Schizoid’ personality in childhood and adult life. I: the vagaries of diagnostic labelling. III: The childhood picture. B. J Psychiatry 159(615–20):634–645
24.
Zurück zum Zitat Wolff S, McGuire RJ (1995) Schizoid personality in girls: a follow-up study–what are the links with Asperger’s syndrome. Child Psychol Psychiatry 36(5):793–817CrossRef Wolff S, McGuire RJ (1995) Schizoid personality in girls: a follow-up study–what are the links with Asperger’s syndrome. Child Psychol Psychiatry 36(5):793–817CrossRef
25.
Zurück zum Zitat Sporn AL, Addington AM, Gogtay N et al (2004) Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness? Biol Psychiatry 55(10):989–994PubMedCrossRef Sporn AL, Addington AM, Gogtay N et al (2004) Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness? Biol Psychiatry 55(10):989–994PubMedCrossRef
26.
Zurück zum Zitat Van der Gaag RJ, Buitelaar J, Van den Ban E, Bezemer M, Njio L, Van Engeland H (1995) A controlled multivariate chart review of multiple complex developmental disorder. J Am Acad Child Adolesc Psychiatry 34(8):1096–1106PubMedCrossRef Van der Gaag RJ, Buitelaar J, Van den Ban E, Bezemer M, Njio L, Van Engeland H (1995) A controlled multivariate chart review of multiple complex developmental disorder. J Am Acad Child Adolesc Psychiatry 34(8):1096–1106PubMedCrossRef
27.
Zurück zum Zitat Van Engeland H, Van der Gaag RJ (1994) MCDD in childhood: a precursor of schizophrenic spectrum disorder. Schizophr Res 11(2):197CrossRef Van Engeland H, Van der Gaag RJ (1994) MCDD in childhood: a precursor of schizophrenic spectrum disorder. Schizophr Res 11(2):197CrossRef
28.
Zurück zum Zitat Yung AR, McGorry PD (2007) Prediction of psychosis: setting the stage. B J Psychiatry 191(suppl. 51):s1–s8CrossRef Yung AR, McGorry PD (2007) Prediction of psychosis: setting the stage. B J Psychiatry 191(suppl. 51):s1–s8CrossRef
29.
Zurück zum Zitat Loewy RL, Bearden CE, Johnson JK, Raine A, Cannon TD, Tyrone D (2005) The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes. Schizophr Res 77:141–149PubMedCrossRef Loewy RL, Bearden CE, Johnson JK, Raine A, Cannon TD, Tyrone D (2005) The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes. Schizophr Res 77:141–149PubMedCrossRef
30.
Zurück zum Zitat Yung AR, Yuen HP, McGorry PD et al (2005) Mapping the onset of psychosis: the comprehensive assessment of at-risk mental states. Aust N Z J Psychiatry 39(11–12):964–971PubMedCrossRef Yung AR, Yuen HP, McGorry PD et al (2005) Mapping the onset of psychosis: the comprehensive assessment of at-risk mental states. Aust N Z J Psychiatry 39(11–12):964–971PubMedCrossRef
31.
Zurück zum Zitat Fusar-Poli P, Bonoldi I, Yung AR et al (2012) Predicting psychosis. Meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry 69:220–229PubMedCrossRef Fusar-Poli P, Bonoldi I, Yung AR et al (2012) Predicting psychosis. Meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry 69:220–229PubMedCrossRef
32.
Zurück zum Zitat Yung AR, Phillips LJ, Yuen HP et al (2003) Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophr Res 60(1):21–32PubMedCrossRef Yung AR, Phillips LJ, Yuen HP et al (2003) Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophr Res 60(1):21–32PubMedCrossRef
33.
Zurück zum Zitat Yung AR, Phillips LJ, Yuen HP, McGorry PD (2004) Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res 67(2–3):131–142PubMedCrossRef Yung AR, Phillips LJ, Yuen HP, McGorry PD (2004) Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res 67(2–3):131–142PubMedCrossRef
34.
Zurück zum Zitat Cannon TD, Cadenhead K, Comblatt B et al (2008) Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch Gen Psychiatry 65:28–37PubMedCentralPubMedCrossRef Cannon TD, Cadenhead K, Comblatt B et al (2008) Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch Gen Psychiatry 65:28–37PubMedCentralPubMedCrossRef
35.
Zurück zum Zitat American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, fourth edition, text revision. Author, Washington DCCrossRef American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, fourth edition, text revision. Author, Washington DCCrossRef
36.
Zurück zum Zitat De Bruin EI, De Nijs PF, Verheij F, Hartman CA, Ferdinand RF (2007) Multiple complex developmental disorder delineated from PDD-NOS. J Autism Dev Disord 37(6):1181–1191PubMedCrossRef De Bruin EI, De Nijs PF, Verheij F, Hartman CA, Ferdinand RF (2007) Multiple complex developmental disorder delineated from PDD-NOS. J Autism Dev Disord 37(6):1181–1191PubMedCrossRef
37.
Zurück zum Zitat Mandy W, Charman T, Skuse D (2012) Testing the construct validity of proposed criteria for DSM-5 autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 51:41–50PubMedCrossRef Mandy W, Charman T, Skuse D (2012) Testing the construct validity of proposed criteria for DSM-5 autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 51:41–50PubMedCrossRef
38.
Zurück zum Zitat Skuse DH (2012) DSM-5′s conceptualization of autistic disorders. J Am Acad Child Adolesc Psychiatry 51:344–346PubMedCrossRef Skuse DH (2012) DSM-5′s conceptualization of autistic disorders. J Am Acad Child Adolesc Psychiatry 51:344–346PubMedCrossRef
39.
Zurück zum Zitat Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME (2000) NIMH diagnostic interview schedule for children version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39(1):28–38PubMedCrossRef Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME (2000) NIMH diagnostic interview schedule for children version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39(1):28–38PubMedCrossRef
40.
Zurück zum Zitat Caplan R, Guthrie D, Tang B, Neuchterlein KH, Asarnow RE (2001) Thought disorder in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 40(8):965–972PubMedCrossRef Caplan R, Guthrie D, Tang B, Neuchterlein KH, Asarnow RE (2001) Thought disorder in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 40(8):965–972PubMedCrossRef
41.
Zurück zum Zitat Lord C, Rutter M, DiLavore PC, Risi S (1999) Autism diagnostic observation schedule-WPS (ADOS-WPS). Western Psychological Services, Los Angeles Lord C, Rutter M, DiLavore PC, Risi S (1999) Autism diagnostic observation schedule-WPS (ADOS-WPS). Western Psychological Services, Los Angeles
42.
Zurück zum Zitat Volkmar FR, State M, Klin A (2009) Autism and autism spectrum disorders: diagnostic issues for the coming decade. J Child Psychol Psychiatry 50(1–2):108–115PubMedCrossRef Volkmar FR, State M, Klin A (2009) Autism and autism spectrum disorders: diagnostic issues for the coming decade. J Child Psychol Psychiatry 50(1–2):108–115PubMedCrossRef
43.
Zurück zum Zitat Klosterkotter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58:158–164PubMedCrossRef Klosterkotter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58:158–164PubMedCrossRef
44.
Zurück zum Zitat WISC-R Projectgroep: Van Haasen, PP, De Bruyn EEJ, Pijl YJ, et al (1986) WISC-R. Wechsler Intelligence Scale for Children-Revised, Dutch version. Swets & Zeitlinger, Lisse WISC-R Projectgroep: Van Haasen, PP, De Bruyn EEJ, Pijl YJ, et al (1986) WISC-R. Wechsler Intelligence Scale for Children-Revised, Dutch version. Swets & Zeitlinger, Lisse
45.
Zurück zum Zitat Achenbach TM (1991) Manual for the child behavior Checklist/4-18 and 1991 profiles. Department of Psychiatry, University of Vermont, Burlington Achenbach TM (1991) Manual for the child behavior Checklist/4-18 and 1991 profiles. Department of Psychiatry, University of Vermont, Burlington
46.
Zurück zum Zitat Gadow KD (2012) Schizophrenia spectrum and attention-deficit/hyperactivity disorder symptoms in autism spectrum disorder and controls. J Am Acad Child Adolesc Psychiatry 51(10):1076–1084PubMedCrossRef Gadow KD (2012) Schizophrenia spectrum and attention-deficit/hyperactivity disorder symptoms in autism spectrum disorder and controls. J Am Acad Child Adolesc Psychiatry 51(10):1076–1084PubMedCrossRef
47.
Zurück zum Zitat Verhulst FC, van der Ende J, Handleiding ASEBA (2013) Vragenlijsten voor leeftijden 6 tot en met 18 jaar. ASEBA Nederland, Rotterdam Verhulst FC, van der Ende J, Handleiding ASEBA (2013) Vragenlijsten voor leeftijden 6 tot en met 18 jaar. ASEBA Nederland, Rotterdam
48.
Zurück zum Zitat Amone-P’Olak K, Ormel J, Oldehinkel A, Reijneveld SA, Verhulst FC, Burger H (2010) Socioeconomic position predicts special mental health service use independent of clinical severity: the TRAILS study. J Am Acad Child Adolesc Psychiatry 49(7):647–655PubMed Amone-P’Olak K, Ormel J, Oldehinkel A, Reijneveld SA, Verhulst FC, Burger H (2010) Socioeconomic position predicts special mental health service use independent of clinical severity: the TRAILS study. J Am Acad Child Adolesc Psychiatry 49(7):647–655PubMed
49.
Zurück zum Zitat Demjaha A, Valmaggia L, Stahl D, Byrne M, McGuire P (2012) Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis. Schizophr Bull 38(2):351–359PubMedCentralPubMedCrossRef Demjaha A, Valmaggia L, Stahl D, Byrne M, McGuire P (2012) Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis. Schizophr Bull 38(2):351–359PubMedCentralPubMedCrossRef
50.
Zurück zum Zitat Armenteros JL, Davies M (2006) Anti-psychotics in early onset schizophrenia. Systematic review and meta-analysis. Eur Child Adolesc Psychiatry 15:141–148PubMedCrossRef Armenteros JL, Davies M (2006) Anti-psychotics in early onset schizophrenia. Systematic review and meta-analysis. Eur Child Adolesc Psychiatry 15:141–148PubMedCrossRef
51.
Zurück zum Zitat Van Os J, Hanssen M, Bijl RV, Volleberg W (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Arch Gen Psychiatry 58:663–668PubMedCrossRef Van Os J, Hanssen M, Bijl RV, Volleberg W (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Arch Gen Psychiatry 58:663–668PubMedCrossRef
52.
Zurück zum Zitat Poulton R, Caspi A, Moffitt TE, Cannon M, Murray RM, Harrington H (2000) Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 57:1053–1058PubMedCrossRef Poulton R, Caspi A, Moffitt TE, Cannon M, Murray RM, Harrington H (2000) Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 57:1053–1058PubMedCrossRef
53.
Zurück zum Zitat Arango C (2011) Attenuated psychotic symptoms syndrome: how it may affect child and adolescent psychiatry. Eur Child Adolesc Psychiatry 20:67–70PubMedCrossRef Arango C (2011) Attenuated psychotic symptoms syndrome: how it may affect child and adolescent psychiatry. Eur Child Adolesc Psychiatry 20:67–70PubMedCrossRef
54.
Zurück zum Zitat Ziermans TB, Schothorst PF, Sprong M, van Engeland H (2001) Transition and remission in adolescents at ultra high-risk for psychosis. Schizophr Res 126(1–3):58–64 Ziermans TB, Schothorst PF, Sprong M, van Engeland H (2001) Transition and remission in adolescents at ultra high-risk for psychosis. Schizophr Res 126(1–3):58–64
Metadaten
Titel
Formal thought disorder in autism spectrum disorder predicts future symptom severity, but not psychosis prodrome
verfasst von
Mart L. J. M. Eussen
Esther I. de Bruin
Arthur R. Van Gool
Anneke Louwerse
Jan van der Ende
Fop Verheij
Frank C. Verhulst
Kirstin Greaves-Lord
Publikationsdatum
01.02.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 2/2015
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-014-0552-9

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