Skip to main content
main-content
Erschienen in: International Urogynecology Journal 6/2022

08.06.2022 | AUGS-IUGA Joint Publication

Foundational science and mechanistic insights for a shared disease model: an expert consensus

Developed by the AUGS Basic Science Subcommittee and IUGA Special Interest Group

verfasst von: Marianna Alperin, Steven Abramowitch, May Alarab, Maria Bortolini, Bryan Brown, Lindsey A. Burnett, Kathleen A. Connell, Margot Damaser, Raffaella de Vita, Caroline E. Gargett, Marsha K. Guess, Zeliha Guler, Renato Natal Jorge, Robert S. Kelley, Mark Kibschull, Kristin Miller, Pamela A. Moalli, Indira U. Mysorekar, Megan R. Routzong, Oksana Shynlova, Carolyn W. Swenson, Marrisa A. Therriault, Gina M. Northington

Erschienen in: International Urogynecology Journal | Ausgabe 6/2022

Einloggen, um Zugang zu erhalten

Excerpt

Pelvic floor disorders (PFDs) are complex conditions that impact millions of women worldwide. It is estimated that PFDs will affect approximately 30%–50%of women older than 50 years and incur a 20% lifetime risk of undergoing at least 1 surgical procedure to repair either pelvic organ prolapse (POP) or stress urinary incontinence (SUI) by age 80 years [ 1]. The surgical costs alone are estimated to exceed $10 billion annually [ 1- 6], and this does not account for the cost of nonsurgical and conservative treatments. Although a large body of epidemiological literature provides important information regarding the risk factors for PFDs, the pathogenesis of POP and SUI continues to be poorly understood. Consequently, POP and SUI are associated with significant health care expenditure primarily due to lack of preventive measures, high failure rate of available interventions, and the need for retreatments. Furthermore, the long-standing gaps in mechanistic insights into the pathophysiology of POP and SUI represent one of the major barriers to the development of scientifically rational preventive and therapeutic strategies. Women's health across the life span depends on a better understanding of the anatomy and physiology of the female pelvic floor (PF) and the causal links between the multifactorial epidemiological risk factors and POP/SUI. …
Literatur
5.
Zurück zum Zitat Subak LL, Waetjen L, Evan den Eeden S. Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol. 2001;98(4):646–51. PubMed Subak LL, Waetjen L, Evan den Eeden S. Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol. 2001;98(4):646–51. PubMed
6.
Zurück zum Zitat Wilson L, Brown JS, Shin GP. Annual direct cost of urinary incontinence. Obstet Gynecol. 2001;98(3):398–406. PubMed Wilson L, Brown JS, Shin GP. Annual direct cost of urinary incontinence. Obstet Gynecol. 2001;98(3):398–406. PubMed
23.
Zurück zum Zitat Committee on Facilitating Interdisciplinary Research, National Academy of Sciences, National Academy of Engineering, Institute of Medicine. Facilitating Interdisciplinary Research. Washington, DC: National Academies Press; 2004. Committee on Facilitating Interdisciplinary Research, National Academy of Sciences, National Academy of Engineering, Institute of Medicine. Facilitating Interdisciplinary Research. Washington, DC: National Academies Press; 2004.
Metadaten
Titel
Foundational science and mechanistic insights for a shared disease model: an expert consensus
Developed by the AUGS Basic Science Subcommittee and IUGA Special Interest Group
verfasst von
Marianna Alperin
Steven Abramowitch
May Alarab
Maria Bortolini
Bryan Brown
Lindsey A. Burnett
Kathleen A. Connell
Margot Damaser
Raffaella de Vita
Caroline E. Gargett
Marsha K. Guess
Zeliha Guler
Renato Natal Jorge
Robert S. Kelley
Mark Kibschull
Kristin Miller
Pamela A. Moalli
Indira U. Mysorekar
Megan R. Routzong
Oksana Shynlova
Carolyn W. Swenson
Marrisa A. Therriault
Gina M. Northington
Publikationsdatum
08.06.2022
Verlag
Springer International Publishing
Erschienen in
International Urogynecology Journal / Ausgabe 6/2022
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-022-05253-y

Weitere Artikel der Ausgabe 6/2022

International Urogynecology Journal 6/2022 Zur Ausgabe

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Gynäkologie und bleiben Sie gut informiert – ganz bequem per eMail.