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01.12.2017 | Research | Ausgabe 1/2017 Open Access

World Journal of Surgical Oncology 1/2017

Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

World Journal of Surgical Oncology > Ausgabe 1/2017
Jiabu Tang, Zheng Yang, Zhuo Wang, Zhen Li, Hongmei Li, Jinbao Yin, Min Deng, Wei Zhu, Chao Zeng



Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer.


In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density.


These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer.


These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer.

Trial registration

Gunagdong Medical University, PJ2013049
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