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Medical Oncology

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01.01.2020 | Review Article

Friend or foe, the role of EGR-1 in cancer

verfasst von: Tong-tong Li, Man-ru Liu, Dong-sheng Pei

Erschienen in: Medical Oncology | Ausgabe 1/2020

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Abstract

Early growth response-1 (EGR-1), also termed NEFI-A and Krox-24, as a multi-domain protein is implicated in several vital physiological processes, including development, metabolism, cell growth and proliferation. Previous studies have implied that EGR-1 was producing in response to the tissue injury, immune response and fibrosis. Meanwhile, emerging studies stressed the pronounced correlation of EGR-1 and human cancers. Nevertheless, the intricate mechanisms of cancer-reduce EGR-1 alteration still poorly characterized. In the review, we evaluated the effects of EGR-1 in tumor cell proliferation, apoptosis, migration, invasion and tumor microenvironment, and then, we dwell on the intricate signaling pathways that EGR-1 involved in. The aberrantly expressed of EGR-1 in cancers are expected to provide a new cancer therapy strategy or a new marker for assessing treatment efficacy.

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Titel: Friend or foe, the role of EGR-1 in cancer
verfasst von: Tong-tong Li
Man-ru Liu
Dong-sheng Pei
Publikationsdatum: 01.01.2020
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 1/2020
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-019-1333-6

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Friend or foe, the role of EGR-1 in cancer

Abstract

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