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Erschienen in: Current Cardiovascular Imaging Reports 2/2015

01.02.2015 | Cardiac Nuclear Imaging (A Cuocolo, Section Editor)

From Physiology of the Coronary Circulation to Myocardial Perfusion Imaging

verfasst von: Henry Gewirtz

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 2/2015

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Abstract

The present paper reviews important recent publications concerning the application of principles of coronary physiology to quantitative PET myocardial perfusion imaging. Invasive measurements as well as coronary computed tomography angiography are also considered. The review focuses on physiological concepts relevant to the understanding of the effects of coronary atherosclerosis on myocardial blood flow (MBF) responses to stress. It also highlights the increasing shift from an anatomical paradigm of stenosis severity assessment to a physiological one, emphasizing the importance of absolute measurements of MBF. Key concepts and supporting literature reviewed in the present paper include quantitative PET measurements of absolute rest and stress MBF, the use of stress MBF alone for physiological assessment of stenosis functional severity, the utility of ratios such as fractional flow reserve (FFR) and coronary flow reserve (CFR) in assessing stenosis severity, and most importantly, the absolute level of MBF required to sustain vigorous physical exercise (9–10 metabolic equivalents (METs)) in healthy adults.
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Metadaten
Titel
From Physiology of the Coronary Circulation to Myocardial Perfusion Imaging
verfasst von
Henry Gewirtz
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 2/2015
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-014-9313-x

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