nach oben

Erschienen in:

09.05.2019 | Clinical Study

Fronto-limbic white matter microstructure, behavior, and emotion regulation in survivors of pediatric brain tumor

verfasst von: Ryan Wier, Holly A. Aleksonis, Matthew M. Pearson, Christopher J. Cannistraci, Adam W. Anderson, John F. Kuttesch Jr., Bruce E. Compas, Kristen R. Hoskinson

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

After treatment, pediatric brain tumor survivors (PBTS) face emotional and behavioral challenges, perhaps due to tumor or treatment-related changes in brain structures involved in emotion regulation, including those with fronto-limbic connections. We hypothesized that relative to healthy controls (HCs), PBTS would exhibit greater difficulties with behavior and emotional functioning, and display reduced mean fractional anisotropy (mFA) in white matter tracts with fronto-limbic connections including the cingulum bundle (CB), inferior fronto-occipital fasciculus (IFOF), and uncinate fasciculus (UF). We further predicted that mFA would account for variance in the relationship between group and emotional/behavioral outcome.

Methods

Eleven 8–16 year old PBTS and 14 HCs underwent MRI, including diffusion tensor imaging to assess white matter microstructure. Tractography quantified mFA of selected tracts. Parents rated children’s emotional and behavioral functioning.

Results

Compared to HCs, caregivers of PBTS reported poorer behavioral regulation and greater internalizing and externalizing symptoms. Relative to HCs, PBTS had lower mFA within the bilateral CB, IFOF, and UF (ds = 0.59–1.15). Across groups, several medium-to-large correlations linked tract mFA and increased internalizing, externalizing, and poor behavioral regulation. Tract mFA also accounted for significant variance in the group-outcome association.

Conclusions

Reduced mFA in fronto-limbic associated tracts may be associated with reduced behavioral regulation following pediatric brain tumor. PBTS with treatment known to impact white matter may be most susceptible. Research with larger, longitudinal samples should clarify this relationship, allow for multiple mediators across time, and consider factors like tumor and treatment type.

Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2017) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014. Neuro Oncol 19(suppl_5):v1–v88CrossRefPubMedPubMedCentral

Surveillance Epidemiology and End Results (SEER) Program (2017) SEER* Stat database: mortality—all COD, aggregated with state, total U.S. (1969–2014). National Cancer Institute, DCCPS, Accessed 14 Jan 2018

Robinson KE, Kuttesch JF, Champion JE, Andreotti CF, Hipp DW, Bettis A, Barnwell A, Compas BE (2010) A quantitative meta-analysis of neurocognitive sequelae in survivors of pediatric brain tumors. Pediatr Blood Cancer 55:525–531. https://doi.org/10.1002/pbc.2256 CrossRefPubMed

De Ruiter MA, Van Mourik R, Schouten-Van Meeteren AYN, Grootenhuis MA, Oosterlaan J (2013) Neurocognitive consequences of a paediatric brain tumour and its treatment: a meta-analysis. Dev Med Child Neurol 55:408–417. https://doi.org/10.1111/dmcn.12020 CrossRefPubMed

Shah SS, Dellarole A, Peterson EC, Bregy A, Komotar R, Harvey PD, Elhammady MS (2015) Long-term psychiatric outcomes in pediatric brain tumor survivors. Child Nerv Syst 31:653–663. https://doi.org/10.1007/s00381-015-2669-7 CrossRef

Upton P, Eiser C (2006) School experiences after treatment for a brain tumour. Child Care Health Dev 32:9–17. https://doi.org/10.1111/1365-2214.2006.00569.x CrossRefPubMed

Poggi G, Liscio M, Galbiati S, Adduci A, Massimino M, Gandola L, Spreafico F, Clerici CA, Fossati-Bellani F, Sommovigo M, Castelli E (2005) Brain tumors in children and adolescents: cognitive and psychological disorders at different ages. Psychooncology 14:386–395. https://doi.org/10.1002/pon.855 CrossRefPubMed

Schultz KAP, Ness KK, Whitton J, Recklitis C, Zebrack B, Robison LL, Zeltzer L, Mertens AC (2007) Behavioral and social outcomes in adolescent survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 25:3649–3656. https://doi.org/10.1200/JCO.2006.09.2486 CrossRefPubMed

Brinkman TM, Palmer SL, Chen S, Zhang H, Evankovich K, Swain MA, Bonner MJ, Janzen L, Knight S, Armstrong CL, Boyle R, Gajjar A (2012) Parent-reported social outcomes after treatment for pediatric embryonal tumors: a prospective longitudinal study. J Clin Oncol 30:4134–4140. https://doi.org/10.1200/JCO.2011.40.6702 CrossRefPubMedPubMedCentral

10.

Sands SA, Pasichow KP, Weiss R, Garvin J, Gardner S, Dunkel IJ, Finlay JL (2011) Long-term follow-up of children treated for high-grade gliomas: Children's Oncology Group L991 final study report. J Neurooncol 30:943–949. https://doi.org/10.1007/s11060-010-0260-3 CrossRef

11.

Barrera M, Schulte F (2009) A group social skills intervention program for survivors of childhood brain tumors. J Pediatr Psychol 34:1108–1118. https://doi.org/10.1093/jpepsy/jsp018 CrossRefPubMed

12.

Barrera M, Schulte F, Spiegler B (2007) Factors influencing depressive symptoms of children treated for brain tumour. J Psychosoc Oncol 26:1–16. https://doi.org/10.1300/J077v26n01_01 CrossRef

13.

de Vries M, de Ruiter MA, Oostrom KJ, Schouten-Van Meeteren AYN, Maurice-Stam H, Oosterlaan J, Grootenhuis MA (2018) The association between the behavior rating inventory of executive functioning and cognitive testing in children diagnosed with a brain tumor. Child Neuropsychol 24:844–858. https://doi.org/10.1080/09297049.2017.1350262 CrossRefPubMed

14.

Batum P, Yagmurlu B (2007) What counts in externalizing behaviors? The contributions of emotion and behavior regulation. Current Psychol Dev Learn Personality Soc 25:272–294. https://doi.org/10.1007/bf02915236 CrossRef

15.

Carpentieri SC, Meyer EA, Delaney BL, Victoria ML, Gannon BK, Doyle JM, Kieran MW (2003) Psychosocial and behavioral functioning among pediatric brain tumor survivors. J Neurooncol 63:279–287. https://doi.org/10.1023/a:1024203323830 CrossRefPubMed

16.

McCandless S, O'Laughlin L (2007) The clinical utility of the Behavior Rating Inventory of Executive Function (BRIEF) in the diagnosis of ADHD. J Atten Disord 10:381–389. https://doi.org/10.1177/1087054706292115 CrossRefPubMed

17.

Diamond A (2013) Executive functions. Annu Rev Psychol 64:135–168. https://doi.org/10.1146/annurevpsych-113011-143750 CrossRefPubMed

18.

Gioia GA, Isquith PK, Guy SC, Kenworthy L (1978) Behavior rating inventory of executive function: professional manual.

19.

Robinson KE, Pearson MM, Cannistraci CJ, Anderson AW, Kuttesch JF, Wymer K, Smith SE, Compas BE (2014) Neuroimaging of executive function in survivors of pediatric brain tumors and healthy controls. Neuropsychology 28:791–800. https://doi.org/10.1037/NEU0000077 CrossRefPubMed

20.

Wolfe KR, Walsh KS, Reynolds NC, Mitchell F, Reddy AT, Paltin I, Madan-Swain A (2013) Executive functions and social skills in survivors of pediatric brain tumor. Child Neuropsychol 19:370–384. https://doi.org/10.1080/09297049.2012.669470 CrossRefPubMed

21.

Mulhern RK, Merchant TE, Gajjar A, Reddick WE, Kun LE (2004) Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol 5:399–408. https://doi.org/10.1016/S1470-2045(04)01507-4 CrossRefPubMed

22.

Reddick WE, White HA, Glass JO, Wheeler GC, Thompson SJ, Gajjar A, Leigh L, Mulhern RK (2003) Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer 97:2512–2519. https://doi.org/10.1002/cncr.11355 CrossRefPubMed

23.

Beaulieu C (2002) The basis of anisotropic water diffusion in the nervous system—a technical review. NMR Biomed 15:435–455. https://doi.org/10.1002/nbm.782 CrossRefPubMed

24.

Palmer SL (2008) Neurodevelopmental impact on children treated for medulloblastoma: a review and proposed conceptual model. Dev Disabil Res Rev 14:203–210. https://doi.org/10.1002/ddrr.32 CrossRefPubMedPubMedCentral

25.

Hoang DH, Pagnier A, Guichardet K, Dubois-Teklali F, Schiff I, Lyard G, Cousin E, Krainik A (2014) Cognitive disorders in pediatric medulloblastoma: what neuroimaging has to offer. J Neurosurg Pediatr 14:136–144. https://doi.org/10.3171/2014.5.peds13571 CrossRefPubMed

26.

Palmer SL, Glass JO, Li Y, Ogg R, Qaddoumi I, Armstrong GT, Wright K, Wetmore C, Broniscer A, Gajjar A, Reddick WE (2012) White matter integrity is associated with cognitive processing in patients treated for a posterior fossa brain tumor. Neurooncology 14:1185–1193. https://doi.org/10.1093/neuonc/nos154 CrossRef

27.

Tekin S, Cummings JL (2002) Frontal–subcortical neuronal circuits and clinical neuropsychiatry. J Psychosomat Res 53:647–654. https://doi.org/10.1016/S0022-3999(02)00428-2 CrossRef

28.

Blood AJ, Iosifescu DV, Makris N, Perlis RH, Kennedy DN, Dougherty DD, Kim BW, Lee MJ, Wu S, Lee S, Calhoun J, Hodge SM, Fava M, Rosen BR, Smoller JW, Gasic GP, Breiter HC for the Phenotype Genotype Project on Addiction and Mood Disorders (2010) Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder. PLoS ONE 5:e13945. https://doi.org/10.1371/journal.pone.0013945 CrossRef

29.

LeWinn KZ, Connolly CG, Wu J, Drahos M, Hoeft F, Ho TC, Simmons AN, Yang TT (2014) White matter correlates of adolescent depression: Structural evidence for frontolimbic disconnectivity. J Am Acad Child Adolesc Psychiatry 53:899–909. https://doi.org/10.1016/j.jaac.2014.04.021 CrossRefPubMedPubMedCentral

30.

Zhu X, Wang X, Xiao J, Zhong M, Liao J, Yao S (2011) Altered white matter integrity in first-episode, treatment-naive young adults with major depressive disorder: a tract-based spatial statistics study. Brain Res 1369:223–229. https://doi.org/10.1016/j.brainres.2010.10.104 CrossRefPubMed

31.

Zou K, Huang X, Li T, Gong Q, Li Z, Ou-yang L, Deng W, Chen Q, Li C, Ding Y, Sun X (2008) Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study. J Psychiatry Neurosci 33:525–530PubMedPubMedCentral

32.

Mincic AM (2015) Neuroanatomical correlates of negative emotionality-related traits: a systematic review and meta-analysis. Neuropsychologia 77:97–118. https://doi.org/10.1016/j.neuropsychologia.2015.08.007 CrossRefPubMed

33.

Cullen KR, Klimes-Dougan B, Muetzel R, Mueller BA, Camchong J, Houri A, Kurma S, Lim KO (2010) Altered white matter microstructure in adolescents with major depression: a preliminary study. J Am Acad Child Adolesc Psychiatry 49:173–183. https://doi.org/10.1016/j.jaac.2009.11.005 CrossRefPubMedPubMedCentral

34.

Ho TC, King LS, Leong JK, Colich NL, Humphreys KL, Ordaz SJ, Gotlib IH (2017) Effects of sensitivity to life stress on uncinate fasciculus segments in early adolescence. Soc Cog Affect Neurosci 12:1460–1469. https://doi.org/10.1093/scan/nsx065 CrossRef

35.

Richter A, Woernle CM, Krayenbuhl N, Kollias S, Bellut D (2015) Affective symptoms and white matter changes in brain tumor patients. World Neurosurg 84:927–932. https://doi.org/10.1016/j.wneu.2015.05.031 CrossRefPubMed

36.

Achenbach TM, Rescoria LA (2001) Manual for the ASEBA school-age forms & profiles. University of Vermont, Research Center for Children, Youth, & Families, Burlington, VT

37.

Yeh FC, Verstynen TD, Wang Y, Fernandez-Miranda JC, Tseng WYI (2013) Deterministic diffusion fiber tracking improved by quantitative anisotropy. PLoS ONE 8:e80713. https://doi.org/10.1371/jounral.pone.0080713 CrossRefPubMedPubMedCentral

38.

Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Earlbaum Associates, Hillsdale, NJ

39.

Fisher RA (1921) On the probable error of a coefficient of correlation deduced from a small sample. Metron 1:3–32

40.

Hayes AF (2012) PROCESS: a versatile computational tool for observed variable mediation, moderation, and conditional process modeling. [White paper].

41.

Deegan J (1978) On the occurrence of standardized regression coefficients greater than one. Educ Psychol Meas 38:873–888. https://doi.org/10.1177/001316447803800404 CrossRef

42.

Robinson KE, Pearson MM, Cannistraci CJ, Anderson AW, Kuttesch JF Jr, Wymer K, Smith SE, Park S, Compas BE (2015) Functional neuroimaging of working memory in survivors of childhood brain tumors and healthy children: associations with coping and psychosocial outcomes. Child Neuropsychol 21:779–802. https://doi.org/10.1080/09297049.2014.924492 CrossRefPubMed

43.

Deoni SCL, Dean DC, O’Muircheartaigh J, Dirks H, Jerskey BA (2012) Investigating white matter development in infancy and early childhood using myelin water faction and relaxation time mapping. NeuroImage 63:1038–1053. https://doi.org/10.1016/j.neuroimage.2012.07.037 CrossRefPubMedPubMedCentral

44.

Madsen KS, Jernigan TL, Iversen P, Frokjaer VG, Mortensen EL, Knudsen GM, Baare WFC (2012) Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. Psychiatry Res Neuroimaging 201:63–72. https://doi.org/10.1016/j.psycchresns.2011.07.015 CrossRef

45.

Shankman SA, Tenke CE, Bruder GE, Durbin CE, Hayden EP, Klein DN (2005) Low positive emotionality in young children: association with EEG asymmetry. Dev Psychopathol 17:85–98. https://doi.org/10.1017/S0954579405050054 CrossRefPubMed

46.

Johnstone T, van Reekum CM, Urry HL, Kalin NH, Davidson RJ (2007) Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. J Neurosci 27:8877–8884. https://doi.org/10.1523/jneurosci.2063-07.2007 CrossRefPubMedPubMedCentral

47.

Eden AS, Schreiber J, Anwander A, Keuper K, Laeger I, Zwanzger P, Zwitserlood P, Kugel H, Dobel C (2015) Emotion regulation and trait anxiety are predicted by the microstructure of fibers between amygdala and prefrontal cortex. J Neurosci 35:6020–6027. https://doi.org/10.1523/jneurosci.3659-14.2015 CrossRefPubMedPubMedCentral

Titel: Fronto-limbic white matter microstructure, behavior, and emotion regulation in survivors of pediatric brain tumor
verfasst von: Ryan Wier
Holly A. Aleksonis
Matthew M. Pearson
Christopher J. Cannistraci
Adam W. Anderson
John F. Kuttesch Jr.
Bruce E. Compas
Kristen R. Hoskinson
Publikationsdatum: 09.05.2019
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2019
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03180-5

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

23.04.2024 | Demenz | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Fronto-limbic white matter microstructure, behavior, and emotion regulation in survivors of pediatric brain tumor

Abstract

Purpose

Methods

Results

Conclusions

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2019

Spinal location is prognostic of survival for solitary-fibrous tumor/hemangiopericytoma of the central nervous system

Rescue bevacizumab following symptomatic pseudoprogression of a tectal glioma post-radiotherapy: a case report and review of the literature

Gliosarcoma: distinct molecular pathways and genomic alterations identified by DNA copy number/SNP microarray analysis

Contrast-enhancement in supratentorial low-grade gliomas: a classic prognostic factor in the molecular age

Comparative analysis of intracranial meningiomas in patients younger than 40 years

Association of MRI findings with clinical characteristics and prognosis in patients with leptomeningeal carcinomatosis from non-small cell lung cancer

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie