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Erschienen in: European Journal of Pediatrics 9/2019

19.07.2019 | Original Article

Fructose malabsorption in asymptomatic children and in patients with functional chronic abdominal pain: a prospective comparative study

verfasst von: Oihana Martínez-Azcona, Ana Moreno-Álvarez, Teresa Seoane-Pillado, Inés Niño-Grueiro, Ana Ramiro-Comesaña, María Menéndez-Riera, Marta Pérez-Domínguez, Alfonso Solar-Boga, Rosaura Leis-Trabazo

Erschienen in: European Journal of Pediatrics | Ausgabe 9/2019

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Abstract

The objective of this prospective cohort study was to compare fructose malabsorption in patients with functional chronic abdominal pain and in healthy children. The sample was divided into two groups: asymptomatic children and pain-predominant functional gastrointestinal disorders according to the Rome IV criteria. All children were tested for fructose malabsorption by a standardized breath hydrogen test. Hydrogen and methane were measured and the test was presumed positive when it exceeded 20 ppm above baseline. If positive, patients were given a low-fructose diet and the response was evaluated. One hundred five children were included (34 healthy children, 71 with functional chronic abdominal pain), with similar demographic characteristics in both groups (35.2% male, age 9.5 ± 2.8 years). Hydrogen levels in breath were tested through a hydrogen test for fructose demonstrating malabsorption in 58.8% of healthy children (95%CI 40.8%–76.8%) and in 40.8% of children with chronic abdominal pain (95%CI 28.7%–53.0%), removing those who had bacterial overgrowth. Twenty-one of 31 patients with symptoms and a positive test (72.4%) reported an improvement on a low-fructose diet.
Conclusion: Fructose malabsorption is more common in asymptomatic children than in patients with chronic abdominal pain. Better standardized test conditions are necessary to improve accuracy of diagnosis before using this test in clinical practice.
What is Known:
Although fructose malabsorption is believed to be related with chronic abdominal pain, high-quality evidence is lacking.
Concerns have raised regarding the use of breath hydrogen test for fructose malabsorption in children with chronic abdominal pain.
What is New:
Fructose malabsorption is not more common in children with pain-predominant functional gastrointestinal disorders than in asymptomatic children.
Improvement in symptoms with low-fructose diet may indicate that, although patients with pain-predominant functional gastrointestinal disorders did not have a higher percentage of malabsorption, they had greater fructose intolerance.
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Metadaten
Titel
Fructose malabsorption in asymptomatic children and in patients with functional chronic abdominal pain: a prospective comparative study
verfasst von
Oihana Martínez-Azcona
Ana Moreno-Álvarez
Teresa Seoane-Pillado
Inés Niño-Grueiro
Ana Ramiro-Comesaña
María Menéndez-Riera
Marta Pérez-Domínguez
Alfonso Solar-Boga
Rosaura Leis-Trabazo
Publikationsdatum
19.07.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Pediatrics / Ausgabe 9/2019
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-019-03418-4

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