Erschienen in:
01.11.2006 | Poster Presentation
Functional analysis of altered Tenascin isoform expression in breast cancer
verfasst von:
RA Alcock, JH Pringle, JA Shaw, DL Holliday, M Allen, RA Walker, JL Jones
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2006
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Excerpt
Cellular interactions with the extracellular matrix (ECM) control many aspects of cell function. The complex ECM protein Tenascin-C (TN), which exists as multiple isoforms, is upregulated in breast cancer. We previously have identified a change in the TN isoform profile in breast cancer, with detection of two additional isoforms — TN16 and TN14/16 — not seen in normal breast [
1]. The purpose of this study was to investigate directly the effects of these tumour-associated TNC isoforms on breast cancer cell behaviour. …