Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia
- 10.02.2025
- Research
Erschienen in:
- Verfasst von
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Yichen Song
Yichen Song
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Yichen Song and HanYu Zhu contributed equally to this work.
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
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HanYu Zhu
HanYu Zhu
-
Yichen Song and HanYu Zhu contributed equally to this work.
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
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Zhaoyang Wu
Zhaoyang Wu
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
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Wenyan Hu
Wenyan Hu
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
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Sen Zhang
Sen Zhang
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
- Brain Institute, Henan Academy of Innovations in Medical Science, 453002, Xinxiang, China
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Youqi Zhou
Youqi Zhou
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
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Yue Peng
Yue Peng
- The Fifth Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China
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Yongfeng Yang
Yongfeng Yang
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
- Brain Institute, Henan Academy of Innovations in Medical Science, 453002, Xinxiang, China
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Wenqiang Li
Wenqiang Li
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
- Brain Institute, Henan Academy of Innovations in Medical Science, 453002, Xinxiang, China
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Han Shi
Han Shi
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
- Brain Institute, Henan Academy of Innovations in Medical Science, 453002, Xinxiang, China
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Ge Yang
Ge Yang
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Brain Institute, Henan Academy of Innovations in Medical Science, 453002, Xinxiang, China
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Yan Zhang
Korrespondierender Autor Yan Zhang
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
- Brain Institute, Henan Academy of Innovations in Medical Science, 453002, Xinxiang, China
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Luxian Lv
Korrespondierender Autor Luxian Lv
- Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, 453002, Xinxiang, China
- International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, 453002, Xinxiang, China
- Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, 453002, Xinxiang, China
- Xinxiang Key Laboratory of Child and Adolescent Psychiatry, 453002, Xinxiang, China
- Brain Institute, Henan Academy of Innovations in Medical Science, 453002, Xinxiang, China
- Erschienen in
- European Child & Adolescent Psychiatry | Ausgabe 8/2025
Abstract
Background
The role of functional connectivity (FC) changes in the prefrontal-thalamic-cerebellar circuit in schizophrenia has received widespread attention. Currently, domestic and international studies on this circuit have focused on adults, while the FC of this circuit in the brains of adolescent patients with schizophrenia (AOS) has been less reported.
Methods
We recruited 124 subjects who underwent resting-state functional magnetic resonance imaging scans at baseline, using key brain regions in the prefrontal-thalamic-cerebellar circuit as seed regions, to investigate the FC in AOS versus healthy controls. The FC of this loop was compared with that of the whole brain in healthy controls.
Results
Compared to healthy controls, patients with AOS had reduced FC between the medial prefrontal cortex (mPFC) and precuneus (PCu) and between the posterior cerebellar lobe and middle temporal gyrus. Reduced FC between the left mPFC and the left PCu in patients with AOS was associated with positive symptom scores on the PANSS and was positively correlated with the Symbolic Encoding Scale, the Maze Scale, and the Category Fluency Test Scale. Reduced FC between the right posterior cerebellar lobe and the right middle temporal gyrus is positively correlated with the simple visuospatial memory test in AOS patients.
Conclusions
There are FC abnormalities in the prefrontal-thalamic-cerebellar circuit, precuneus, and temporal lobe in AOS. These abnormalities appear in the early stages of schizophrenia, independent of medication, and are characteristic of the disorder.
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- Titel
- Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia
- Verfasst von
-
Yichen Song
HanYu Zhu
Zhaoyang Wu
Wenyan Hu
Sen Zhang
Youqi Zhou
Yue Peng
Yongfeng Yang
Wenqiang Li
Han Shi
Ge Yang
Yan Zhang
Luxian Lv
- Publikationsdatum
- 10.02.2025
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
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European Child & Adolescent Psychiatry / Ausgabe 8/2025
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X - DOI
- https://doi.org/10.1007/s00787-025-02656-2
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