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Erschienen in: Neuropsychology Review 2/2016

08.07.2016 | Review

Functional Disability in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

verfasst von: Cutter A. Lindbergh, Rodney K. Dishman, L. Stephen Miller

Erschienen in: Neuropsychology Review | Ausgabe 2/2016

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Abstract

Accumulating evidence suggests that the pre-dementia syndrome mild cognitive impairment (MCI) is characterized by decrements in instrumental activities of daily living (IADL). The current review was a quantitative synthesis of the available literature to objectively characterize IADL disability in MCI while clarifying inconsistencies in findings across studies. It was hypothesized that individuals with MCI would display significantly greater functional impairment relative to cognitively intact controls. Candidate moderators specified a priori included functional assessment approach, MCI subtype, depressive symptoms, and language conducted. Online databases (PubMed/MEDLINE and PsycINFO) and reference lists were searched to identify peer-reviewed publications assessing IADL in MCI compared to normal aging. A total of 151 effect sizes derived from 106 studies met inclusionary criteria (N = 62,260). Random effects models yielded a large overall summary effect size (Hedges’ g = 0.76, 95 % confidence interval: 0.68 − 0.83, p < .001) confirmed in multi-level analyses adjusted for nesting of effect sizes within studies (g = 0.78, 95 % confidence interval: 0.69 − 0.87). Functional assessment strategy and MCI subtype were significant moderators of effect size, whereas depressive symptoms and language were not. Results convincingly demonstrate that MCI is associated with significant difficulties in the performance of complex everyday tasks. It appears that functional decline, like cognitive decline, exists on a continuum from healthy aging to dementia onset. Implications for clinical practice and research priorities are discussed.
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Metadaten
Titel
Functional Disability in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
verfasst von
Cutter A. Lindbergh
Rodney K. Dishman
L. Stephen Miller
Publikationsdatum
08.07.2016
Verlag
Springer US
Erschienen in
Neuropsychology Review / Ausgabe 2/2016
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI
https://doi.org/10.1007/s11065-016-9321-5

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