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01.01.2012 | Chest

Functional imaging of lung cancer using dual energy CT: how does iodine related attenuation correlate with standardized uptake value of 18FDG-PET-CT?

verfasst von: G. Schmid-Bindert, Thomas Henzler, T. Q. Chu, M. Meyer, J. W. Nance Jr, U. J. Schoepf, D. J. Dinter, P. Apfaltrer, R. Krissak, C. Manegold, S. O. Schoenberg, C. Fink

Erschienen in: European Radiology | Ausgabe 1/2012

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Abstract

Objectives

To investigate the correlation between maximum standardized uptake value (SUV_max) of ¹⁸FDG PET-CT and iodine-related attenuation (IRA) of dual energy CT (DECT) of primary tumours and ¹⁸FDG PET-CT positive thoracic lymph nodes (LN) in patients with lung cancer.

Methods

37 patients with lung cancer (27 NSCLC, 10 SCLC, 86 ¹⁸FDG PET-CT positive thoracic LN) who underwent both ¹⁸FDG PET-CT and DECT were analyzed. The mean study interval between ¹⁸FDG PET-CT and DECT was ≤21 days in 17 patients. The mean and maximum IRA of DECT as well as of virtual unenhanced and virtual 120 kV images of DECT was analyzed and correlated to the SUV_max of ¹⁸FDG PET-CT in all tumours and ¹⁸FDG PET-CT positive thoracic lymph nodes. Further subgroup analysis was performed for histological subtypes in all groups.

Results

A moderate correlation was found between SUV_max and maximum IRA in all tumours (n = 37;r = 0.507;p = 0.025) whereas only weak or no correlation were found between SUV_max and all other DECT measurements. A strong correlation was found in patients with study intervals ≤21 days (n = 17; r = 0.768;p = 0.017). Analysis of histological subtypes of lung cancer showed a strong correlation between SUV_max and maximum IRA in the analysis of all patients with NSCLC (r = 0.785;p = 0.001) and in patients with NSCLC and study intervals ≤21 days (r = 0.876;p = 0.024).

Thoracic LN showed moderate correlation between SUV_max and maximum IRA in patients with study intervals ≤21 days (r = 0.654; p = 0.010) whereas a weak correlation was found between SUV_max and maximum IRA in patients with study intervals >21 days (r = 0.299; p = 0.035).

Conclusions

DECT could serve as a valuable functional imaging test for patients with NSCLC as the IRA of DECT correlates with SUV_max of ¹⁸FDG PET-CT.

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Titel: Functional imaging of lung cancer using dual energy CT: how does iodine related attenuation correlate with standardized uptake value of 18FDG-PET-CT?
verfasst von: G. Schmid-Bindert
Thomas Henzler
T. Q. Chu
M. Meyer
J. W. Nance Jr
U. J. Schoepf
D. J. Dinter
P. Apfaltrer
R. Krissak
C. Manegold
S. O. Schoenberg
C. Fink
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 1/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2230-3

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Functional imaging of lung cancer using dual energy CT: how does iodine related attenuation correlate with standardized uptake value of 18FDG-PET-CT?

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Objectives

Methods

Results

Conclusions

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