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Erschienen in: Documenta Ophthalmologica 1/2010

01.08.2010 | Original research article

Functional involvement of cone photoreceptors in advanced glaucoma: a multifocal electroretinogram study

verfasst von: Ajoy Vincent, Rohit Shetty, Sathi A. V. Devi, Mathew K. Kurian, Ramgopal Balu, Bhujang Shetty

Erschienen in: Documenta Ophthalmologica | Ausgabe 1/2010

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Abstract

The purpose of the study is (1) to demonstrate the anatomical variation of cone photoreceptor density across normal retina as a sectoral amplitude asymmetry of photopic multifocal electroretinogram (mfERG) and (2) to study the potential presence of sequential or differential, functional cone photoreceptor damage in glaucoma using this amplitude asymmetry. A 37-Block scaled mfERG was recorded from 22 controls and 27 glaucoma subjects. The N1 and P1 amplitudes of averaged responses from corresponding zones nasal and temporal to fovea were analyzed for asymmetry in controls and glaucoma subjects. Amplitude asymmetry was demonstrable for both N1 (p < 0.001) and P1 (p < 0.001) parameters in control subjects. Although this amplitude asymmetry was preserved in glaucoma subjects with moderate field defects, it was not demonstrable in patients with advanced field defects. The anatomical variation in cone photoreceptor distribution across normal retina is demonstrated as an amplitude asymmetry in first order kernel responses of mfERG. The cone photoreceptors in the region nasal to fovea appear to be affected only in advanced glaucoma possibly suggesting that photoreceptors could follow a sequential damage like the overlying neuroretinal rim in glaucoma.
Literatur
1.
Zurück zum Zitat Sutter EE (1991) The fast m-transform: a fast computation of cross-correlations with binary m-sequences. Soc Ind Appl Math 20:686–694 Sutter EE (1991) The fast m-transform: a fast computation of cross-correlations with binary m-sequences. Soc Ind Appl Math 20:686–694
2.
Zurück zum Zitat Sutter EE, Tran D (1992) The field topography of ERG components in man, I: the photopic luminance response. Vis Res 32:433–466CrossRefPubMed Sutter EE, Tran D (1992) The field topography of ERG components in man, I: the photopic luminance response. Vis Res 32:433–466CrossRefPubMed
3.
Zurück zum Zitat Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Palmowski-Wolfe AM (2008) ISCEV guidelines for clinical multifocal electroretinography (2007 edition). Doc Ophthalmol 116:1–11CrossRefPubMed Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Palmowski-Wolfe AM (2008) ISCEV guidelines for clinical multifocal electroretinography (2007 edition). Doc Ophthalmol 116:1–11CrossRefPubMed
4.
Zurück zum Zitat Hood DC, Frishman LJ, Saszik S, Viswanathan S (2002) Retinal origins of the primate multifocal ERG: implications for the human response. Invest Ophthalmol Vis Sci 43(5):1673–1685PubMed Hood DC, Frishman LJ, Saszik S, Viswanathan S (2002) Retinal origins of the primate multifocal ERG: implications for the human response. Invest Ophthalmol Vis Sci 43(5):1673–1685PubMed
5.
Zurück zum Zitat Jonas JB, Schneider U, Naumann GO (1992) Count and density of human retinal photoreceptors. Graefes Arch Clin Exp Ophthalmol 230(6):505–510CrossRefPubMed Jonas JB, Schneider U, Naumann GO (1992) Count and density of human retinal photoreceptors. Graefes Arch Clin Exp Ophthalmol 230(6):505–510CrossRefPubMed
6.
Zurück zum Zitat Curcio CA, Sloan KR, Kalina RE, Hendrickson AE (1990) Human photoreceptor topography. J Comp Neurol 292(4):497–523CrossRefPubMed Curcio CA, Sloan KR, Kalina RE, Hendrickson AE (1990) Human photoreceptor topography. J Comp Neurol 292(4):497–523CrossRefPubMed
7.
Zurück zum Zitat Hitchings RA, Wheeler CA (1980) The optic disk in glaucoma (IV. Optic disc evaluation in the ocular hypertensive patient). Br J Ophthalmol 64:232–239CrossRefPubMed Hitchings RA, Wheeler CA (1980) The optic disk in glaucoma (IV. Optic disc evaluation in the ocular hypertensive patient). Br J Ophthalmol 64:232–239CrossRefPubMed
8.
Zurück zum Zitat Hitchings RA (1978) The optic disk in glaucoma (III. Diffuse optic disk pallor with raised intraocular pressure). Br J Ophthalmol 62:670–675CrossRefPubMed Hitchings RA (1978) The optic disk in glaucoma (III. Diffuse optic disk pallor with raised intraocular pressure). Br J Ophthalmol 62:670–675CrossRefPubMed
9.
Zurück zum Zitat Hitchings RA, Spaeth GL (1977) The optic disk in glaucoma (II. Correlation of the appearance of the optic disc with the visual field). Br J Ophthalmol 61:107–113CrossRefPubMed Hitchings RA, Spaeth GL (1977) The optic disk in glaucoma (II. Correlation of the appearance of the optic disc with the visual field). Br J Ophthalmol 61:107–113CrossRefPubMed
10.
Zurück zum Zitat Jonas JB, Fernández M, Stürmer J (1993) Pattern of glaucomatous neuroretinal rim loss. Ophthalmology 100:63–67PubMed Jonas JB, Fernández M, Stürmer J (1993) Pattern of glaucomatous neuroretinal rim loss. Ophthalmology 100:63–67PubMed
11.
Zurück zum Zitat Kirsch RE, Anderson DR (1973) Clinical recognition of glaucomatous cupping. Am J Ophthalmol 75:442–454PubMed Kirsch RE, Anderson DR (1973) Clinical recognition of glaucomatous cupping. Am J Ophthalmol 75:442–454PubMed
12.
Zurück zum Zitat Pederson JE, Anderson DR (1980) The mode of progressive disc cupping in ocular hypertension and glaucoma. Arch Ophthalmol 98:490–495PubMed Pederson JE, Anderson DR (1980) The mode of progressive disc cupping in ocular hypertension and glaucoma. Arch Ophthalmol 98:490–495PubMed
13.
Zurück zum Zitat Tuulonen A, Airaksinen PJ (1991) Initial glaucomatous optic disk and retinal nerve fiber layer abnormalities and the mode of their progression. Am J Ophthalmol 111:485–490PubMed Tuulonen A, Airaksinen PJ (1991) Initial glaucomatous optic disk and retinal nerve fiber layer abnormalities and the mode of their progression. Am J Ophthalmol 111:485–490PubMed
14.
Zurück zum Zitat Kendell KR, Quigley HA, Kerrigan LA, Pease ME, Quigley EN (1995) Primary open angle glaucoma is not associated with photoreceptor loss. Invest Ophthalmol Vis Sci 36:200–205PubMed Kendell KR, Quigley HA, Kerrigan LA, Pease ME, Quigley EN (1995) Primary open angle glaucoma is not associated with photoreceptor loss. Invest Ophthalmol Vis Sci 36:200–205PubMed
15.
Zurück zum Zitat Panda S, Jonas JB (1992) Decreased photoreceptor count in human eyes with secondary angle closure glaucoma. Invest Ophthalmol Vis Sci. 33:2532–2536PubMed Panda S, Jonas JB (1992) Decreased photoreceptor count in human eyes with secondary angle closure glaucoma. Invest Ophthalmol Vis Sci. 33:2532–2536PubMed
16.
Zurück zum Zitat Hodapp E, Parrish RK, Anderson DR (1993) Clinical decisions in glaucoma. The CV: Mosby Co, St. Louis, pp 52–61 Hodapp E, Parrish RK, Anderson DR (1993) Clinical decisions in glaucoma. The CV: Mosby Co, St. Louis, pp 52–61
17.
Zurück zum Zitat Wilker KC, Williams RW, Rakic P (1990) Photoreceptor mosaic: number and distribution of cones and rods in rhesus monkey retina. J Comp Neurol 297:499–508CrossRef Wilker KC, Williams RW, Rakic P (1990) Photoreceptor mosaic: number and distribution of cones and rods in rhesus monkey retina. J Comp Neurol 297:499–508CrossRef
18.
Zurück zum Zitat Curcio CA, Millican CL, Allen KA, Kalina RE (1993) Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci 34:3278–3296PubMed Curcio CA, Millican CL, Allen KA, Kalina RE (1993) Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci 34:3278–3296PubMed
19.
Zurück zum Zitat Hood DC, Frishman LJ, Viswanathan S, Robson JG, Ahmed J (1999) Evidence for a substantial ganglion cell contribution to the primate electroretinogram (ERG): effect of TTX on the multifocal ERG in macaque. Vis Neurosci 16(3):411–416CrossRefPubMed Hood DC, Frishman LJ, Viswanathan S, Robson JG, Ahmed J (1999) Evidence for a substantial ganglion cell contribution to the primate electroretinogram (ERG): effect of TTX on the multifocal ERG in macaque. Vis Neurosci 16(3):411–416CrossRefPubMed
20.
Zurück zum Zitat Hood DC, Greenstein V, Frishman LJ, Holopigian K, Viswanathan S, Seiple W, Ahmed J, Robson JG (1999) Identifying inner retinal contributions to the human multifocal ERG. Vis Res 39:2285–2291CrossRefPubMed Hood DC, Greenstein V, Frishman LJ, Holopigian K, Viswanathan S, Seiple W, Ahmed J, Robson JG (1999) Identifying inner retinal contributions to the human multifocal ERG. Vis Res 39:2285–2291CrossRefPubMed
21.
22.
Zurück zum Zitat Bearse MA, Sutter EE (1998) Contrast dependence of multifocal ERG components. Visual science and its application, OSA Technical Digest Series 24–27 Bearse MA, Sutter EE (1998) Contrast dependence of multifocal ERG components. Visual science and its application, OSA Technical Digest Series 24–27
23.
Zurück zum Zitat Jonas JB, Gusek GC, Naumann GOH (1988) Optic disc, cup and neuroretinal rim size, configuration, and correlations in normal eyes. Invest Ophthalmol Vis Sci 29:1151–1158PubMed Jonas JB, Gusek GC, Naumann GOH (1988) Optic disc, cup and neuroretinal rim size, configuration, and correlations in normal eyes. Invest Ophthalmol Vis Sci 29:1151–1158PubMed
24.
Zurück zum Zitat DeLeón-Ortega JE, Arthur SN, McGwin G, Xie A, Monheit BE, Girkin CA (2006) Discrimination between glaucomatous and nonglaucomatous eyes using quantitative imaging devices and subjective optic nerve head assessment. Invest Ophthalmol Vis Sci 47:3374–3380CrossRefPubMed DeLeón-Ortega JE, Arthur SN, McGwin G, Xie A, Monheit BE, Girkin CA (2006) Discrimination between glaucomatous and nonglaucomatous eyes using quantitative imaging devices and subjective optic nerve head assessment. Invest Ophthalmol Vis Sci 47:3374–3380CrossRefPubMed
25.
Zurück zum Zitat Quigley HA, Addicks EM, Green WR, Maumenee AE (1982) Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischaemic optic neuropathy, papilledema and toxic neuropathy. Arch Ophthalmol 100:135–146PubMed Quigley HA, Addicks EM, Green WR, Maumenee AE (1982) Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischaemic optic neuropathy, papilledema and toxic neuropathy. Arch Ophthalmol 100:135–146PubMed
26.
Zurück zum Zitat Karlberg B, Hedin A, Bjornberg K (1968) Electroretinography during short-term intraocular tension rise. Acta Ophthalmol 46:742–747CrossRef Karlberg B, Hedin A, Bjornberg K (1968) Electroretinography during short-term intraocular tension rise. Acta Ophthalmol 46:742–747CrossRef
27.
Zurück zum Zitat Alvis DL (1966) Electroretinographic changes in controlled chronic open angle glaucoma. Am J Ophthalmol 61:121–131PubMed Alvis DL (1966) Electroretinographic changes in controlled chronic open angle glaucoma. Am J Ophthalmol 61:121–131PubMed
28.
Zurück zum Zitat Bartl G, Benedikt O, Hiti H (1978) The effect of elevated intraocular pressure on the human ERG and VER. Graefes Arch Clin Exp Ophthalmol 207:275–279CrossRef Bartl G, Benedikt O, Hiti H (1978) The effect of elevated intraocular pressure on the human ERG and VER. Graefes Arch Clin Exp Ophthalmol 207:275–279CrossRef
29.
Zurück zum Zitat Fazio DT, Heckenlively JR, Martin DA, Christensen RE (1986) The Electroretinogram in advanced open angle glaucoma. Doc Ophthalmol 63:45–54CrossRefPubMed Fazio DT, Heckenlively JR, Martin DA, Christensen RE (1986) The Electroretinogram in advanced open angle glaucoma. Doc Ophthalmol 63:45–54CrossRefPubMed
30.
Zurück zum Zitat Velton IM, Korth M, Horn FK (2001) The a-wave of the dark-adapted Electroretinogram in glaucomas: are photoreceptors affected? Br J Ophthalmol 85:397–402CrossRef Velton IM, Korth M, Horn FK (2001) The a-wave of the dark-adapted Electroretinogram in glaucomas: are photoreceptors affected? Br J Ophthalmol 85:397–402CrossRef
31.
Zurück zum Zitat Velton IM, Horn FK, Korth M, Velten K (2001) The b-wave of the dark-adapted Electroretinogram in patients with advanced asymmetrical glaucoma and normal subjects. Br J Ophthalmol 85:403–409CrossRef Velton IM, Horn FK, Korth M, Velten K (2001) The b-wave of the dark-adapted Electroretinogram in patients with advanced asymmetrical glaucoma and normal subjects. Br J Ophthalmol 85:403–409CrossRef
32.
Zurück zum Zitat Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith EL (1999) The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci 40:1124–1136PubMed Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith EL (1999) The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci 40:1124–1136PubMed
33.
Zurück zum Zitat Hood DC, Greenstein VC, Holopigian K, Bauer R, Firoz B, Liebmann JM, Odel JG, Ritch R (2000) An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG. Invest Ophthalmol Vis Sci 41:1570–1579PubMed Hood DC, Greenstein VC, Holopigian K, Bauer R, Firoz B, Liebmann JM, Odel JG, Ritch R (2000) An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG. Invest Ophthalmol Vis Sci 41:1570–1579PubMed
34.
Zurück zum Zitat Hasegawa S, Takagi M, Usui T, Takada R, Abe H (2000) Waveform changes of the first order multifocal electroretinogram in patients with glaucoma. Invest Ophthalmol Vis Sci 41:1597–1603PubMed Hasegawa S, Takagi M, Usui T, Takada R, Abe H (2000) Waveform changes of the first order multifocal electroretinogram in patients with glaucoma. Invest Ophthalmol Vis Sci 41:1597–1603PubMed
35.
Zurück zum Zitat Klistorner A, Graham SL, Martins A (2000) Multifocal pattern electroretinogram does not demonstrate localized field defects in glaucoma. Doc Ophthalmol 100:155–165CrossRef Klistorner A, Graham SL, Martins A (2000) Multifocal pattern electroretinogram does not demonstrate localized field defects in glaucoma. Doc Ophthalmol 100:155–165CrossRef
Metadaten
Titel
Functional involvement of cone photoreceptors in advanced glaucoma: a multifocal electroretinogram study
verfasst von
Ajoy Vincent
Rohit Shetty
Sathi A. V. Devi
Mathew K. Kurian
Ramgopal Balu
Bhujang Shetty
Publikationsdatum
01.08.2010
Verlag
Springer-Verlag
Erschienen in
Documenta Ophthalmologica / Ausgabe 1/2010
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-010-9227-0

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