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European Radiology

Erschienen in:

14.01.2022 | Neuro

Functional MRI evidence for primary motor cortex plasticity contributes to the disease’s severity and prognosis of cervical spondylotic myelopathy patients

verfasst von: Rui Zhao, Xing Guo, Yang Wang, YingChao Song, Qian Su, HaoRan Sun, Meng Liang, Yuan Xue

Erschienen in: European Radiology | Ausgabe 6/2022

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Abstract

Objective

To investigate the brain mechanism of non-correspondence between diseases severity and compression degree of the spinal cord in cervical spondylotic myelopathy (CSM) patients and to test the utility of brain imaging biomarkers for predicting prognosis of CSM.

Methods

We calculated voxel-wise zALFF from 54 CSM patients and 50 healthy controls using resting-state fMRI data. In analysis 1, we identified the brain regions exhibited significant differences of zALFF between CSM patients and healthy controls. In analyses 2 through 3, we investigated the zALFF differences between light-symptom CSM patients and severe-symptom CSM patients while carefully matching the degree of compression between these two groups. In analysis 4, we tested the utility of zALFF within the primary motor cortex (M1) for predicting the prognosis of CSM.

Results

We found that (1) compared with the healthy controls, CSM patients exhibited higher ALFF within left M1, bilateral superior frontal gyrus, and lower zALFF within right precuneus and calcarine, suggesting altered brain neural activity in CSM patients; (2) after matching the compression degree, the CSM patients with more severe clinical symptoms exhibited higher zALFF within M1, indicating cortical function contributes to disease’s severity of CSM; (3) taking the M1 zALFF as features in the prognosis prediction model improves the prediction accuracy, indicating that the M1 zALFF provide additional value for predicting the prognosis of CSM patients following decompression surgery.

Conclusion

The functional state of M1 contributes to the disease’s severity of CSM and can provide complementary information for predicting the prognosis of CSM following decompression surgery.

Key Points

• Cervical spondylotic myelopathy (CSM) patients exhibited increased zALFF within the primary motor cortex (M1), bilateral superior frontal gyrus, and decreased zALFF within the right precuneus and calcarine.

• After matching the compression degree, the CSM patients with more severe clinical symptoms exhibited higher zALFF within M1, indicating cortical function contributes to disease severity of CSM.

• zALFF within M1 provided additional value for predicting the prognosis of CSM patients.

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Titel: Functional MRI evidence for primary motor cortex plasticity contributes to the disease’s severity and prognosis of cervical spondylotic myelopathy patients
verfasst von: Rui Zhao
Xing Guo
Yang Wang
YingChao Song
Qian Su
HaoRan Sun
Meng Liang
Yuan Xue
Publikationsdatum: 14.01.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2022
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-021-08488-3

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Functional MRI evidence for primary motor cortex plasticity contributes to the disease’s severity and prognosis of cervical spondylotic myelopathy patients