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13.03.2021 | Review Article

Functional MRI in Parkinson’s disease with freezing of gait: a systematic review of the literature

verfasst von: Wenjing Song, Hafiz Khuram Raza, Li Lu, Zuohui Zhang, Jie Zu, Wei Zhang, Liguo Dong, Chuanying Xu, Xiangyao Gong, Bingchen Lv, Guiyun Cui

Erschienen in: Neurological Sciences | Ausgabe 5/2021

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Abstract

Background

Freezing of gait (FOG), a common and disabling symptom of Parkinson’s disease (PD), is characterized by an episodic inability to generate effective stepping. Functional MRI (fMRI) has been used to evaluate abnormal brain connectivity patterns at rest and brain activation patterns during specific tasks in patients with PD-FOG. This review has examined the existing functional neuroimaging literature in PD-FOG, including those with treatment. Summarizing these articles provides an opportunity for a better understanding of the underlying pathophysiology in PD-FOG.

Methods

According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we performed a literature review of studies using fMRI to investigate the underlying pathophysiological mechanisms of PD-FOG.

Results

We initially identified 201 documents. After excluding the duplicates, reviews, and other irrelevant articles, 39 articles were finally identified, including 18 task-based fMRI studies and 21 resting-state fMRI studies.

Conclusions

Studies using fMRI techniques to evaluate PD-FOG have found dysfunctional connectivity in widespread cortical and subcortical regions. Standardized imaging protocols and detailed subtypes of PD-FOG are furthered required to elucidate current findings.

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Titel: Functional MRI in Parkinson’s disease with freezing of gait: a systematic review of the literature
verfasst von: Wenjing Song
Hafiz Khuram Raza
Li Lu
Zuohui Zhang
Jie Zu
Wei Zhang
Liguo Dong
Chuanying Xu
Xiangyao Gong
Bingchen Lv
Guiyun Cui
Publikationsdatum: 13.03.2021
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 5/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05121-5

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Functional MRI in Parkinson’s disease with freezing of gait: a systematic review of the literature

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