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Erschienen in: BMC Gastroenterology 1/2018

Open Access 01.12.2018 | Research article

Functional outcomes in Hirschsprung disease patients after transabdominal Soave and Duhamel procedures

verfasst von: Amira Widyasari, Winona Alda Pavitasari, Andi Dwihantoro, Gunadi

Erschienen in: BMC Gastroenterology | Ausgabe 1/2018

Abstract

Background

Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-through remain the most important markers of good outcome. We aimed to compare the functional outcomes in HSCR patients following Soave and Duhamel procedures.

Methods

Krickenbeck classification was utilized to determine VBM, soiling and constipation for patients who underwent Soave and Duhamel pull-through at Dr. Sardjito Hospital, Indonesia from 2013 to 2016.

Results

Fifty-three patients were ascertained (Soave: 23 males and 2 females vs. Duhamel: 22 males and 6 females, p = 0.26). Ninety-three and 88% patients had a VBM following Duhamel and Soave pull-through, respectively (p = 0.66). Constipation frequency was significantly higher in Soave than Duhamel groups (24% vs. 4%; p = 0.04) with OR of 8.5 (95% CI = 1.0–76.7), whereas soiling rate was similar between Duhamel (21%) and Soave (8%) groups (p = 0.26). Furthermore, the risk of constipation was increased ~ 21.7-fold in female patients after Soave procedure and was almost statistically significant (p = 0.05).

Conclusions

The constipation rate is higher in patients who underwent Soave than Duhamel procedure, but the VBM and soiling frequencies are similar. The constipation risk following Soave pull-through might be increased by the female gender. Furthermore, a multicenter study with a larger sample of patients is necessary to clarify and confirm our findings.
Hinweise
A correction to this article is available online at https://​doi.​org/​10.​1186/​s12876-018-0844-5.
The original online version of this article was revised: The name of the second author should be Pavitasari.
A Correction to this article is available online at https://​doi.​org/​10.​1186/​s12876-021-01894-3.
Abkürzungen
HSCR
Hirschsprung disease
mo
months
TCA
Total colonic aganglionosis
VBM
Voluntary bowel movement

Background

Hirschsprung disease (HSCR) is caused by the migration failure of neural crest cells during intestinal development, resulting in an aganglionic colon and causing a functional obstruction in children [1, 2]. According to the length of aganglionosis, HSCR can be classified as follows: 1) short-segment, 2) long-segment, and 3) total colonic aganglionosis (TCA), with a male-to-female ratio of approximately 4:1 [1].
The goal of HSCR treatment is surgical resection of the aganglionic bowel and pulling the ganglionated bowel through to a point just above the dentate line [3]. Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes [48]. There is currently some debate over which pull-through technique offers the best outcome [9]. The voluntary bowel movement (VBM) and the absence of soiling or constipation following pull-through remain the most important markers of good outcome [9]. This study aimed to compare the functional outcomes including VBM, soiling and constipation in HSCR patients following the Soave and Duhamel procedures.

Methods

Patients

A retrospective study was conducted with children < 18 year of age with HSCR at Dr. Sardjito Hospital, a University Teaching Hospital [10] in Yogyakarta, Indonesia from January 2012 to December 2016. Fifty-three patients were ascertained (Soave: 23 males and 2 females vs. Duhamel: 22 males and 6 females, p = 0.26), corresponding to a sex ratio of 5.6:1 (Table 1).
Table 1
Clinical characteristics of HSCR patients who underwent Soave and Duhamel procedures
Characteristics
Soave
n (%)
Duhamel
n (%)
p-value
Gender
 ▪ Male
23 (92)
22 (79)
0.26
 ▪ Female
2 (8)
6 (21)
 
Aganglionosis type
  
0.67
 ▪ Short-segment
23 (92)
24 (86)
 
 ▪ Long-segment
2 (8)
4 (14)
 
Age of HSCR diagnosis
24 mo (0.5–218 mo)
22.5 mo (1–163 mo)
0.93
Age of pull-through
  
0.66
 ▪ ≥3 years old
11 (56)
14 (50)
 
 ▪ < 3 years old
14 (44)
14 (50)
 
Length of follow-up
17.0 ± 14.3 mo
15.5 ± 14.6 mo
0.71
Nutritional status
  
0.38
 ▪ Undernourished
18 (72)
23 (82)
 
 ▪ Well-nourished
7 (28)
5 (18)
 
mo months, HSCR Hirschsprung diseases
Diagnosis of HSCR in our hospital was established according to the clinical manifestation, contrast enema, and histopathology findings. The pathologist utilized the hematoxylin and eosin staining and/or S100 immunohistochemistry for the histopathology diagnosis of HSCR [1116].
The two-staged Soave and colonic Duhamel pull-through were conducted at our hospital based on our previous study [15]. The definitive surgical procedures were performed by two experienced pediatric surgeons in our institution, and one surgeon only performed one of the techniques. All HSCR patients showed the level of the aganglionic zone at the sigmoid colon, except with six patients which was at the descending colon. Furthermore, there were no TCA patients in our study.
We defined the age of pull-through with the following criteria: ≥3 years old and < 3 years old since surgery in older children presents specific perioperative challenges that might impact the outcomes [17].
In addition, we classified the nutritional status of HSCR patients as follows: undernourished and well-nourished since the peri-operative malnutrition was associated with the functional outcomes following pull-through [3]. Undernourished was defined as weight-for-age Z score < − 2 [18].
This study was approved by the Institutional Review Board of the Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia (KE/FK/1356/EC/2015). Written informed consent was obtained from all parents for participating this study.

Functional outcomes

Krickenbeck classification was used to evaluate the functional outcomes, including VBM, soiling and constipation, according to previous studies [1921]. VBM was determined as feeling an urge to defecate, the capacity to verbalize this feeling, and the ability to hold the bowel movement. Soiling was classified into 3 grades as follows: a) grade 1, occasionally soiling (up to once or twice per week); b) grade 2, soiling every day but no social problems; and c) grade 3, constant soiling with social problems, whereas constipation consists of 3 grades: a) grade 1, manageable by changes in diet; b) grade 2, requires laxatives; and c) grade 3, resistant to laxatives and diet [19]. The functional outcomes were assessed by the pediatric surgeons in children ≥3 years old since toilet training is expected by this age [9].
To further investigate the functional outcomes in our HSCR patients after pull-through, we performed a contrast enema to visualize the anatomy after the initial surgery and give insight into the colon motility and any structural defect, or if necessary, a rectal biopsy to rule out a transition zone pull-through or retained aganglionosis, as suggested by previous study [22].

Statistical analysis

Data were presented as number/percentages and median/mean for categorical and continuous variables, respectively. The Fischer exact, chi-square, Mann-Whitney U, and t tests were used to evaluate the differences between groups.

Results

We used ICD-10 codes (International Statistical Classification of Diseases and Related Health Problems, 10th Revision) (Q43.1: Hirschsprung disease) to identify patients diagnosed with HSCR and examined 65 medical records. We excluded 12 subjects due to incomplete medical records, thus, we further analyzed 53 infants.
Fifty-three HSCR patients (Soave = 25 vs. Duhamel = 28) had complete data for final analysis (Table 1). Most patients were having short-segment HSCR (89%) and were undernourished (77%). None of the clinical characteristics of HSCR patients showed any difference between the two surgical methods (Table 1).
The VBM rates were 93% and 88% in the Duhamel and Soave groups, respectively, but the differences did not reach a significant level (p = 0.66) (Table 2). The soiling frequency was not statistically significant between the Duhamel and the Soave groups (21% vs. 8%, p = 0.26) (Tables 2 and 4). In contrast, the constipation rate was significantly higher in the Soave than the Duhamel groups (24% vs. 4%, p = 0.04) with OR of 8.5 (95% CI = 1.0–76.7) (Tables 2 and 5). Furthermore, four patients underwent a contrast enema and showed a dilated (hypomotile) colon, a nondilated (hypermotile) colon and an anatomic stricture in one, two and one patients, respectively, while none of the patients underwent a rectal biopsy.
Table 2
Functional outcomes in HSCR patients after Soave and Duhamel procedures according to Krickenbeck classification
Functional outcomes
Soave (n, %)
Duhamel (n, %)
p-value
Voluntary bowel movements
22/25 (88)
26/28 (93)
0.66
Soiling
 √ Grade 1
2/25 (8)
5/28 (18)
0.26
 √ Grade 2
0
1/28 (3)
 
 √ Grade 3
0
0
 
Constipation
 √ Grade 1
1/25 (4)
1/28 (4)
0.04*
 √ Grade 2
5/25 (20)
0
 
 √ Grade 3
0
0
 
*, significant (p < 0.05)
Next, we analyzed the impact of the gender, aganglionosis type, nutritional status, and age at pull-through on the VBM, soiling and constipation (Tables 3, 4 and 5, respectively). None of the factors affected the functional outcomes after pull-through, but an almost significant effect was observed in the Soave group: the female patients had ~ 21.7-fold higher risk to have constipation after surgery than the male patients (p = 0.05) (Table 5).
Table 3
Voluntary bowel movements in HSCR patients after Soave and Duhamel pull-through
 
Duhamel (n, %)
Soave (n, %)
p-value
OR (95% CI)
  
Duhamel
Soave
Duhamel
Soave
Voluntary bowel movements
26/28 (93)
22/25 (88)
0.66
 
1.7 (0.3–11.1)
 
Gender
 √ Male
20/26 (77)
20/22 (91)
0.78
0.92
0.6 (0.03–14.9)
1.2 (0.05–29.9)
 √ Female
6/26 (23)
2/22 (9)
    
Aganglionosis type
 √ Long-segment
3/26 (11.5)
2/22 (9)
0.19
0.92
0.1 (0.01–2.7)
0.9 (0.03–21.8)
 √ Short-segment
23/26 (88.5)
20/22 (91)
    
Nutritional status
 √ Undernourished
21/26 (81)
17/22 (77)
0.88
0.15
0.8 (0.03–18.8)
6.8 (0.5–91.5)
 √ Well-nourished
5/26 (19)
5/22 (23)
    
Age of pull-through
 √ ≥3 years old
14/26 (54)
11/22 (50)
0.27
0.21
5.8 (0.3–132.6)
7.0 (0.3–151.4)
 √ < 3 years old
12/26 (46)
11/22 (50)
    
Table 4
Soiling frequency in HSCR patients after Soave and Duhamel pull-through
 
Duhamel (n, %)
Soave (n, %)
ph-value
OR (95% CI)
  
Duhamel
Soave
Duhamel
Soave
Soiling frequency
6/28 (21)
2/25 (8)
0.26
 
3.1 (0.6–17.2)
 
Gender
 √ Male
6/6 (100)
2/2 (100)
0.29
0.75
5.1 (0.3–104.6)
0.6 (0.02–15.9)
 √ Female
0
0
    
Aganglionosis type
 √ Long-segment
0
0
0.46
0.75
0.3 (0.01–6.7)
1.7 (0.06–46.9)
 √ Short-segment
6/6 (100)
2/2 (100)
    
Nutritional status
 √ Undernourished
5/6 (83)
2/2 (100)
0.93
0.61
1.1 (0.1–12.3)
2.2 (0.1–53.4)
 √ Well-nourished
1/6 (17)
0
    
Age of pull-through
 √ ≥3 years old
4/6 (67)
2/2 (100)
0.36
0.21
2.4 (0.4–15.9)
7.6 (0.3–177.2)
 √ < 3 years old
2/6 (33)
0
    
Table 5
Constipation rate in HSCR patients after Soave and Duhamel pull-through
 
Soave (n, %)
Duhamel (n, %)
p-value
OR (95% CI)
  
Soave
Duhamel
Soave
Duhamel
Constipation frequency
6/25 (24)
1/28 (4)
0.04*
 
8.5 (1.0–76.7)
 
Gender
 √ Female
2/6 (33)
1/1 (100)
0.05
0.14
21.7 (0.9–534.1)
12.2 (0.4–344.1)
 √ Male
4/6 (67)
0
    
Aganglionosis type
 √ Long-segment
0
0
0.70
0.75
0.5 (0.02–12.8)
1.7 (0.1–49.9)
 √ Short-segment
6/6 (100)
1/1 (100)
    
Nutritional status
 √ Undernourished
5/6 (83)
1/1 (100)
0.49
0.87
2.3 (0.2–24.3)
0.8 (0.03–21.5)
 √ Well-nourished
1/6 (17)
0
    
Age of pull-through
 √ ≥3 years old
4/6 (67)
0
0.21
0.49
3.4 (0.5–23.8)
0.3 (0.01–8.3)
 √ < 3 years old
2/6 (33)
1/1 (100)
    

Discussion

We clearly show that the VBM and soiling frequencies are similar between the Duhamel and Soave groups, but the constipation rate is higher in the Soave than Duhamel groups. The risk of constipation following the Soave procedure is increased ~ 8.5-fold higher than the Duhamel procedure. This finding might be caused by an anastomotic stricture or “rolling down” of the rectal muscular cuff following the Soave procedure [23]. If there was an anatomic stricture identified in our patients after evaluation by a contrast enema, we managed them with serial dilatation. Also, the constipation rates following the Soave and Duhamel procedures in our study were similar (24% vs. 25%) and lower than (4% vs. 25%) previous study [20].
It has been reported that the HSCR patients who underwent Duhamel procedure will have less soiling [22]. The soiling in the Duhamel group might be caused by the “overflow” incontinence secondary to constipation since the Duhamel technique results in less possibility for the anal canal damage [21, 22, 24]. However, our study showed that the soiling frequency was similar between the Duhamel and the Soave groups. Furthermore, our study focused on the development of soiling and constipation following pull-through, while the enterocolitis after surgery in our cohort patients has been previously reported [15]. As for the VBM, its frequency in this series reached ~ 90% HSCR patients after pull-through and was higher than previous study (67%) [20].
Interestingly, in the Soave group, the female patients had 21-fold higher risk to have constipation following the Soave procedure than the male patients. In the general population without any other gastrointestinal disorders, it has been shown that females have higher constipation rate due to hormonal factors [25]. Unfortunately, we do not have any data on the constipation rate in HSCR children after pull-through who were going through or already had passed puberty. Therefore, it is interesting to conduct a cohort study to compare the constipation frequency between adolescent females and male HSCR patients.
The functional outcomes after pull-through were also associated with the peri-operative malnutrition [3]. Our study showed that there was no association between nutritional status of HSCR patients and their functional outcomes following pull-through. It should be noted that the small sample size, which was a weakness of our study, suggests that a larger sample of patients needs to be ascertained to clarify our findings.
Our study utilized the Krickenbeck classification to evaluate the functional outcomes following pull-through procedure according to previous studies [1921]. However, it should be noted that the Krickenbeck classification was originally established for patients with anorectal malformation (ARM). There are different anatomies and associated anomalies between HSCR and ARM patients. The patients with HSCR possess normal anal canal and sphincter, and usually do not have any anomaly in the spinal cord and vertebrae. Therefore, our results should be interpreted with some caution given those differences. Caution should be also taken when generalizing about the findings since this is a mono-institutional study.
The algorithm has been proposed to improve the outcome of HSCR patients with soiling and constipation after pull-through [22]. The pediatric surgeon should begin with a detailed history and physical examination focused on the patient’s bowel habits and the method of the first pull-through, followed by several examinations, such as: contrast enema and rectal biopsy. Once the etiology of the symptoms after pull-through is established, it will be followed by specific treatment accordingly [22]. Moreover, our study also implies that the pediatric surgeon should monitor and evaluate closely the functional outcomes of their HSCR patients after pull-through to determine appropriate follow-up and management.

Conclusions

The constipation rate is higher in patients who underwent Soave than Duhamel procedure, but the VBM and soiling frequencies are similar. The constipation risk following Soave pull-through might be increased by the female gender. Furthermore, a multicenter study with a larger sample of patients is necessary to clarify and confirm our findings.

Acknowledgements

We are thankful to Harini Natalia for ethical clearance management. We are also grateful for the English Services Center, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, for editing the grammar and proofreading of our manuscript. We are also thankful to Dian Nirmala Sirait, Alvin Santoso Kalim and all those who provided excellent technical support and assistance during the study.

Availability of data and materials

All data generated or analyzed during this study are included in the submission. The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
This study was approved by the Institutional Review Board of the Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia (KE/FK/1356/EC/2015). Written informed consent was obtained from all parents for participating this study.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
Literatur
1.
Zurück zum Zitat Tam PK. Hirschsprung’s disease: a bridge for science and surgery. J Pediatr Surg. 2016;51:18–22.CrossRef Tam PK. Hirschsprung’s disease: a bridge for science and surgery. J Pediatr Surg. 2016;51:18–22.CrossRef
2.
Zurück zum Zitat Amiel J, Sproat-Emison E, Garcia-Barcelo M, et al. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet. 2008;45:1–14.CrossRef Amiel J, Sproat-Emison E, Garcia-Barcelo M, et al. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet. 2008;45:1–14.CrossRef
3.
Zurück zum Zitat Teitelbaum DH, Cilley RE, Sherman NJ, et al. A decade of experience with the primary pull-through for Hirschsprung disease in the newborn period: a multicenter analysis of outcomes. Ann Surg. 2000;232:372–80.CrossRef Teitelbaum DH, Cilley RE, Sherman NJ, et al. A decade of experience with the primary pull-through for Hirschsprung disease in the newborn period: a multicenter analysis of outcomes. Ann Surg. 2000;232:372–80.CrossRef
4.
Zurück zum Zitat Nasr A, Haricharan RN, Gamarnik J, Langer JC. Transanal pullthrough for Hirschsprung disease: matched case-control comparison of Soave and Swenson techniques. J Pediatr Surg. 2014;49:774–6.CrossRef Nasr A, Haricharan RN, Gamarnik J, Langer JC. Transanal pullthrough for Hirschsprung disease: matched case-control comparison of Soave and Swenson techniques. J Pediatr Surg. 2014;49:774–6.CrossRef
5.
Zurück zum Zitat Nah SA, de Coppi P, Kiely EM, et al. Duhamel pull-through for Hirschsprung disease: a comparison of open and laparoscopic techniques. J Pediatr Surg. 2012;47:308–12.CrossRef Nah SA, de Coppi P, Kiely EM, et al. Duhamel pull-through for Hirschsprung disease: a comparison of open and laparoscopic techniques. J Pediatr Surg. 2012;47:308–12.CrossRef
6.
Zurück zum Zitat De La Torre L, Langer JC. Transanal endorectal pull-through for Hirschsprung disease: technique, controversies, pearls, pitfalls, and an organized approach to the management of postoperative obstructive symptoms. Semin Pediatr Surg. 2010;19:96–106.CrossRef De La Torre L, Langer JC. Transanal endorectal pull-through for Hirschsprung disease: technique, controversies, pearls, pitfalls, and an organized approach to the management of postoperative obstructive symptoms. Semin Pediatr Surg. 2010;19:96–106.CrossRef
7.
Zurück zum Zitat Levitt MA, Hamrick MC, Eradi B, Bischoff A, Hall J, Pena A. Transanal, full-thickness, Swenson-like approach for Hirschsprung disease. J Pediatr Surg. 2013;48:2289–95.CrossRef Levitt MA, Hamrick MC, Eradi B, Bischoff A, Hall J, Pena A. Transanal, full-thickness, Swenson-like approach for Hirschsprung disease. J Pediatr Surg. 2013;48:2289–95.CrossRef
8.
Zurück zum Zitat Rochadi, Haryana SM, Sadewa AH, Gunadi. Effect of RET c.2307T>G polymorphism on the outcomes of posterior sagittal neurectomy for Hirschsprung disease procedure in Indonesian population. Int Surg. 2014;99(6):802.CrossRef Rochadi, Haryana SM, Sadewa AH, Gunadi. Effect of RET c.2307T>G polymorphism on the outcomes of posterior sagittal neurectomy for Hirschsprung disease procedure in Indonesian population. Int Surg. 2014;99(6):802.CrossRef
9.
Zurück zum Zitat Aworanti OM, Mcdowell DT, Martin IM, Hung J, Quinn F. Comparative review of functional outcomes post surgery for Hirschsprung's disease utilizing the paediatric incontinence and constipation scoring system. Pediatr Surg Int. 2012;28:1071–8.CrossRef Aworanti OM, Mcdowell DT, Martin IM, Hung J, Quinn F. Comparative review of functional outcomes post surgery for Hirschsprung's disease utilizing the paediatric incontinence and constipation scoring system. Pediatr Surg Int. 2012;28:1071–8.CrossRef
11.
Zurück zum Zitat Gunadi, Kapoor A, Ling AY, et al. Effects of RET and NRG1 polymorphisms in Indonesian patients with Hirschsprung disease. J Pediatr Surg. 2014;49:1614–8.CrossRef Gunadi, Kapoor A, Ling AY, et al. Effects of RET and NRG1 polymorphisms in Indonesian patients with Hirschsprung disease. J Pediatr Surg. 2014;49:1614–8.CrossRef
12.
Zurück zum Zitat Gunadi, Dwihantoro A, Iskandar I, Makhmudi A, Rochadi. Accuracy of polymerase chain reaction-restriction fragment length polymorphism for RET rs2435357 genotyping as Hirschsprung risk. J Surg Res. 2016;203:91–4.CrossRef Gunadi, Dwihantoro A, Iskandar I, Makhmudi A, Rochadi. Accuracy of polymerase chain reaction-restriction fragment length polymorphism for RET rs2435357 genotyping as Hirschsprung risk. J Surg Res. 2016;203:91–4.CrossRef
13.
Zurück zum Zitat Gunadi, Makhmudi A, Agustriani N, Rochadi. Effects of SEMA3 polymorphisms in Hirschsprung disease patients. Pediatr Surg Int. 2016;32:1025–8.CrossRef Gunadi, Makhmudi A, Agustriani N, Rochadi. Effects of SEMA3 polymorphisms in Hirschsprung disease patients. Pediatr Surg Int. 2016;32:1025–8.CrossRef
14.
Zurück zum Zitat Setiadi JA, Dwihantoro A, Iskandar K, Heriyanto DS, Gunadi. The utility of the hematoxylin and eosin staining in patients with suspected Hirschsprung disease. BMC Surg. 2017;17:71.CrossRef Setiadi JA, Dwihantoro A, Iskandar K, Heriyanto DS, Gunadi. The utility of the hematoxylin and eosin staining in patients with suspected Hirschsprung disease. BMC Surg. 2017;17:71.CrossRef
16.
Zurück zum Zitat Gunadi, Sunardi M, Budi NYP, Kalim AS, Iskandar K, Dwihantoro A. The impact of down-regulated SK3 expressions on Hirschsprung disease. BMC Med Genet. 2018;19:24.CrossRef Gunadi, Sunardi M, Budi NYP, Kalim AS, Iskandar K, Dwihantoro A. The impact of down-regulated SK3 expressions on Hirschsprung disease. BMC Med Genet. 2018;19:24.CrossRef
17.
Zurück zum Zitat Ademuyiwa AO, Bode CO, Lawal OA, Seyi-Olajide J. Swenson’s pull-through in older children and adults: peculiar peri-operative challenges of surgery. Int J Surg. 2011;9:652–4.CrossRef Ademuyiwa AO, Bode CO, Lawal OA, Seyi-Olajide J. Swenson’s pull-through in older children and adults: peculiar peri-operative challenges of surgery. Int J Surg. 2011;9:652–4.CrossRef
18.
Zurück zum Zitat World Health Organization. Training course on child growth assessment. Geneva: WHO; 2008. World Health Organization. Training course on child growth assessment. Geneva: WHO; 2008.
19.
Zurück zum Zitat Holschneider A, Hutson J, Peña A, et al. Preliminary report on the international conference for the development of standards for the treatment of anorectal malformations. J Pediatr Surg. 2005;40:1521–6.CrossRef Holschneider A, Hutson J, Peña A, et al. Preliminary report on the international conference for the development of standards for the treatment of anorectal malformations. J Pediatr Surg. 2005;40:1521–6.CrossRef
20.
Zurück zum Zitat Stensrud KJ, Emblem R, Bjørnland K. Functional outcome after operation for Hirschsprung disease--transanal vs transabdominal approach. J Pediatr Surg. 2010;45:1640–4.CrossRef Stensrud KJ, Emblem R, Bjørnland K. Functional outcome after operation for Hirschsprung disease--transanal vs transabdominal approach. J Pediatr Surg. 2010;45:1640–4.CrossRef
21.
Zurück zum Zitat Wester T, Granström AL. Hirschsprung disease-bowel function beyond childhood. Semin Pediatr Surg. 2017;26:322–7.CrossRef Wester T, Granström AL. Hirschsprung disease-bowel function beyond childhood. Semin Pediatr Surg. 2017;26:322–7.CrossRef
22.
Zurück zum Zitat Levitt MA, Dickie B, Peña A. The Hirschsprungs patient who is soiling after what was considered a “successful” pull-through. Semin Pediatr Surg. 2012;21:344–53.CrossRef Levitt MA, Dickie B, Peña A. The Hirschsprungs patient who is soiling after what was considered a “successful” pull-through. Semin Pediatr Surg. 2012;21:344–53.CrossRef
23.
Zurück zum Zitat Langer JC, Rollins MD, Levitt M, et al. Guidelines for the management of postoperative obstructive symptoms in children with Hirschsprung disease. Pediatr Surg Int. 2017;33:523–6.CrossRef Langer JC, Rollins MD, Levitt M, et al. Guidelines for the management of postoperative obstructive symptoms in children with Hirschsprung disease. Pediatr Surg Int. 2017;33:523–6.CrossRef
24.
Zurück zum Zitat Langer JC. Persistent obstructive symptoms after surgery for Hirschsprung disease: development of a diagnostic and therapeutic algorithm. J Pediatr Surg. 2004;39:1458–62.CrossRef Langer JC. Persistent obstructive symptoms after surgery for Hirschsprung disease: development of a diagnostic and therapeutic algorithm. J Pediatr Surg. 2004;39:1458–62.CrossRef
25.
Zurück zum Zitat Peppas G, Alexiou VG, Mourtzoukou E, Falagas ME. Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterol. 2008;8:5.CrossRef Peppas G, Alexiou VG, Mourtzoukou E, Falagas ME. Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterol. 2008;8:5.CrossRef
Metadaten
Titel
Functional outcomes in Hirschsprung disease patients after transabdominal Soave and Duhamel procedures
verfasst von
Amira Widyasari
Winona Alda Pavitasari
Andi Dwihantoro
Gunadi
Publikationsdatum
01.12.2018
Verlag
BioMed Central
Erschienen in
BMC Gastroenterology / Ausgabe 1/2018
Elektronische ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-018-0783-1

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