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Erschienen in: Annals of Surgical Oncology 5/2017

30.01.2017 | Health Services Research and Global Oncology

Functional Status is a Predictor of Postoperative Complications After Cancer Surgery in the Very Old

verfasst von: Marcos Daniel Saraiva, MD, Theodora Karnakis, MD, PhD, Luiz Antonio Gil-Junior, MD, Julio Cesar Oliveira, MD, Claudia Kimie Suemoto, MD, PhD, MS, Wilson Jacob-Filho, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 5/2017

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Abstract

Background

The association between preoperative functional status and postoperative complications after cancer surgery is very well described in the ‘youngest old’ population; however, limited information is available for the very old (i.e. those aged 80 years and older).

Objective

Our aim was to evaluate whether functional status, expressed as metabolic equivalents (METs), is a predictor of adverse postoperative outcomes in very old patients.

Methods

In a retrospective cohort study, we included all patients aged 80 years or older who underwent elective oncological surgery at a tertiary hospital in Brazil in 2011. The primary outcome was postoperative complications up to 30 days after surgery. Functional status was evaluated using a simple questionnaire, which classified participants into three groups based on METs. We used logistic regression models to investigate the association between functional status and the occurrence of complications, adjusted for possible confounders.

Results

We analyzed data from 138 patients aged 80 years or older. The mean age of the sample was 84.2 ± 4.2 years and 52% were female; 65% of the procedures were classified as low risk and 35% were classified as intermediate risk. Regarding functional status, 72% of the sample had a performance equivalent to fewer than 4 METs, 27% had 4–6 METs, and 1% had more than 6 METs. Postoperative complications were observed in 25%, and the mortality rate was 2%. Better functional status was associated with reduced odds of postoperative complications in multivariate analysis (odds ratio 0.11, 95% confidence interval 0.02–0.85; p = 0.034).

Conclusion

Functional status seems to be related to surgical morbidity in the very old.
Literatur
1.
Zurück zum Zitat Rivoirard R, Chargari C, Trone JC, Falk AT, Guy JB, Eddekaoui H, et al. General management of nonagenarian patients: a review of the literature. Swiss Med Wkly. 2014;144:w14059.PubMed Rivoirard R, Chargari C, Trone JC, Falk AT, Guy JB, Eddekaoui H, et al. General management of nonagenarian patients: a review of the literature. Swiss Med Wkly. 2014;144:w14059.PubMed
2.
Zurück zum Zitat Dewan SK, Zheng SB, Xia SJ. Preoperative geriatric assessment: comprehensive, multidisciplinary and proactive. Eur J Intern Med. 2012;23(6):487–94.CrossRefPubMed Dewan SK, Zheng SB, Xia SJ. Preoperative geriatric assessment: comprehensive, multidisciplinary and proactive. Eur J Intern Med. 2012;23(6):487–94.CrossRefPubMed
3.
Zurück zum Zitat Audisio RA, Bozzetti F, Gennari R, Jaklitsch MT, Koperna T, Longo WE, et al. The surgical management of elderly cancer patients: recommendations of the SIOG surgical task force. Eur J Cancer. 2004;40(7):926–38.CrossRefPubMed Audisio RA, Bozzetti F, Gennari R, Jaklitsch MT, Koperna T, Longo WE, et al. The surgical management of elderly cancer patients: recommendations of the SIOG surgical task force. Eur J Cancer. 2004;40(7):926–38.CrossRefPubMed
4.
Zurück zum Zitat Huisman MG, Kok M, de Bock GH, van Leeuwen BL. Delivering tailored surgery to older cancer patients: preoperative geriatric assessment domains and screening tools—a systematic review of systematic reviews. Eur J Surg Oncol. 2017;43(1):1–14.CrossRefPubMed Huisman MG, Kok M, de Bock GH, van Leeuwen BL. Delivering tailored surgery to older cancer patients: preoperative geriatric assessment domains and screening tools—a systematic review of systematic reviews. Eur J Surg Oncol. 2017;43(1):1–14.CrossRefPubMed
5.
Zurück zum Zitat Cicerchia M, Ceci M, Locatelli C, Gianni W, Repetto L. Geriatric syndromes in peri-operative elderly cancer patients. Surg Oncol. 2010;19(3):131–9.CrossRefPubMed Cicerchia M, Ceci M, Locatelli C, Gianni W, Repetto L. Geriatric syndromes in peri-operative elderly cancer patients. Surg Oncol. 2010;19(3):131–9.CrossRefPubMed
6.
Zurück zum Zitat Chen RC, Royce TJ, Extermann M, Reeve BB. Impact of age and comorbidity on treatment and outcomes in elderly cancer patients. Semin Radiat Oncol. 2012;22(4):265–71.CrossRefPubMed Chen RC, Royce TJ, Extermann M, Reeve BB. Impact of age and comorbidity on treatment and outcomes in elderly cancer patients. Semin Radiat Oncol. 2012;22(4):265–71.CrossRefPubMed
7.
Zurück zum Zitat Gong CS, Yook JH, Oh ST, Kim BS. Comparison of survival of surgical resection and conservative treatment in patients with gastric cancer aged 80 years or older: a single-center experience. Ann Surg Treat Res. 2016;91(5):219–225.CrossRefPubMedPubMedCentral Gong CS, Yook JH, Oh ST, Kim BS. Comparison of survival of surgical resection and conservative treatment in patients with gastric cancer aged 80 years or older: a single-center experience. Ann Surg Treat Res. 2016;91(5):219–225.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Guerra M, Neves P, Miranda J. Surgical treatment of non-small-cell lung cancer in octogenarians. Interact Cardiovasc Thorac Surg. 2013;16(5):673–80.CrossRefPubMedPubMedCentral Guerra M, Neves P, Miranda J. Surgical treatment of non-small-cell lung cancer in octogenarians. Interact Cardiovasc Thorac Surg. 2013;16(5):673–80.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat PACE participants, Audisio RA, Pope D, Ramesh HS, Gennari R, van Leeuwen BL, et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG Surgical Task Force prospective study. Crit Rev Oncol Hematol. 2008;65(2):156–63. PACE participants, Audisio RA, Pope D, Ramesh HS, Gennari R, van Leeuwen BL, et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG Surgical Task Force prospective study. Crit Rev Oncol Hematol. 2008;65(2):156–63.
10.
Zurück zum Zitat Feng MA, McMillan DT, Crowell K, Muss H, Nielsen ME, Smith AB. Geriatric assessment in surgical oncology: a systematic review. J Surg Res. 2015;193(1):265–72.CrossRefPubMed Feng MA, McMillan DT, Crowell K, Muss H, Nielsen ME, Smith AB. Geriatric assessment in surgical oncology: a systematic review. J Surg Res. 2015;193(1):265–72.CrossRefPubMed
11.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–213.CrossRefPubMedPubMedCentral Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–213.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Hlatky MA, Boineau RE, Higginbotham MB, Lee KL, Mark DB, Califf RM, et al. A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index). Am J Cardiol. 1989;64:651–54.CrossRefPubMed Hlatky MA, Boineau RE, Higginbotham MB, Lee KL, Mark DB, Califf RM, et al. A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index). Am J Cardiol. 1989;64:651–54.CrossRefPubMed
13.
Zurück zum Zitat Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beckman JA, Bozkurt B, American College of Cardiology; American Heart Association, et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(22):e77–e137.CrossRefPubMed Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beckman JA, Bozkurt B, American College of Cardiology; American Heart Association, et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(22):e77–e137.CrossRefPubMed
14.
Zurück zum Zitat Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41.CrossRefPubMed Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41.CrossRefPubMed
15.
Zurück zum Zitat World Health Organization. Nutritional anaemias: report of a WHO scientific group. Geneva: World Health Organization; 1968. World Health Organization. Nutritional anaemias: report of a WHO scientific group. Geneva: World Health Organization; 1968.
16.
Zurück zum Zitat Mukherjee D, Eagle KA. Perioperative cardiac assessment for noncardiac surgery. Circulation. 2003;107:2771–2774.CrossRefPubMed Mukherjee D, Eagle KA. Perioperative cardiac assessment for noncardiac surgery. Circulation. 2003;107:2771–2774.CrossRefPubMed
17.
Zurück zum Zitat Solaini L, Ministrini S, Coniglio A, Cavallari S, Molteni B, Baiocchi GL, et al. How could we identify the ‘old’ patient in gastric cancer surgery? A single centre cohort study. Int J Surg. 2006;34:174–179CrossRef Solaini L, Ministrini S, Coniglio A, Cavallari S, Molteni B, Baiocchi GL, et al. How could we identify the ‘old’ patient in gastric cancer surgery? A single centre cohort study. Int J Surg. 2006;34:174–179CrossRef
18.
Zurück zum Zitat Kristjansson SR, Farinella E, Gaskell S, Audisio RA. Surgical risk and post-operative complications in older unfit cancer patients. Cancer Treat Rev. 2009;35(6):499–502.CrossRefPubMed Kristjansson SR, Farinella E, Gaskell S, Audisio RA. Surgical risk and post-operative complications in older unfit cancer patients. Cancer Treat Rev. 2009;35(6):499–502.CrossRefPubMed
19.
Zurück zum Zitat Turrentine FE, Wang H, Simpson VB, Jones RS. Surgical risk factors, morbidity, and mortality in elderly patients. J Am Coll Surg 2006;203(6):865–877.CrossRefPubMed Turrentine FE, Wang H, Simpson VB, Jones RS. Surgical risk factors, morbidity, and mortality in elderly patients. J Am Coll Surg 2006;203(6):865–877.CrossRefPubMed
20.
Zurück zum Zitat Kristjansson SR, Spies C, Veering BTH, Silverstein JH, Vigano AAL, Mercadante S. Perioperative care of the elderly oncology patient: a report from the SIOG Task Force on the perioperative care of older patients with cancer. J Geriatr Oncol. 2012; 3(2):147–162.CrossRef Kristjansson SR, Spies C, Veering BTH, Silverstein JH, Vigano AAL, Mercadante S. Perioperative care of the elderly oncology patient: a report from the SIOG Task Force on the perioperative care of older patients with cancer. J Geriatr Oncol. 2012; 3(2):147–162.CrossRef
21.
Zurück zum Zitat Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol. 2007;25(14):1824–31.CrossRefPubMed Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol. 2007;25(14):1824–31.CrossRefPubMed
22.
Zurück zum Zitat Carbonell AL, Salhab RM, Giampaoli V, Cendoroglo MS, Chauffaille Mde L. A model for the functional assessment of elderly with myeloid neoplasms. Rev Bras Hematol Hemoter. 2015;37(2):109–114.CrossRefPubMedPubMedCentral Carbonell AL, Salhab RM, Giampaoli V, Cendoroglo MS, Chauffaille Mde L. A model for the functional assessment of elderly with myeloid neoplasms. Rev Bras Hematol Hemoter. 2015;37(2):109–114.CrossRefPubMedPubMedCentral
Metadaten
Titel
Functional Status is a Predictor of Postoperative Complications After Cancer Surgery in the Very Old
verfasst von
Marcos Daniel Saraiva, MD
Theodora Karnakis, MD, PhD
Luiz Antonio Gil-Junior, MD
Julio Cesar Oliveira, MD
Claudia Kimie Suemoto, MD, PhD, MS
Wilson Jacob-Filho, MD, PhD
Publikationsdatum
30.01.2017
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 5/2017
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-017-5783-9

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