Erschienen in:
04.08.2015 | Research Letter
GALNT2 mRNA levels are associated with serum triglycerides in humans
verfasst von:
Antonella Marucci, Davide Mangiacotti, Vincenzo Trischitta, Rosa Di Paola
Erschienen in:
Endocrine
|
Ausgabe 1/2016
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Excerpt
Atherogenic dyslipidemia, characterized by high triglycerides (TG) and low high density lipoprotein (HDL)-cholesterol levels, is a feature of patients with insulin resistance, obesity, and type 2 diabetes (T2D) [
1] and plays a major role in shaping the risk of cardiovascular disease. Both TG and HDL-cholesterol serum concentrations are under the control of both environmental factors and up to 95 genetic loci, unraveled by a very large genome-wide association study (GWAs) in approximately 100,000 individuals [
2]. Among these loci is
GALNT2, which encode for ppGal-NAc-T2, involved in O-linked glycosylation. Similarly, studies in rodents have shown that liver
GALNT2 expression modulates HDL-cholesterol concentrations [
2]. Based on such studies, it is conceivable that
GALNT2 expression changes play a role on TG and/or HDL-cholesterol levels. To gain further insights about this hypothesis,
GALNT2 expression was measured in peripheral white blood cells (PWBC), from 224 individuals with a wide range of TG and HDL-cholesterol levels, as well as other metabolic parameters and clinical conditions. …