Skip to main content
main-content

01.10.2008 | Research Article | Ausgabe 10/2008

Obesity Surgery 10/2008

Gastric Bypass Surgery in Rats Produces Weight Loss Modeling after Human Gastric Bypass

Zeitschrift:
Obesity Surgery > Ausgabe 10/2008
Autoren:
David S. Tichansky, John D. Boughter Jr., Jason Harper, A. Rebecca Glatt, Atul K. Madan
Wichtige Hinweise
Presented at the 24th Annual Meeting of the American Society for Bariatric Surgery; June 16, 2007; San Diego, CA.

Abstract

Background

The study of the mechanisms of weight loss after bariatric surgery requires an animal model that mimics the human procedure and subsequent weight loss. A rat model eliminates the cognitive efforts associated with human weight loss and gain.

Methods

A technique for gastric bypass (Roux-en-Y gastric bypass [RYGB]) was developed in Sprague–Dawley rats. A 1- to 2-cc pouch is created from the uppermost stomach using a linear stapler. A 10-cm biliopancreatic limb and 15-cm Roux limb are anastomosed side to side with running nonabsorbable suture. The gastrojejunostomy is created with a single layer of running nonabsorbable suture. Four rats underwent RYGB. Weight loss was compared to four sham rats that had a midline incision and left 60 min with an open abdomen before closure.

Results

RYGB rats lost an average of 16.5% body weight (BW) at 1 week, 22% BW at 2 weeks, 20% BW at 3 weeks, and 11% BW at 4 weeks. The RYGB rat’s weight was basically level after 4 weeks. The shams lost an average of 4% BW at 1 week, 1% BW at 2 weeks, and 0% BW at 3 weeks and gained an average of 2% at weeks. Subjectively, the RYGB rats were less interested in chow and frequently had chow left in their cage.

Conclusion

A Sprague–Dawley rat model for gastric bypass has been developed and yields approximately 11% BW loss. This will allow investigators to objectively view factors associated with weight loss without the confounding cognitive factors in humans.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner*in

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Jetzt e.Med zum Sonderpreis bestellen!
Das Angebot gilt nur bis 24.10.2021

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 10/2008

Obesity Surgery 10/2008 Zur Ausgabe
  1. Sie können e.Med Chirurgie 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.

Neu im Fachgebiet Chirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Chirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise