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Erschienen in: Clinical Journal of Gastroenterology 2/2015

01.04.2015 | Case Report

Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component

verfasst von: Emi Yamaguchi, Yoshitoshi Sato, Takafumi Oe, Takeshi Nishi, Makoto Koike, Yasuhito Kitakado, Kenji Takubo

Erschienen in: Clinical Journal of Gastroenterology | Ausgabe 2/2015

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Abstract

Small cell carcinoma of the stomach, which is considered synonymous with neuroendocrine carcinoma, is rare. We encountered a case of mixed adenoneuroendocrine carcinoma. Gastrointestinal endoscopy revealed a type 0 IIa + IIc lesion in the stomach. Biopsy suggested well-differentiated adenocarcinoma. Endoscopic submucosal dissection was performed and gastric cancer comprising both well to moderately differentiated adenocarcinoma within the mucous membrane and small cell carcinoma invading to the submucosa with accompanying vessel invasion was found. Mixed adenoneuroendocrine carcinoma was diagnosed and the small cell carcinoma was thyroid transcription factor-1 positive. No tumor lesions were apparent in other organs, so distal gastrectomy and lymph node dissection were performed. Lymph node metastases were not observed. The patient is currently alive without recurrence. Thyroid transcription factor-1-positive gastric neuroendocrine carcinoma is very rare, and the thyroid transcription factor-1-positive rate may contribute to the prediction of prognosis and treatment selection. Accumulation of cases is thus very important.
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Metadaten
Titel
Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component
verfasst von
Emi Yamaguchi
Yoshitoshi Sato
Takafumi Oe
Takeshi Nishi
Makoto Koike
Yasuhito Kitakado
Kenji Takubo
Publikationsdatum
01.04.2015
Verlag
Springer Japan
Erschienen in
Clinical Journal of Gastroenterology / Ausgabe 2/2015
Print ISSN: 1865-7257
Elektronische ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-015-0562-2

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