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Erschienen in: Digestive Diseases and Sciences 10/2017

23.08.2017 | Mentored Review

Gastrointestinal Manifestations of Hereditary Hemorrhagic Telangiectasia (HHT): A Systematic Review of the Literature

verfasst von: Samuel B. Jackson, Nicholas P. Villano, Jihane N. Benhammou, Michael Lewis, Joseph R. Pisegna, David Padua

Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2017

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Abstract

Hereditary hemorrhagic telangiectasia (HHT), also called Osler–Weber–Rendu syndrome, is an autosomal dominant genetic disease that affects the vasculature of numerous organs. The prevalence of HHT is estimated to be between 1.5 and 2 persons per 10,000. While there is still much to learn about this condition, there is an increasing understanding its underlying pathophysiology, genetic basis, presentations, and management. Recognizing that the clinical manifestations of HHT can involve a number of organ systems will provide clinicians with a higher index of suspicion for the disease. This early diagnosis and genotyping can greatly reduce mortality for a patient with HHT through appropriate screening for complications. This review will focus on the gastrointestinal manifestations of HHT and how these can dictate treatment and prognosis.
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Metadaten
Titel
Gastrointestinal Manifestations of Hereditary Hemorrhagic Telangiectasia (HHT): A Systematic Review of the Literature
verfasst von
Samuel B. Jackson
Nicholas P. Villano
Jihane N. Benhammou
Michael Lewis
Joseph R. Pisegna
David Padua
Publikationsdatum
23.08.2017
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 10/2017
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4719-3

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