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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Medical Genetics 1/2017

Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis

Zeitschrift:
BMC Medical Genetics > Ausgabe 1/2017
Autoren:
Tereza Cristina Pinheiro Diogenes, Felipe Alves Mourato, José Luiz de Lima Filho, Sandra da Silva Mattos
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12881-017-0475-7) contains supplementary material, which is available to authorized users.

Abstract

Background

Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them.

Methods

We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.

Results

Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.

Conclusion

CHD, particularly AVSD, are more common in the female gender of Down’s syndrome patients.
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