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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis

Zeitschrift:: BMC Medical Genetics > Ausgabe 1/2017

Autoren:: Tereza Cristina Pinheiro Diogenes, Felipe Alves Mourato, José Luiz de Lima Filho, Sandra da Silva Mattos

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Electronic supplementary material

The online version of this article (https://doi.org/10.1186/s12881-017-0475-7) contains supplementary material, which is available to authorized users.

Abstract

Background

Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them.

Methods

We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.

Results

Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.

Conclusion

CHD, particularly AVSD, are more common in the female gender of Down’s syndrome patients.

Additional file 1: Search strategy in Pubmed. Contains the terms and strategy to find the main articles of this meta-analysis in Pubmed. (DOC 51 kb)

Additional file 2: Raw data. Contains the raw data obtained from the articles for congenital heart disease and Down syndrome prevalence by gender. (DOCX 11 kb)

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Titel: Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
Autoren:: Tereza Cristina Pinheiro Diogenes
Felipe Alves Mourato
José Luiz de Lima Filho
Sandra da Silva Mattos
Publikationsdatum: 01.12.2017
DOI: https://doi.org/10.1186/s12881-017-0475-7
Verlag: BioMed Central
Zeitschrift: BMC Medical Genetics BMC series – open, inclusive and trusted
Ausgabe 1/2017
Elektronische ISSN: 1471-2350

Springer Medizin

Electronic supplementary material

Abstract

Background

Methods

Results

Conclusion

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