The online version of this article (doi:10.1186/1475-2840-11-106) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
DM and M Shimabukuro designed and conducted this study and drafted the manuscript; JU, ST, and MH assembled the application for multidetector computed tomography; TN contributed to patient management; DM, DF, YH, HK, TS, TI, KK, TN, KY, YT, SY, NT, HY, and TW measured EATV and participated in the analysis; TK and M Sata supervised the study. All authors read and approved the final manuscript.
Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis.
The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group.
EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia.
Increased EATV is strongly associated with coronary atherosclerosis in men.
Additional file 1: Characteristics of the study population after divided to <65 years or to ≥65 years. (PDF 51 KB)12933_2012_531_MOESM1_ESM.pdf
Additional file 2: Comparison of BMI (upper panel) and EAT/BSA (lower panel) in Non-CAD (○) and CAD (●)subjects with less or greater than 65 years of age. BMI, body mass index; EATV, epicardial adipose tissue volume; BSA, body surface area. Coronary artery disease (CAD) was defined if one has plaque lesion(s) causing greater than 50% luminal narrowing. Unpaired t test was made between Non-CAD and CAD subjects. p: P values. (TIFF 7 MB)12933_2012_531_MOESM2_ESM.tiff
Authors’ original file for figure 112933_2012_531_MOESM3_ESM.tiff
Authors’ original file for figure 212933_2012_531_MOESM4_ESM.tiff
Authors’ original file for figure 312933_2012_531_MOESM5_ESM.tiff
Authors’ original file for figure 412933_2012_531_MOESM6_ESM.tiff
Authors’ original file for figure 512933_2012_531_MOESM7_ESM.tiff
Authors’ original file for figure 612933_2012_531_MOESM8_ESM.tiff
Iacobellis G, Corradi D, Sharma AM: Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Prac Cardiovasc Med. 2005, 2: 536-543. 10.1038/ncpcardio0319. CrossRef
Sacks HS, Fain JN: Human epicardial adipose tissue: A review. Am Heart. 2007, 153: 907-917. 10.1016/j.ahj.2007.03.019. CrossRef
Kotani K, Tokunaga K, Fujioka S, et al: Sexual dimorphism of age-related changes in whole-body fat distribution in the obese. Int J Obes Relat Metab Disord. 1994, 18: 207-212. PubMed
Camhi SM, Bray GA, Bouchard C, et al: The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race difference. Obesity (Silver Spring). 2011, 19: 402-408. 10.1038/oby.2010.248. CrossRef
Gorter PM, van Lindert AS, de Vos AM, et al: Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease. Atherosclerosis. 2008, 197: 896-903. 10.1016/j.atherosclerosis.2007.08.016. CrossRefPubMed
Yerramasu A, Dey D, Venuraju S, Anand DV, Atwal S, Corder R, Berman DS, Lahiri A: Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis. Atherosclerosis. 2012, 220: 223-230. 10.1016/j.atherosclerosis.2011.09.041. CrossRefPubMed
Ding J, Kritchevsky SB, Harris TB, Burke GL, Detrano RC, Szklo M, Jeffrey Carr J: Multi-Ethnic Study of Atherosclerosis. The association of pericardial fat with calcified coronary plaque. Obesity (Silver Spring). 2008, 16: 1914-1919. 10.1038/oby.2008.278. CrossRef
Reqitz-Zaqrosek V, Lehmkuhl E, Weickert MO: Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol. 2006, 95: 136-147. 10.1007/s00392-006-0351-5. CrossRef
Park JS, Ahn SG, Hwang JW, Lim HS, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH: Impact of body mass index on the relationship of epicardial adipose tissue to metabolic syndrome and coronary artery disease in an Asian population. Cardiovasc Diabetol. 2010, 9: 29-10.1186/1475-2840-9-29. PubMedCentralCrossRefPubMed
Eroglu S, Sade LE, Yildirir A, Bal U, Ozbicer S, Ozgul AS, Bozbas H, Aydinalp A, Muderrisoglu H: Epicardial adipose tissue thickness by echocardiography is a marker for the presence and severity of coronary artery disease. Nutr Metab Cardiovasc Dis. 2009, 19: 211-217. 10.1016/j.numecd.2008.05.002. CrossRefPubMed
Kim HM, Kim KJ, Lee HJ, Yu HT, Moon JH, Kang ES, Cha BS, Lee HC, Lee BW, Kim YJ: Epicardial adipose tissue thickness is an indicator for coronary artery stenosis in asymptomatic type 2 diabetic patients: its assessment by cardiac magnetic resonance. Cardiovasc Diabetol. 2012, 11: 83-10.1186/1475-2840-11-83. PubMedCentralCrossRefPubMed
Shaw LJ, Bairey MCN, Pepine CJ, et al: Insights from the NHLBI-sponsored WISE study, part II: gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol. 2006, 47 (3 Suppl): S4-S20. CrossRefPubMed
Sade LE, Eroglu S, Bozbaş H, Ozbiçer S, Hayran M, Haberal A, Müderrisoğlu H: Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries. Atherosclerosis. 2009, 204: 580-585. 10.1016/j.atherosclerosis.2008.09.038. CrossRefPubMed
- Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II