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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Munkhbaatar Dagvasumberel, Michio Shimabukuro, Takeshi Nishiuchi, Junji Ueno, Shoichiro Takao, Daiju Fukuda, Yoichiro Hirata, Hirotsugu Kurobe, Takeshi Soeki, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Noriko Tomita, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masafumi Harada, Tetsuya Kitagawa, Masataka Sata
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-106) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

DM and M Shimabukuro designed and conducted this study and drafted the manuscript; JU, ST, and MH assembled the application for multidetector computed tomography; TN contributed to patient management; DM, DF, YH, HK, TS, TI, KK, TN, KY, YT, SY, NT, HY, and TW measured EATV and participated in the analysis; TK and M Sata supervised the study. All authors read and approved the final manuscript.

Abstract

Background

Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis.

Methods

The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group.

Results

EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia.

Conclusions

Increased EATV is strongly associated with coronary atherosclerosis in men.
Zusatzmaterial
Additional file 1: Characteristics of the study population after divided to <65 years or to ≥65 years. (PDF 51 KB)
12933_2012_531_MOESM1_ESM.pdf
Additional file 2: Comparison of BMI (upper panel) and EAT/BSA (lower panel) in Non-CAD (○) and CAD (●)subjects with less or greater than 65 years of age. BMI, body mass index; EATV, epicardial adipose tissue volume; BSA, body surface area. Coronary artery disease (CAD) was defined if one has plaque lesion(s) causing greater than 50% luminal narrowing. Unpaired t test was made between Non-CAD and CAD subjects. p: P values. (TIFF 7 MB)
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Authors’ original file for figure 1
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Authors’ original file for figure 2
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Authors’ original file for figure 3
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Authors’ original file for figure 4
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Authors’ original file for figure 5
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Authors’ original file for figure 6
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Literatur
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