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Erschienen in: Critical Care 2/2014

01.04.2014 | Letter

Gender-specific differences in outcome after trauma may be explained by differences in immunity

verfasst von: LucasT van Eijk, Matthijs Kox, Peter Pickkers

Erschienen in: Critical Care | Ausgabe 2/2014

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Excerpt

With great interest we read the article by Dr Schoeneberg and colleagues regarding gender-specific differences with respect to outcome in patients with severe traumatic injury. The authors show that, apart from the acute phase after trauma, women have a more favorable trauma severity-adjusted outcome, with shorter ICU and hospital stay and lower sepsis rates [1]. However, a possible mechanism of action behind this difference was not suggested. We hypothesize that, in view of the fact that morbidity and mortality in the post-acute phase after trauma are often caused by infectious complications [2], gender differences in immunity might explain the observed differences. …
Literatur
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Zurück zum Zitat Schoeneberg C, Kauther MD, Hussmann B, Keitel J, Schmitz D, Lendemans S: Gender-specific differences in severely injured patients between 2002 and 2011: data analysis with matched-pair analysis. Crit Care 2013, 17: R277. 10.1186/cc13132PubMedCentralCrossRefPubMed Schoeneberg C, Kauther MD, Hussmann B, Keitel J, Schmitz D, Lendemans S: Gender-specific differences in severely injured patients between 2002 and 2011: data analysis with matched-pair analysis. Crit Care 2013, 17: R277. 10.1186/cc13132PubMedCentralCrossRefPubMed
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Zurück zum Zitat Hietbrink F, Koenderman L, Rijkers G, Leenen L: Trauma: the role of the innate immune system. World J Emergency Surg 2006, 1: 15. 10.1186/1749-7922-1-15CrossRef Hietbrink F, Koenderman L, Rijkers G, Leenen L: Trauma: the role of the innate immune system. World J Emergency Surg 2006, 1: 15. 10.1186/1749-7922-1-15CrossRef
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Zurück zum Zitat van Eijk LT, Dorresteijn MJ, Smits P, van der Hoeven JG, Netea MG, Pickkers P: Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med 2007, 35: 1464-1469. 10.1097/01.CCM.0000266534.14262.E8CrossRefPubMed van Eijk LT, Dorresteijn MJ, Smits P, van der Hoeven JG, Netea MG, Pickkers P: Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med 2007, 35: 1464-1469. 10.1097/01.CCM.0000266534.14262.E8CrossRefPubMed
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Zurück zum Zitat Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P: Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med 2013, 187: 1287-1293. 10.1164/rccm.201301-0036CPCrossRefPubMed Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P: Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med 2013, 187: 1287-1293. 10.1164/rccm.201301-0036CPCrossRefPubMed
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Zurück zum Zitat Sperry JL, Nathens AB, Frankel HL, Vanek SL, Moore EE, Maier RV, Minei JP, Inflammation and the Host Response to Injury Investigators: Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? Crit Care Med 2008, 36: 1838-1845. 10.1097/CCM.0b013e3181760c14CrossRefPubMed Sperry JL, Nathens AB, Frankel HL, Vanek SL, Moore EE, Maier RV, Minei JP, Inflammation and the Host Response to Injury Investigators: Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? Crit Care Med 2008, 36: 1838-1845. 10.1097/CCM.0b013e3181760c14CrossRefPubMed
Metadaten
Titel
Gender-specific differences in outcome after trauma may be explained by differences in immunity
verfasst von
LucasT van Eijk
Matthijs Kox
Peter Pickkers
Publikationsdatum
01.04.2014
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 2/2014
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13768

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