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18.02.2019 | Hormonsubstitution | Schwerpunkt

Gastroösophageale Refluxerkrankung und geschlechtsspezifische Unterschiede

verfasst von: PD Dr. med. M. Selgrad, Prof. Dr. med. M. Müller-Schilling, PD Dr. med. A. Kandulski

Erschienen in: Die Gastroenterologie | Ausgabe 2/2019

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Zusammenfassung

Die gastroösophageale Refluxerkrankung (GERD) stellt eines der häufigsten gastroenterologischen Krankheitsbilder dar und zeigt einen deutlichen Anstieg der Prävalenz in den letzten Jahren. In der Krankheitsausprägung und -entstehung existieren geschlechtsspezifische Unterschiede, die differenziert betrachtet werden sollten. Männer haben eine stärkere Ausbildung der GERD in Hinblick auf den Grad der Entzündung und den Säurereflux. Wahrscheinlich ist aus diesem Grund das Risiko für die Entwicklung eines Barrett-Ösophagus bei Männern etwa 2‑ bis 3-fach und für ein ösophageales Adenokarzinom sogar 3‑ bis 6-mal höher als bei Frauen. Dies unterstreicht die Notwendigkeit, geschlechtsspezifische Unterschiede der GERD besser zu verstehen, um Diagnostik, Therapie und Prävention zu optimieren.

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Titel: Gastroösophageale Refluxerkrankung und geschlechtsspezifische Unterschiede
verfasst von: PD Dr. med. M. Selgrad
Prof. Dr. med. M. Müller-Schilling
PD Dr. med. A. Kandulski
Publikationsdatum: 18.02.2019
Verlag: Springer Medizin
Schlagwörter: Hormonsubstitution
Ösophaguskarzinom
Gastroösophageale Refluxkrankheit
Ösophaguskarzinom
Barrett-Ösophagus
Östrogene
Erschienen in: Die Gastroenterologie / Ausgabe 2/2019
Print ISSN: 2731-7420
Elektronische ISSN: 2731-7439
DOI: https://doi.org/10.1007/s11377-019-0322-9

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