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Pediatric Nephrology

Erschienen in:

01.07.2008 | Review

Gene discovery and vesicoureteric reflux

verfasst von: Inga J. Murawski, Indra R. Gupta

Erschienen in: Pediatric Nephrology | Ausgabe 7/2008

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Abstract

Vesicoureteric reflux (VUR) is a congenital urinary tract defect caused by abnormal insertion of the ureter within the bladder wall. This leads to a defective ureterovesical junction in which urine flows retrogradely from the bladder to the kidneys. Although VUR is associated with recurrent urinary tract infections, renal malformations, hypertension, and reflux nephropathy, its relationship to each of these clinical entities is poorly understood. Mutations in genes expressed by the developing kidney and urinary tract can cause VUR in mice, and some of these same genes have been identified in humans with VUR. By discovering the genes that are associated with VUR, new hypotheses will be generated such that, eventually, the relationship between VUR and its complications will be understood.

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Titel: Gene discovery and vesicoureteric reflux
verfasst von: Inga J. Murawski
Indra R. Gupta
Publikationsdatum: 01.07.2008
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 7/2008
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0704-y

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