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Breast Cancer Research

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01.06.2005 | Poster Presentation

Gene expression signature of hereditary breast cancer

verfasst von: V Dudaladava, M Jarzab, J Pamula, W Pekala, T Huzarski, J Lubinski, E Grzybowska, K Lisowska

Erschienen in: Breast Cancer Research | Sonderheft 2/2005

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Excerpt

Some clinical features of hereditary breast cancer, which develops in the presence of germline mutations in BRCA genes, are different from those of sporadic cases. Within recent years, better understanding of cancer biology and successful classification of tumors into distinct, clinically relevant subgroups were made possible by the methods of global gene expression analysis. Thus, we decided to compare gene expression profiles of hereditary versus sporadic breast cancer and possibly find the molecular basis underlying clinical observations. …

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Hedenfalk I, Duggan D, Chen Y, Radmasher M, Bittner M, Simon R, Meltzer P, Gusterson B, Esteller M, Kallioniemi OP, et al: Gene-expression profiles in hereditary breast cancer. N Engl J Med. 2001, 344: 539-548. 10.1056/NEJM200102223440801.CrossRefPubMed

Hedenfalk I, Ringner M, Ben-Dor A, Yakhini Z, Chen Y, Chebil G, Ach R, Loman N, Olsson H, Meltzer P, et al: Molecular classification of familial non-BRCA1/BRCA2 breast cancer. Proc Natl Acad Sci USA. 2003, 100: 2532-2537. 10.1073/pnas.0533805100.CrossRefPubMedPubMedCentral

Titel: Gene expression signature of hereditary breast cancer
verfasst von: V Dudaladava
M Jarzab
J Pamula
W Pekala
T Huzarski
J Lubinski
E Grzybowska
K Lisowska
Publikationsdatum: 01.06.2005
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 2/2005
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1160

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