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Erschienen in: Breast Cancer Research 2/2011

01.12.2011 | Oral presentation

Gene pathways associated with prognosis and chemotherapy sensitivity in different molecular subtypes of breast cancer

verfasst von: L Pusztai

Erschienen in: Breast Cancer Research | Sonderheft 2/2011

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Excerpt

Breast cancer consists of multiple different molecular subtypes and different biological processes, and consequently different molecular markers are associated with prognosis and chemotherapy sensitivity in the distinct disease subsets [1]. A large number of biological processes including cell cycle regulation, DNA replication, mitotic spindle checkpoint, and p53 function are strongly prognostic in ER+ cancers but not among ER- cancers [2, 3]. Interestingly, the number of biological pathways, and therefore genes, that are associated with prognosis or treatment sensitivity are substantially larger and more consistent in ER+ cancers than among ER- tumors [1, 4]. This implies that it is easier to discover prognostic and predictive markers for ER+ than for ER- cancers. In ER- cancers, the single most consistent, but still modestly accurate, good prognostic predictor is the presence of immune cell infiltration [5]. Immune cell signatures are also associated with more favorable prognosis in highly proliferative ER+ cancers but not in ER+ cancers with low proliferation [6]. …
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Metadaten
Titel
Gene pathways associated with prognosis and chemotherapy sensitivity in different molecular subtypes of breast cancer
verfasst von
L Pusztai
Publikationsdatum
01.12.2011
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2011
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3000

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