Erschienen in:
01.12.2011 | Oral presentation
Gene pathways associated with prognosis and chemotherapy sensitivity in different molecular subtypes of breast cancer
verfasst von:
L Pusztai
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2011
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Excerpt
Breast cancer consists of multiple different molecular subtypes and different biological processes, and consequently different molecular markers are associated with prognosis and chemotherapy sensitivity in the distinct disease subsets [
1]. A large number of biological processes including cell cycle regulation, DNA replication, mitotic spindle checkpoint, and p53 function are strongly prognostic in ER
+ cancers but not among ER
- cancers [
2,
3]. Interestingly, the number of biological pathways, and therefore genes, that are associated with prognosis or treatment sensitivity are substantially larger and more consistent in ER
+ cancers than among ER
- tumors [
1,
4]. This implies that it is easier to discover prognostic and predictive markers for ER
+ than for ER
- cancers. In ER
- cancers, the single most consistent, but still modestly accurate, good prognostic predictor is the presence of immune cell infiltration [
5]. Immune cell signatures are also associated with more favorable prognosis in highly proliferative ER
+ cancers but not in ER
+ cancers with low proliferation [
6]. …