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02.08.2018 | Brief Report

Genetic characterization of chikungunya viruses isolated during the 2015-2017 outbreaks in different states of India, based on their E1 and E2 genes

verfasst von: Jayashri Patil, Ashwini More, Poonam Patil, Santosh Jadhav, Priyanka Newase, Megha Agarwal, Sarika Amdekar, C. G. Raut, Deepti Parashar, Sarah S. Cherian

Erschienen in: Archives of Virology | Ausgabe 11/2018

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Abstract

During 2015-2017, chikungunya virus (CHIKV) showed a resurgence in several parts of India with Karnataka, Maharashtra and New Delhi accounting for a majority of the cases. E2-E1 gene based characterization revealed Indian subcontinent sublineage strains possessing Aedes aegypti mosquito-adaptive mutations E1: K211E and E2:V264A, with the 211 site positively selected. Novel mutational sites E1: K16E/Q, E1: K132Q/T, E1: S355T, E2: C19R and E2:S185Y could be associated with epitopes or virulence determining domains. The study examines the role of host, vector and viral factors and fills gaps in our molecular epidemiology data for these regions which are known to possess a dynamic population.

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Titel: Genetic characterization of chikungunya viruses isolated during the 2015-2017 outbreaks in different states of India, based on their E1 and E2 genes
verfasst von: Jayashri Patil
Ashwini More
Poonam Patil
Santosh Jadhav
Priyanka Newase
Megha Agarwal
Sarika Amdekar
C. G. Raut
Deepti Parashar
Sarah S. Cherian
Publikationsdatum: 02.08.2018
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 11/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-018-3974-8

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Genetic characterization of chikungunya viruses isolated during the 2015-2017 outbreaks in different states of India, based on their E1 and E2 genes

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