nach oben

Journal of NeuroVirology

Erschienen in:

05.10.2018

Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada

verfasst von: K. Pabbaraju, K. Fonseca, S. Wong, M. W. Koch, J. T. Joseph, G. A. Tipples, R. Tellier

Erschienen in: Journal of NeuroVirology | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive and eventually fatal neurological disease arising from a persistent infection with measles virus (MV) acquired at a young age. SSPE measles virus strains are defective and unable to produce progeny virions, due to multiple and extensive mutations in a number of key genes. We sequenced the full MV genome from our recently reported SSPE case, which typed as genotype D6, and compared it with other genotype D6 wild type and SSPE sequences. The Alberta D6 strain was significantly different from other reported SSPE D6 sequences. Mutations were observed in all the genes of the Alberta strain, with the greatest sequence divergence noted in the M gene with 17.6% nucleotide and 31% amino acid variation. The L gene showed the least variation with 1.3% nucleotide and 0.7% amino acid differences respectively. The nucleotide variability for 15,672 bases of the complete genome compared to the wild type and other SSPE D6 strains was around 3%.

Ayata M, Hirano A, Wong TC (1989) Structural defect linked to nonrandom mutations in the matrix gene of biken strain subacute sclerosing panencephalitis virus defined by cDNA cloning and expression of chimeric genes. J Virol 63(3):1162–1173PubMedPubMedCentral

Ayata M, Komase K, Shingai M, Matsunaga I, Katayama Y, Ogura H (2002) Mutations affecting transcriptional termination in the p gene end of subacute sclerosing panencephalitis viruses. J Virol 76(24):13062–13068CrossRefPubMedPubMedCentral

Ayata M, Takeuchi K, Takeda M, Ohgimoto S, Kato S, Sharma LB, Tanaka M, Kuwamura M, Ishida H, Ogura H (2010) The F gene of the Osaka-2 strain of measles virus derived from a case of subacute sclerosing panencephalitis is a major determinant of neurovirulence. J Virol 84(21):11189–11199CrossRefPubMedPubMedCentral

Baczko K, Liebert UG, Billeter M, Cattaneo R, Budka H, ter Meulen V (1986) Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis. J Virol 59(2):472–478PubMedPubMedCentral

Bankamp B, Wilson J, Bellini WJ, Rota PA (2005) Identification of naturally occurring amino acid variations that affect the ability of the measles virus C protein to regulate genome replication and transcription. Virology 336(1):120–129CrossRefPubMed

Baricevic M, Forcic D, Santak M, Mazuran R (2007) A comparison of complete untranslated regions of measles virus genomes derived from wild-type viruses and SSPE brain tissues. Virus Genes 35(1):17–27CrossRefPubMed

Bass BL, Weintraub H, Cattaneo R, Billeter MA (1989) Biased hypermutation of viral RNA genomes could be due to unwinding/modification of double-stranded RNA. Cell 56(3):331CrossRefPubMed

Bellini WJ, Rota JS, Lowe LE, Katz RS, Dyken PR, Zaki SR, Shieh WJ, Rota PA (2005) Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized. J Infect Dis 192(10):1686–1693CrossRefPubMed

Billeter MA, Cattaneo R (1991) Molecular biology of defective measles virus persisting in the human central nervous system. Plenum Press, New York

Cathomen T, Mrkic B, Spehner D, Drillien R, Naef R, Pavlovic J, Aguzzi A, Billeter MA, Cattaneo R (1998a) A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain. EMBO J 17(14):3899–3908CrossRefPubMedPubMedCentral

Cathomen T, Naim HY, Cattaneo R (1998b) Measles viruses with altered envelope protein cytoplasmic tails gain cell fusion competence. J Virol 72(2):1224–1234PubMedPubMedCentral

Cattaneo R, Schmid A, Rebmann G, Baczko K, Ter Meulen V, Bellini WJ, Rozenblatt S, Billeter MA (1986) Accumulated measles virus mutations in a case of subacute sclerosing panencephalitis: interrupted matrix protein reading frame and transcription alteration. Virology 154(1):97–107CrossRefPubMed

Cattaneo R, Schmid A, Billeter MA, Sheppard RD, Udem SA (1988a) Multiple viral mutations rather than host factors cause defective measles virus gene expression in a subacute sclerosing panencephalitis cell line. J Virol 62(4):1388–1397PubMedPubMedCentral

Cattaneo R, Schmid A, Eschle D, Baczko K, ter Meulen V, Billeter MA (1988b) Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell 55(2):255–265CrossRefPubMedPubMedCentral

Cattaneo R, Schmid A, Spielhofer P, Kaelin K, Baczko K, ter Meulen V, Pardowitz J, Flanagan S, Rima BK, Udem SA, Billeter MA (1989) Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Virology 173(2):415–425CrossRefPubMed

Chiu MH, Meatherall B, Nikolic A, Cannon K, Fonseca K, Joseph JT, MacDonald J, Pabbaraju K, Tellier R, Wong S, Koch MW (2016) Subacute sclerosing panencephalitis in pregnancy. Lancet Infect Dis 16(3):366–375CrossRefPubMedPubMedCentral

Forcic D, Baricevic M, Zgorelec R, Kruzic V, Kaic B, Marina BM, Sojat LC, Tesovic G, Mazuran R (2004) Detection and characterization of measles virus strains in cases of subacute sclerosing panencephalitis in Croatia. Virus Res 99(1):51–56CrossRefPubMed

Garg RK (2008) Subacute sclerosing panencephalitis. J Neurol 255(12):1861–1871CrossRefPubMed

Griffin DE (2007) Fields virology. Lippincott Williams and Wilkins, Philadelphia

Hotta H, Nihei K, Abe Y, Kato S, Jiang DP, Nagano-Fujii M, Sada K (2006) Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE. Microbiol Immunol 50(7):525–534CrossRefPubMed

Hummel KB, Lowe L, Bellini WJ, Rota PA (2006) Development of quantitative gene-specific real-time RT-PCR assays for the detection of measles virus in clinical specimens. J Virol Methods 132(1–2):166–173CrossRefPubMed

Jiang DP, Ide YH, Nagano-Fujii M, Shoji I, Hotta H (2009) Single-point mutations of the M protein of a measles virus variant obtained from a patient with subacute sclerosing panencephalitis critically affect solubility and subcellular localization of the M protein and cell-free virus production. Microbes Infect 11(4):467–475CrossRefPubMed

Jin L, Beard S, Hunjan R, Brown DW, Miller E (2002) Characterization of measles virus strains causing SSPE: a study of 11 cases. J Neuro-Oncol 8(4):335–344

Karlin D, Longhi S, Canard B (2002) Substitution of two residues in the measles virus nucleoprotein results in an impaired self-association. Virology 302(2):420–432CrossRefPubMed

Kweder H, Ainouze M, Cosby SL, Muller CP, Levy C, Verhoeyen E, Cosset FL, Manet E, Buckland R (2014) Mutations in the H, F, or M proteins can facilitate resistance of measles virus to neutralizing human anti-MV sera. Adv Virol 2014:205617CrossRefPubMedPubMedCentral

Moll M, Klenk HD, Maisner A (2002) Importance of the cytoplasmic tails of the measles virus glycoproteins for fusogenic activity and the generation of recombinant measles viruses. J Virol 76(14):7174–7186CrossRefPubMedPubMedCentral

Moulin E, Beal V, Jeantet D, Horvat B, Wild TF, Waku-Kouomou D (2011) Molecular characterization of measles virus strains causing subacute sclerosing panencephalitis in France in 1977 and 2007. J Med Virol 83(9):1614–1623CrossRefPubMed

Ning X, Ayata M, Kimura M, Komase K, Furukawa K, Seto T, Ito N, Shingai M, Matsunaga I, Yamano T, Ogura H (2002) Alterations and diversity in the cytoplasmic tail of the fusion protein of subacute sclerosing panencephalitis virus strains isolated in Osaka, Japan. Virus Res 86(1–2):123–131CrossRefPubMed

Parks CL, Lerch RA, Walpita P, Wang HP, Sidhu MS, Udem SA (2001) Analysis of the noncoding regions of measles virus strains in the Edmonston vaccine lineage. J Virol 75(2):921–933CrossRefPubMedPubMedCentral

Patterson JB, Samuel CE (1995) Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Mol Cell Biol 15(10):5376–5388CrossRefPubMedPubMedCentral

Patterson JB, Cornu TI, Redwine J, Dales S, Lewicki H, Holz A, Thomas D, Billeter MA, Oldstone MB (2001) Evidence that the hypermutated M protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive CNS disease. Virology 291(2):215–225CrossRefPubMed

Rima BK, Duprex WP (2005) Molecular mechanisms of measles virus persistence. Virus Res 111(2):132–147CrossRefPubMed

Rota PA, Liffick SL, Rota JS, Katz RS, Redd S, Papania M, Bellini WJ (2002) Molecular epidemiology of measles viruses in the United States, 1997–2001. Emerg Infect Dis 8(9):902–908CrossRefPubMedPubMedCentral

Rota PA, Brown K, Mankertz A, Santibanez S, Shulga S, Muller CP, Hubschen JM, Siqueira M, Beirnes J, Ahmed H, Triki H, Al-Busaidy S, Dosseh A, Byabamazima C, Smit S, Akoua-Koffi C, Bwogi J, Bukenya H, Wairagkar N, Ramamurty N, Incomserb P, Pattamadilok S, Jee Y, Lim W, Xu W, Komase K, Takeda M, Tran T, Castillo-Solorzano C, Chenoweth P, Brown D, Mulders MN, Bellini WJ, Featherstone D (2011) Global distribution of measles genotypes and measles molecular epidemiology. J Infect Dis 204(Suppl 1):S514–S523CrossRefPubMed

Runkler N, Pohl C, Schneider-Schaulies S, Klenk HD, Maisner A (2007) Measles virus nucleocapsid transport to the plasma membrane requires stable expression and surface accumulation of the viral matrix protein. Cell Microbiol 9(5):1203–1214CrossRefPubMed

Santak M, Baricevic M, Mazuran R, Forcic D (2007) Intra- and intergenotype characterization of D6 measles virus genotype. Infect Genet Evol 7(5):645–650CrossRefPubMed

Schmid A, Spielhofer P, Cattaneo R, Baczko K, ter Meulen V, Billeter MA (1992) Subacute sclerosing panencephalitis is typically characterized by alterations in the fusion protein cytoplasmic domain of the persisting measles virus. Virology 188(2):910–915CrossRefPubMed

Sharma V, Gupta VB, Eisenhut M (2008) Familial subacute sclerosing panencephalitis associated with short latency. Pediatr Neurol 38(3):215–217CrossRefPubMed

Sheppard RD, Raine CS, Bornstein MB, Udem SA (1986) Rapid degradation restricts measles virus matrix protein expression in a subacute sclerosing panencephalitis cell line. Proc Natl Acad Sci U S A 83(20):7913–7917CrossRefPubMedPubMedCentral

Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 30(12):2725–2729CrossRefPubMedPubMedCentral

Tipples G, Gray A, Garbutt M, Rota PA, Canadian Measles Surveillance Program (2004) Genotyping of measles virus in Canada: 1979–2002. J Infect Dis 189(Suppl 1):S171–S176CrossRefPubMed

Vieker S, Schmitt JJ, Behrens C, Weissbrich B, Hartmann H (2003) Subacute sclerosing panencephalitis in two brothers. Neuropediatrics 34(6):326–329CrossRefPubMed

Watanabe M, Wang A, Sheng J, Gombart AF, Ayata M, Ueda S, Hirano A, Wong TC (1995) Delayed activation of altered fusion glycoprotein in a chronic measles virus variant that causes subacute sclerosing panencephalitis. J Neuro-Oncol 1(5–6):412–423

Wendorf KA, Winter K, Zipprich J, Schechter R, Hacker JK, Preas C, Cherry JD, Glaser C, Harriman K (2017) Subacute sclerosing panencephalitis: the devastating measles complication that might be more common than previously estimated. Clin Infect Dis 65(2):226–232CrossRefPubMed

WHO (2012) Measles virus nomenclature update: 2012. Wkly Epidemiol Rec 87(9):73–81

Wong TC, Ayata M, Hirano A, Yoshikawa Y, Tsuruoka H, Yamanouchi K (1989) Generalized and localized biased hypermutation affecting the matrix gene of a measles virus strain that causes subacute sclerosing panencephalitis. J Virol 63(12):5464–5468PubMedPubMedCentral

Yilmaz D, Aydin OF, Senbil N, Yuksel D (2006) Subacute sclerosing panencephalitis: is there something different in the younger children? Brain Dev 28(10):649–652CrossRefPubMed

Titel: Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada
verfasst von: K. Pabbaraju
K. Fonseca
S. Wong
M. W. Koch
J. T. Joseph
G. A. Tipples
R. Tellier
Publikationsdatum: 05.10.2018
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 6/2018
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0668-7

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

23.04.2024 | Demenz | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2018

2018 Colorado Alphaherpesvirus Latency Society Symposium

Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium

Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses

Screening for viral nucleic acids in vestibular schwannoma

Contribution of quantitative viral markers to document hepatitis B virus compartmentalization in cerebrospinal fluid during hepatitis B with neuropathies

Peripheral and cerebrospinal fluid immune activation and inflammation in chronically HIV-infected patients before and after virally suppressive combination antiretroviral therapy (cART)

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie