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Erschienen in: Osteoporosis International 5/2003

01.09.2003 | Original Article

Genetic determinants of bone strength and fracture in humans: dreams and realities

verfasst von: Sergio Livio Ferrari

Erschienen in: Osteoporosis International | Sonderheft 5/2003

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Excerpt

Why search for gene variants underlying susceptibility to osteoporosis? First, because we hope to improve identification of individuals predisposed to fractures. Indeed, areal bone mineral density (aBMD), as assessed by dual-energy X-ray absorptiometry (DXA), has proven a valuable tool to identify subjects at greatest risk for osteoporotic fractures (high incidence rate among those with T-score below −2.5), but the vast majority of fractures (true incidence) actually occurs among those individuals whose aBMD is above the diagnostic threshold [1]. Second, because we would like to predict individual responses to therapeutic interventions in order to design targeted prevention strategies (pharmacogenetics and nutrigenetics). Third, we may gain new insights into the pathophysiology and treatment of osteoporosis. …
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Metadaten
Titel
Genetic determinants of bone strength and fracture in humans: dreams and realities
verfasst von
Sergio Livio Ferrari
Publikationsdatum
01.09.2003
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe Sonderheft 5/2003
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1481-5

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