Skip to main content
main-content

26.01.2017 | Craniofacial Skeleton (G Roberts, Section Editor) | Ausgabe 1/2017

Current Osteoporosis Reports 1/2017

Genetic Disorders of Dental Development: Tales from the Bony Crypt

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 1/2017
Autoren:
Sylvia A. Frazier-Bowers, Siddharth R. Vora
Wichtige Hinweise
This article is part of the Topical Collection on Craniofacial Skeleton

Abstract

Purpose of Review

The ebb and flow of genetic influence relative to the understanding of craniofacial and dental disorders has evolved into a tacit acceptance of the current genetic paradigm. This review explores the science behind craniofacial and dental disorders through the lens of recent past and current findings and using tooth agenesis as a model of advances in craniofacial genetics.

Recent Findings

Contemporary studies of craniofacial biology takes advantage of the technological resources stemming from the genomic and post-genomic eras. Emerging data highlights the role of key genes and the epigenetic landscape controlling these genes, in causing dentofacial abnormalities. We also report here a novel Glu78FS MSX1 mutation in one family segregating an autosomal dominant form of severe tooth agenesis as an illustration of an evolving theme, i.e., different mutations in the same gene can result in a spectrum of dentofacial phenotypic severity.

Summary

The future of clinical therapeutics will benefit from advances in genetics and molecular biology that refine the genotype-phenotype correlation. Indeed, the past century suggests a continued convergence of genetic science in the practice of clinical dentistry.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Current Osteoporosis Reports 1/2017 Zur Ausgabe

Bone and Diabetes (A Schwartz and P Vestergaard, section editors)

Is Diabetic Skeletal Fragility Associated with Microvascular Complications in Bone?

Skeletal Development (P Trainor and K Svoboda, Section Editors)

Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling

Kidney and Bone (S Moe and I Salusky, Section Editors)

The Role of TGFβ in Bone-Muscle Crosstalk

Biomechanics (M Silva and K Jepsen, Section Editors)

Clinical Evaluation of Bone Strength and Fracture Risk

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise