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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.02.2010

Genetic Insights into Congenital Neutropenia

verfasst von: Christoph Klein, Karl Welte

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 1/2010

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Abstract

Congenital neutropenia syndromes comprise a heterogeneous group of disorders leading to increased susceptibility to bacterial infections. Recent work has elucidated the molecular basis of several congenital neutropenia syndromes such as mutations in ELA2, HAX1, GF11, and WAS. In addition, a number of complex clinical syndromes associating congenital neutropenia have been recognized and elucidated on a genetic level, e.g. p14-deficiency or G6PC3-deficiency. The clinical and genetic findings of various neutropenia syndromes are being discussed.

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Titel: Genetic Insights into Congenital Neutropenia
verfasst von: Christoph Klein
Karl Welte
Publikationsdatum: 01.02.2010
Verlag: Humana Press Inc
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 1/2010
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-009-8130-5

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