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Erschienen in: Rechtsmedizin 5/2023

10.07.2023 | Original reports

Genetic portrait of 23 Y-STR loci in the Brahmin population of Haryana, India

verfasst von: Shivkant Sharma, Ritu Yadav, Vivek Sahajpal, Martin Zieger, Shalu Ranga, Parul Ahuja, Chetna Yadav, Mukesh Tanwar, Lokesh Kadian, Preeti Chauhan

Erschienen in: Rechtsmedizin | Ausgabe 5/2023

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Abstract

In India, there is a lack of Y‑STR haplotype data of different castes/groups. In this direction, we have conducted the present study for the first time to generate the Y‑STR haplotype data of Haryana Brahmin population. Forensic application and genetic diversity of the Brahmin population of Haryana (India) were studied using 23 Y-STR markers in 104 male individuals. Several forensic parameters such as haplotype diversity (HD), allelic and haplotype frequency, discrimination power (PD), polymorphism information content (PIC) and random match probability (PM) were assessed for this population. Pairwise Rst values were also evaluated by analyzing AMOVA and envisioned through multidimensional scaling (MDS) plot. The average discrimination capacity (DC), HD and gene diversity (GD) values of the panel were found to be 0.9696, 0.999 and 0.654, respectively. Overall, 99 complete haplotype profiles were generated in 104 individuals of whom 93 were unique and three haplotypes were found twice. DYS576 and DYS481 markers showed the presence of micro-variant alleles. Our results conclude that 23 Y-STRs loci in the Brahmins of Haryana are forensically potent and might contribute to our understanding of the genealogical relationship between Brahmin and other Indian populations. In addition, generated genetic data of the Brahmin population of Haryana will enrich the population data bank.
Literatur
3.
Zurück zum Zitat Aliferi A, Thomson J, McDonald A, Paynter VM, Ferguson S, Vanhinsbergh D, Syndercombe Court D, Ballard D (2018) UK and Irish Y‑STR population data—A catalogue of variant alleles. Forensic Sci Int Genet 34:e1–e6 CrossRefPubMed Aliferi A, Thomson J, McDonald A, Paynter VM, Ferguson S, Vanhinsbergh D, Syndercombe Court D, Ballard D (2018) UK and Irish Y‑STR population data—A catalogue of variant alleles. Forensic Sci Int Genet 34:e1–e6 CrossRefPubMed
5.
Zurück zum Zitat Athey TW (2006) Haplogroup prediction from Y‑STR values using a Bayesian-allele frequency approach. J Genet Geneal 2:34–39 Athey TW (2006) Haplogroup prediction from Y‑STR values using a Bayesian-allele frequency approach. J Genet Geneal 2:34–39
6.
Zurück zum Zitat Bhatnagar S, Agrawal S (2002) Surname endogamy among the Brahmin of India. Curr Sociol 50(6):853–861 CrossRef Bhatnagar S, Agrawal S (2002) Surname endogamy among the Brahmin of India. Curr Sociol 50(6):853–861 CrossRef
8.
Zurück zum Zitat Frank WE, Ralph HC, Tahir MA (2008) Y chromosome STR haplotypes and allele frequencies in a Southern Indian male population. J Forensic Sci 53(1):248–251 CrossRefPubMed Frank WE, Ralph HC, Tahir MA (2008) Y chromosome STR haplotypes and allele frequencies in a Southern Indian male population. J Forensic Sci 53(1):248–251 CrossRefPubMed
9.
Zurück zum Zitat Ghosh T, Kalpana D, Mukerjee S, Mukherjee M, Sharma AK, Nath S, Rathod VR, Thakar MK, Jha GN (2010) Genetic diversity of 17 Y‑short tandem repeats in Indian population. Forensic Sci Int Genet 5(4):363–367 CrossRef Ghosh T, Kalpana D, Mukerjee S, Mukherjee M, Sharma AK, Nath S, Rathod VR, Thakar MK, Jha GN (2010) Genetic diversity of 17 Y‑short tandem repeats in Indian population. Forensic Sci Int Genet 5(4):363–367 CrossRef
10.
Zurück zum Zitat Gouy A, Zieger M (2017) STRAF—A convenient online tool for STR data evaluation in forensic genetics. Forensic Sci Int Genet 30:148–151 CrossRefPubMed Gouy A, Zieger M (2017) STRAF—A convenient online tool for STR data evaluation in forensic genetics. Forensic Sci Int Genet 30:148–151 CrossRefPubMed
11.
Zurück zum Zitat Imam J, Reyaz R, Singh RS, Bapuly AK, Shrivastava P (2018) Genomic portrait of population of Jharkhand, India, drawn with 15 autosomal STRs and 17 Y‑STRs. Int J Legal Med 132(1):139–140 CrossRefPubMed Imam J, Reyaz R, Singh RS, Bapuly AK, Shrivastava P (2018) Genomic portrait of population of Jharkhand, India, drawn with 15 autosomal STRs and 17 Y‑STRs. Int J Legal Med 132(1):139–140 CrossRefPubMed
12.
Zurück zum Zitat Jain T, Shrivastava P, Trivedi VB (2017) Genetic portrait of Majhi tribe of Chhattisgarh, India based on 15 autosomal STRs and 23 Y‑STRs. Int J Legal Med 131(1):113–114 CrossRefPubMed Jain T, Shrivastava P, Trivedi VB (2017) Genetic portrait of Majhi tribe of Chhattisgarh, India based on 15 autosomal STRs and 23 Y‑STRs. Int J Legal Med 131(1):113–114 CrossRefPubMed
13.
Zurück zum Zitat Joshi B, Lemtur S, Humtsoe M, Verma K, Kumawat RK, Kushwaha P, Kumar A, Srivastav KVV, Srivastava A, Shrivastava P (2022) Genetic portrait of 23 Y‑STR loci in the Naga tribes of Nagaland, India. Int J Legal Med 136(2):559–560 CrossRefPubMed Joshi B, Lemtur S, Humtsoe M, Verma K, Kumawat RK, Kushwaha P, Kumar A, Srivastav KVV, Srivastava A, Shrivastava P (2022) Genetic portrait of 23 Y‑STR loci in the Naga tribes of Nagaland, India. Int J Legal Med 136(2):559–560 CrossRefPubMed
14.
Zurück zum Zitat Kumar A, Kumar R, Kumawat RK, Mathur B, Shrivastava P, Chaubey G, Yadav RK (2020) Genetic portrait study for 23 Y‑STR loci in the population of Rajasthan, India. Int J Legal Med 134(5):1691–1693 CrossRefPubMed Kumar A, Kumar R, Kumawat RK, Mathur B, Shrivastava P, Chaubey G, Yadav RK (2020) Genetic portrait study for 23 Y‑STR loci in the population of Rajasthan, India. Int J Legal Med 134(5):1691–1693 CrossRefPubMed
15.
Zurück zum Zitat Kumawat RK, Shrivastava P, Shrivastava D, Mathur GK (2020) Molecular diversity of 23 Y‑STR genetic markers in the population of Rajasthan, India. Meta Gene 24:100694 CrossRef Kumawat RK, Shrivastava P, Shrivastava D, Mathur GK (2020) Molecular diversity of 23 Y‑STR genetic markers in the population of Rajasthan, India. Meta Gene 24:100694 CrossRef
16.
Zurück zum Zitat Mahal DG (2021) Y‑DNA genetic evidence reveals several different ancient origins in the Brahmin population. Mol Genet Genomics 296(1):67–78 CrossRefPubMed Mahal DG (2021) Y‑DNA genetic evidence reveals several different ancient origins in the Brahmin population. Mol Genet Genomics 296(1):67–78 CrossRefPubMed
18.
Zurück zum Zitat Mohapatra BK, Chauhan K, Shrivastava P, Sharma A, Dagar S, Kaitholia K (2019) Haplotype data for 17 Y‑STR loci in the population of Himachal Pradesh, India. Int J Legal Med 133:1401–1402 CrossRefPubMed Mohapatra BK, Chauhan K, Shrivastava P, Sharma A, Dagar S, Kaitholia K (2019) Haplotype data for 17 Y‑STR loci in the population of Himachal Pradesh, India. Int J Legal Med 133:1401–1402 CrossRefPubMed
22.
Zurück zum Zitat Peakall R, Smouse PE (2006) GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research. Bioinformatics 6(1):288–295 Peakall R, Smouse PE (2006) GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research. Bioinformatics 6(1):288–295
23.
Zurück zum Zitat Perez-Benedico D, Chennakrishnaiah S, Gayden T, Rowold DJ, Garcia-Bertrand R, Herrera RJ (2016) Y‑STR markers from Ladakh in the Himalayas. Leg Med 21:29–32 CrossRef Perez-Benedico D, Chennakrishnaiah S, Gayden T, Rowold DJ, Garcia-Bertrand R, Herrera RJ (2016) Y‑STR markers from Ladakh in the Himalayas. Leg Med 21:29–32 CrossRef
24.
Zurück zum Zitat Reddy B, Mohan VM, Naidu V (2005) Microsatellite diversity in Andhra Pradesh, India: genetic stratification versus social stratification. Hum Biol 77(6):803–823 CrossRefPubMed Reddy B, Mohan VM, Naidu V (2005) Microsatellite diversity in Andhra Pradesh, India: genetic stratification versus social stratification. Hum Biol 77(6):803–823 CrossRefPubMed
25.
Zurück zum Zitat Reid KM, Heathfield LJ (2020) Allele frequency data for 23 Y‑chromosome short tandem repeats (STRs) for the South African population. Forensic Sci Int Genet 46:102270 CrossRefPubMed Reid KM, Heathfield LJ (2020) Allele frequency data for 23 Y‑chromosome short tandem repeats (STRs) for the South African population. Forensic Sci Int Genet 46:102270 CrossRefPubMed
26.
Zurück zum Zitat Sahajpal V, Rajput S, Sharma T, Sharma A, Thakar MK (2019) Development and evaluation of a novel DNA purification buffer and protocol for blood samples on FTA cards. Forensic Sci Int Reports 1:100014 CrossRef Sahajpal V, Rajput S, Sharma T, Sharma A, Thakar MK (2019) Development and evaluation of a novel DNA purification buffer and protocol for blood samples on FTA cards. Forensic Sci Int Reports 1:100014 CrossRef
27.
Zurück zum Zitat Sahoo S, Kashyap VK (2006) Phylogeography of mitochondrial DNA and Y‑chromosome haplogroups reveal asymmetric gene flow in populations of Eastern India. Am J Phys Anthropol 131(1):84–97 CrossRefPubMed Sahoo S, Kashyap VK (2006) Phylogeography of mitochondrial DNA and Y‑chromosome haplogroups reveal asymmetric gene flow in populations of Eastern India. Am J Phys Anthropol 131(1):84–97 CrossRefPubMed
28.
Zurück zum Zitat Sharma S, Rai E, Sharma P, Jena M, Singh S, Darvishi K, Bhat AK, Bhanver A, Tiwari PK, Bamezai RN (2009) The Indian origin of paternal haplogroup R1a1* substantiates the autochthonous origin of Brahmins and the caste system. J Hum Genet 54(1):47–55 CrossRefPubMed Sharma S, Rai E, Sharma P, Jena M, Singh S, Darvishi K, Bhat AK, Bhanver A, Tiwari PK, Bamezai RN (2009) The Indian origin of paternal haplogroup R1a1* substantiates the autochthonous origin of Brahmins and the caste system. J Hum Genet 54(1):47–55 CrossRefPubMed
29.
Zurück zum Zitat Sharma S, Yadav R, Sahajpal V, Kumari L, Sharma A (2022) A comparative study on the frequency of Amelogenin Y deletion in a Brahmin population of Haryana and Rajasthan state with other Indian and global populations. Russ J Genet 58(3):359–364 CrossRef Sharma S, Yadav R, Sahajpal V, Kumari L, Sharma A (2022) A comparative study on the frequency of Amelogenin Y deletion in a Brahmin population of Haryana and Rajasthan state with other Indian and global populations. Russ J Genet 58(3):359–364 CrossRef
30.
Zurück zum Zitat Sharma S, Yadav R, Sahajpal V, Singh M, Ranga S, Kadian L, Yadav C, Patial A, Devi N, Ahuja P (2022) Y‑23 mediated genetic data analysis of endogamous Brahmin population of Rajasthan, India. Data Brief 42:108061 CrossRefPubMedPubMedCentral Sharma S, Yadav R, Sahajpal V, Singh M, Ranga S, Kadian L, Yadav C, Patial A, Devi N, Ahuja P (2022) Y‑23 mediated genetic data analysis of endogamous Brahmin population of Rajasthan, India. Data Brief 42:108061 CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Shrivastava P, Jain T, Trivedi VB (2016) Haplotype data for 17 Y‑STR loci in the population of Madhya Pradesh, India. Forensic Sci Int Genet 26:e31–e32 CrossRefPubMed Shrivastava P, Jain T, Trivedi VB (2016) Haplotype data for 17 Y‑STR loci in the population of Madhya Pradesh, India. Forensic Sci Int Genet 26:e31–e32 CrossRefPubMed
33.
Zurück zum Zitat Shrivastava P, Kushwaha KPS, Kumawat RK, Chauhan T, Saiz M, Lorente JA, Batham MS, Singh SS, Chaubey G (2020) Untangled the genetic structure of Kahar and Tharu, using 23 Y chromosomal paternal lineage markers. Meta Gene 26:100797 CrossRef Shrivastava P, Kushwaha KPS, Kumawat RK, Chauhan T, Saiz M, Lorente JA, Batham MS, Singh SS, Chaubey G (2020) Untangled the genetic structure of Kahar and Tharu, using 23 Y chromosomal paternal lineage markers. Meta Gene 26:100797 CrossRef
34.
Zurück zum Zitat Singh M, Sarkar A, Nandineni MR (2018) A comprehensive portrait of Y‑STR diversity of Indian populations and comparison with 129 worldwide populations. Sci Rep 8(1):1–7 CrossRef Singh M, Sarkar A, Nandineni MR (2018) A comprehensive portrait of Y‑STR diversity of Indian populations and comparison with 129 worldwide populations. Sci Rep 8(1):1–7 CrossRef
37.
Zurück zum Zitat Takezaki N, Nei M, Tamura K (2009) POPTREE2: software for constructing population trees from allele frequency data and computing other population statistics with windows-interface. Mol Biol Evol 27(4):747–752 CrossRefPubMedPubMedCentral Takezaki N, Nei M, Tamura K (2009) POPTREE2: software for constructing population trees from allele frequency data and computing other population statistics with windows-interface. Mol Biol Evol 27(4):747–752 CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Watahiki H, Fujii K, Fukagawa T, Mita Y, Kitayama T, Mizuno N (2019) Polymorphisms and microvariant sequences in the Japanese population for 25 Y‑STR markers and their relationships to Y‑chromosome haplogroups. Forensic Sci Int Genet 41:e1–e7 CrossRefPubMed Watahiki H, Fujii K, Fukagawa T, Mita Y, Kitayama T, Mizuno N (2019) Polymorphisms and microvariant sequences in the Japanese population for 25 Y‑STR markers and their relationships to Y‑chromosome haplogroups. Forensic Sci Int Genet 41:e1–e7 CrossRefPubMed
40.
Zurück zum Zitat Xu C, Wei W, Zuo M, Zuo W, Li K, Lian X, Wang S, Zhou X, Zhang X, Zhong S (2023) Genetic polymorphisms and phylogenetic characteristics of Tibeto-Burman-speaking Lahu population from Southwest China based on 41 Y‑STR loci. Ann Hum Biol 50(1):75–81 CrossRefPubMed Xu C, Wei W, Zuo M, Zuo W, Li K, Lian X, Wang S, Zhou X, Zhang X, Zhong S (2023) Genetic polymorphisms and phylogenetic characteristics of Tibeto-Burman-speaking Lahu population from Southwest China based on 41 Y‑STR loci. Ann Hum Biol 50(1):75–81 CrossRefPubMed
41.
Zurück zum Zitat Yadav B, Raina A, Dogra TD (2010) Genetic polymorphisms for 17 Y‑chromosomal STR haplotypes in Jammu and Kashmir Saraswat Brahmin population. Leg Med 12(5):249–255 CrossRef Yadav B, Raina A, Dogra TD (2010) Genetic polymorphisms for 17 Y‑chromosomal STR haplotypes in Jammu and Kashmir Saraswat Brahmin population. Leg Med 12(5):249–255 CrossRef
42.
Zurück zum Zitat Yadav B, Raina A, Dogra TD (2011) Haplotype diversity of 17 Y‑chromosomal STRs in Saraswat Brahmin community of North India. Forensic Sci Int Genet 5(3):e63–e70 CrossRefPubMed Yadav B, Raina A, Dogra TD (2011) Haplotype diversity of 17 Y‑chromosomal STRs in Saraswat Brahmin community of North India. Forensic Sci Int Genet 5(3):e63–e70 CrossRefPubMed
43.
Zurück zum Zitat Yong RYY, Lee LKH, Yap EPH (2006) Y‑chromosome STR haplotype diversity in three ethnic populations in Singapore. Forensic Sci Int 159(2-3):244–257 CrossRefPubMed Yong RYY, Lee LKH, Yap EPH (2006) Y‑chromosome STR haplotype diversity in three ethnic populations in Singapore. Forensic Sci Int 159(2-3):244–257 CrossRefPubMed
Metadaten
Titel
Genetic portrait of 23 Y-STR loci in the Brahmin population of Haryana, India
verfasst von
Shivkant Sharma
Ritu Yadav
Vivek Sahajpal
Martin Zieger
Shalu Ranga
Parul Ahuja
Chetna Yadav
Mukesh Tanwar
Lokesh Kadian
Preeti Chauhan
Publikationsdatum
10.07.2023
Verlag
Springer Medizin
Erschienen in
Rechtsmedizin / Ausgabe 5/2023
Print ISSN: 0937-9819
Elektronische ISSN: 1434-5196
DOI
https://doi.org/10.1007/s00194-023-00634-z

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