nach oben

Current Fungal Infection Reports

Erschienen in:

28.06.2019 | Fungal Genomics and Pathogenesis (S Shoham, Section Editor)

Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis

verfasst von: Daniela Antunes, Cristina Cunha, Agostinho Carvalho

Erschienen in: Current Fungal Infection Reports | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

There is significant interindividual variability in the development and progression of fungal diseases, most notably invasive pulmonary aspergillosis (IPA). The integration of individual traits into clinically valid procedures to predict the risk and progression of infection, and the efficacy of antifungal prophylaxis and therapy, will change the current healthcare landscape regarding the management of patients at risk of IPA and, likely, other fungal infections.

Recent Findings

Over the last decade, an expanding number of common polymorphisms associated with IPA have been reported, adding to the information available on monogenic defects underlying severe forms of the disease. Predisposition to IPA is therefore nowadays considered to result from a combination of clinical and host factors, with the latter being most likely regulated at the genetic level.

Summary

In this review, we address the contribution of the genetic profile of the host to the outcome of the host-fungus interaction and discuss the application of this information in potential strategies with the aim of moving towards personalized prognostics, diagnostics, and treatment.

Segal BH. Aspergillosis. N Engl J Med. 2009;360(18):1870–84. https://doi.org/10.1056/NEJMra0808853.CrossRefPubMed

Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. Hidden killers: human fungal infections. Sci Transl Med. 2012;4(165):165rv113. https://doi.org/10.1126/scitranslmed.3004404.CrossRef

Kosmidis C, Denning DW. The clinical spectrum of pulmonary aspergillosis. Thorax. 2015;70(3):270–7. https://doi.org/10.1136/thoraxjnl-2014-206291.CrossRefPubMed

Campos CF, van de Veerdonk FL, Goncalves SM, Cunha C, Netea MG, Carvalho A. Host genetic signatures of susceptibility to fungal disease. Curr Top Microbiol Immunol. 2018. https://doi.org/10.1007/82_2018_113.

Cunha C, Aversa F, Romani L, Carvalho A. Human genetic susceptibility to invasive aspergillosis. PLoS Pathog. 2013;9(8):e1003434. https://doi.org/10.1371/journal.ppat.1003434.CrossRefPubMedPubMedCentral

Cunha C, Carvalho A. Genetic defects in fungal recognition and susceptibility to invasive pulmonary aspergillosis. Med Mycol. 2019;57(Supplement_2):S211–8. https://doi.org/10.1093/mmy/myy057.CrossRefPubMed

Durrant C, Tayem H, Yalcin B, Cleak J, Goodstadt L, de Villena FP, et al. Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection. Genome Res. 2011;21(8):1239–48. https://doi.org/10.1101/gr.118786.110.CrossRefPubMedPubMedCentral

•• Lionakis MS, Levitz SM. Host control of fungal infections: lessons from basic studies and human cohorts. Annu Rev Immunol. 2018;36:157–91. https://doi.org/10.1146/annurev-immunol-042617-053318 Excellent review on the factors underlying susceptibility to fungal disease in the context of both primary and acquired immunodeficiencies. CrossRefPubMed

Bertuzzi M, Hayes GE, Icheoku UJ, van Rhijn N, Denning DW, Osherov N, et al. Anti-Aspergillus activities of the respiratory epithelium in health and disease. J Fungi (Basel). 2018;4(1):E8.

10.

• Gago S, Overton NLD, Ben-Ghazzi N, Novak-Frazer L, Read ND, Denning DW, et al. Lung colonization by Aspergillus fumigatus is controlled by ZNF77. Nat Commun. 2018;9(1):3835. https://doi.org/10.1038/s41467-018-06148-7 A study describing genetic variation in the ZNF77 transcription factor as a risk factor for ABPA as the result of compromised integrity and function of the bronchial epithelium. CrossRefPubMedPubMedCentral

11.

Liu H, Lee MJ, Solis NV, Phan QT, Swidergall M, Ralph B, et al. Aspergillus fumigatus CalA binds to integrin alpha5beta1 and mediates host cell invasion. Nat Microbiol. 2016;2:16211. https://doi.org/10.1038/nmicrobiol.2016.211.CrossRefPubMedPubMedCentral

12.

Richard N, Marti L, Varrot A, Guillot L, Guitard J, Hennequin C, et al. Human bronchial epithelial cells inhibit Aspergillus fumigatus germination of extracellular conidia via FleA recognition. Sci Rep. 2018;8(1):15699. https://doi.org/10.1038/s41598-018-33902-0.CrossRefPubMedPubMedCentral

13.

• van de Veerdonk FL, Gresnigt MS, Romani L, Netea MG, Latge JP. Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol. 2017;15(11):661–74. https://doi.org/10.1038/nrmicro.2017.90 Extensive review on the fungal and host factors that regulate the outcome of infections by A. fumigatus . CrossRefPubMed

14.

Patin EC, Thompson A, Orr SJ. Pattern recognition receptors in fungal immunity. Semin Cell Dev Biol. 2018;89:24–33. https://doi.org/10.1016/j.semcdb.2018.03.003.CrossRefPubMed

15.

Bidula S, Schelenz S. A sweet response to a sour situation: the role of soluble pattern recognition receptors in the innate immune response to invasive Aspergillus fumigatus infections. PLoS Pathog. 2016;12(7):e1005637. https://doi.org/10.1371/journal.ppat.1005637.CrossRefPubMedPubMedCentral

16.

Carvalho A, Cunha C, Pasqualotto AC, Pitzurra L, Denning DW, Romani L. Genetic variability of innate immunity impacts human susceptibility to fungal diseases. Int J Infect Dis. 2010;14(6):e460–8. https://doi.org/10.1016/j.ijid.2009.06.028.CrossRefPubMed

17.

Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, et al. Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. Hum Mol Genet. 2013;22(23):4829–40. https://doi.org/10.1093/hmg/ddt335.CrossRefPubMedPubMedCentral

18.

Cunha C, Romani L, Carvalho A. Cracking the Toll-like receptor code in fungal infections. Expert Rev Anti-Infect Ther. 2010;8(10):1121–37. https://doi.org/10.1586/eri.10.93.CrossRefPubMed

19.

Bochud PY, Chien JW, Marr KA, Leisenring WM, Upton A, Janer M, et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med. 2008;359(17):1766–77. https://doi.org/10.1056/NEJMoa0802629.CrossRefPubMedPubMedCentral

20.

de Boer MG, Jolink H, Halkes CJ, van der Heiden PL, Kremer D, Falkenburg JH, et al. Influence of polymorphisms in innate immunity genes on susceptibility to invasive aspergillosis after stem cell transplantation. PLoS One. 2011;6(4):e18403. https://doi.org/10.1371/journal.pone.0018403.CrossRefPubMedPubMedCentral

21.

Koldehoff M, Beelen DW, Elmaagacli AH. Increased susceptibility for aspergillosis and post-transplant immune deficiency in patients with gene variants of TLR4 after stem cell transplantation. Transpl Infect Dis. 2013;15(5):533–9. https://doi.org/10.1111/tid.12115.CrossRefPubMed

22.

Carvalho A, Pasqualotto AC, Pitzurra L, Romani L, Denning DW, Rodrigues F. Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. J Infect Dis. 2008;197(4):618–21. https://doi.org/10.1086/526500.CrossRefPubMed

23.

Carvalho A, Cunha C, Carotti A, Aloisi T, Guarrera O, Di Ianni M, et al. Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation. Exp Hematol. 2009;37(9):1022–9. https://doi.org/10.1016/j.exphem.2009.06.004.CrossRefPubMed

24.

•• Fisher CE, Hohl TM, Fan W, Storer BE, Levine DM, Zhao LP, et al. Validation of single nucleotide polymorphisms in invasive aspergillosis following hematopoietic cell transplantation. Blood. 2017;129(19):2693–701. https://doi.org/10.1182/blood-2016-10-743294 A large-scale study that validated the association of genetic variants in PTX3 and dectin-1 with the risk of aspergillosis after stem cell transplantation. CrossRefPubMedPubMedCentral

25.

Kesh S, Mensah NY, Peterlongo P, Jaffe D, Hsu K, M VDB, et al. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci. 2005;1062:95–103. https://doi.org/10.1196/annals.1358.012.CrossRefPubMed

26.

Grube M, Loeffler J, Mezger M, Kruger B, Echtenacher B, Hoffmann P, et al. TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. Med Mycol. 2013;51(8):818–25. https://doi.org/10.3109/13693786.2013.809630.CrossRefPubMed

27.

Carvalho A, De Luca A, Bozza S, Cunha C, D’Angelo C, Moretti S, et al. TLR3 essentially promotes protective class I-restricted memory CD8(+) T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients. Blood. 2012;119(4):967–77. https://doi.org/10.1182/blood-2011-06-362582.CrossRefPubMed

28.

Overton NL, Simpson A, Bowyer P, Denning DW. Genetic susceptibility to severe asthma with fungal sensitization. Int J Immunogenet. 2017;44(3):93–106. https://doi.org/10.1111/iji.12312.CrossRefPubMed

29.

Cunha C, Giovannini G, Pierini A, Bell AS, Sorci G, Riuzzi F, et al. Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients. PLoS One. 2011;6(11):e27962. https://doi.org/10.1371/journal.pone.0027962.CrossRefPubMedPubMedCentral

30.

Brown GD, Willment JA, Whitehead L. C-type lectins in immunity and homeostasis. Nat Rev Immunol. 2018;18:374–89. https://doi.org/10.1038/s41577-018-0004-8.CrossRefPubMed

31.

Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, Venselaar H, et al. Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med. 2009;361(18):1760–7. https://doi.org/10.1056/NEJMoa0901053.CrossRefPubMedPubMedCentral

32.

Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol. 2007;8(1):31–8. https://doi.org/10.1038/ni1408.CrossRefPubMed

33.

• Cunha C, Di Ianni M, Bozza S, Giovannini G, Zagarella S, Zelante T, et al. Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood. 2010;116(24):5394–402. https://doi.org/10.1182/blood-2010-04-279307 The first report describing the requisite role of dectin-1 and the impact of its deficiency in both hematopoietic and non-hematopoietic compartments to antifungal immunity. CrossRefPubMed

34.

Chai LY, de Boer MG, van der Velden WJ, Plantinga TS, van Spriel AB, Jacobs C, et al. The Y238X stop codon polymorphism in the human beta-glucan receptor dectin-1 and susceptibility to invasive aspergillosis. J Infect Dis. 2011;203(5):736–43. https://doi.org/10.1093/infdis/jiq102.

35.

Fischer M, Spies-Weisshart B, Schrenk K, Gruhn B, Wittig S, Glaser A, et al. Polymorphisms of dectin-1 and TLR2 predispose to invasive fungal disease in patients with acute myeloid leukemia. PLoS One. 2016;11(3):e0150632. https://doi.org/10.1371/journal.pone.0150632.CrossRefPubMedPubMedCentral

36.

Sainz J, Lupianez CB, Segura-Catena J, Vazquez L, Rios R, Oyonarte S, et al. Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary aspergillosis infection. PLoS One. 2012;7(2):e32273. https://doi.org/10.1371/journal.pone.0032273.CrossRefPubMedPubMedCentral

37.

Carvalho A, Giovannini G, De Luca A, D’Angelo C, Casagrande A, Iannitti RG, et al. Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis. Cell Mol Immunol. 2012;9(3):276–86. https://doi.org/10.1038/cmi.2012.1.CrossRefPubMedPubMedCentral

38.

Fischer M, Muller JP, Spies-Weisshart B, Grafe C, Kurzai O, Hunniger K, et al. Isoform localization of dectin-1 regulates the signaling quality of anti-fungal immunity. Eur J Immunol. 2017;47(5):848–59. https://doi.org/10.1002/eji.201646849.CrossRefPubMed

39.

Netea MG, van der Meer JW. Trained immunity: an ancient way of remembering. Cell Host Microbe. 2017;21(3):297–300. https://doi.org/10.1016/j.chom.2017.02.003.CrossRefPubMed

40.

Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, et al. Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity. Cell Metab. 2016;24(6):807–19. https://doi.org/10.1016/j.cmet.2016.10.008.CrossRefPubMedPubMedCentral

41.

Bekkering S, Arts RJW, Novakovic B, Kourtzelis I, van der Heijden C, Li Y, et al. Metabolic induction of trained immunity through the mevalonate pathway. Cell. 2018;172(1–2):135–46 e139. https://doi.org/10.1016/j.cell.2017.11.025.CrossRefPubMed

42.

•• Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, et al. mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345(6204):1250684. https://doi.org/10.1126/science.1250684 The first demonstration that induction of innate immune memory—trained immunity—requires the metabolic reprogramming of immune cells. CrossRefPubMedPubMedCentral

43.

Dominguez-Andres J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, et al. The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity. Cell Metab. 2018;29:211–220.e5. https://doi.org/10.1016/j.cmet.2018.09.003.CrossRefPubMed

44.

•• Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, et al. Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature. 2018;555(7696):382–6. https://doi.org/10.1038/nature25974 A study that identified MelLec as a novel receptor for DHN-melanin from A. fumigatus and that characterized genetic variation in MelLec as a key risk factor for aspergillosis. CrossRef

45.

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, et al. Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity. Cell Host Microbe. 2016;19(1):79–90. https://doi.org/10.1016/j.chom.2015.12.002.CrossRefPubMed

46.

• Kyrmizi I, Ferreira H, Carvalho A, Figueroa JAL, Zarmpas P, Cunha C, et al. Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis. Nat Microbiol. 2018;3(7):791–803. https://doi.org/10.1038/s41564-018-0167-x A study that revealed calcium signaling as a major molecular mechanism activating LC3-associated phagocytosis and fungal clearance by immune cells. CrossRefPubMed

47.

Casadevall A. Melanin triggers antifungal defences. Nature. 2018;555(7696):319–20. https://doi.org/10.1038/d41586-018-02370-x.CrossRefPubMed

48.

Glocker EO, Hennigs A, Nabavi M, Schaffer AA, Woellner C, Salzer U, et al. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med. 2009;361(18):1727–35. https://doi.org/10.1056/NEJMoa0810719.CrossRefPubMedPubMedCentral

49.

Rieber N, Gazendam RP, Freeman AF, Hsu AP, Collar AL, Sugui JA, et al. Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. JCI Insight. 2016;1(17):e89890. https://doi.org/10.1172/jci.insight.89890.CrossRefPubMedPubMedCentral

50.

Xu X, Xu JF, Zheng G, Lu HW, Duan JL, Rui W, et al. CARD9(S12N) facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses. Nat Immunol. 2018;19:547–60. https://doi.org/10.1038/s41590-018-0112-4.CrossRefPubMed

51.

Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, et al. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nat Microbiol. 2018;4:316–27. https://doi.org/10.1038/s41564-018-0298-0.CrossRefPubMedPubMedCentral

52.

Karki R, Man SM, Malireddi RK, Gurung P, Vogel P, Lamkanfi M, et al. Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. Cell Host Microbe. 2015;17(3):357–68. https://doi.org/10.1016/j.chom.2015.01.006.CrossRefPubMedPubMedCentral

53.

Caruso R, Warner N, Inohara N, Nunez G. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity. 2014;41(6):898–908. https://doi.org/10.1016/j.immuni.2014.12.010.CrossRefPubMedPubMedCentral

54.

• Gresnigt MS, Cunha C, Jaeger M, Gonçalves SM, Subbarao Malireddi RK, Ammerdorfer A, et al. Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nat Commun. 2018;9:2636. https://doi.org/10.1038/s41467-018-04912-3 A study illustrating the involvement of NOD2 and its genetic variation in antifungal immunity and the development of aspergillosis. CrossRefPubMedPubMedCentral

55.

Foo SS, Reading PC, Jaillon S, Mantovani A, Mahalingam S. Pentraxins and collectins: friend or foe during pathogen invasion? Trends Microbiol. 2015;23(12):799–811. https://doi.org/10.1016/j.tim.2015.09.006.CrossRefPubMed

56.

Lambourne J, Agranoff D, Herbrecht R, Troke PF, Buchbinder A, Willis F, et al. Association of mannose-binding lectin deficiency with acute invasive aspergillosis in immunocompromised patients. Clin Infect Dis. 2009;49(10):1486–91. https://doi.org/10.1086/644619.CrossRefPubMed

57.

Crosdale DJ, Poulton KV, Ollier WE, Thomson W, Denning DW. Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. J Infect Dis. 2001;184(5):653–6. https://doi.org/10.1086/322791.CrossRefPubMed

58.

Vaid M, Kaur S, Sambatakou H, Madan T, Denning DW, Sarma PU. Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Clin Chem Lab Med. 2007;45(2):183–6. https://doi.org/10.1515/CCLM.2007.033.CrossRefPubMed

59.

Saxena S, Madan T, Shah A, Muralidhar K, Sarma PU. Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol. 2003;111(5):1001–7.CrossRef

60.

Madan T, Eggleton P, Kishore U, Strong P, Aggrawal SS, Sarma PU, et al. Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun. 1997;65(8):3171–9.PubMedPubMedCentral

61.

Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R, et al. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 2002;420(6912):182–6. https://doi.org/10.1038/nature01195.CrossRefPubMed

62.

•• Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, et al. Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med. 2014;370(5):421–32. https://doi.org/10.1056/NEJMoa1211161 A study demonstrating the pivotal contribution of genetic variation in PTX3 to aspergillosis as the result of impaired antifungal effector functions of neutrophils. CrossRefPubMed

63.

Cunha C, Monteiro AA, Oliveira-Coelho A, Kuhne J, Rodrigues F, Sasaki SD, et al. PTX3-based genetic testing for risk of aspergillosis after lung transplant. Clin Infect Dis. 2015;61(12):1893–4. https://doi.org/10.1093/cid/civ679.CrossRefPubMed

64.

Wojtowicz A, Lecompte TD, Bibert S, Manuel O, Rueger S, Berger C, et al. PTX3 polymorphisms and invasive mold infections after solid organ transplant. Clin Infect Dis. 2015;61(4):619–22. https://doi.org/10.1093/cid/civ386.CrossRefPubMed

65.

Cunha C, Carvalho A. Toward the identification of a genetic risk signature for pulmonary aspergillosis in chronic obstructive pulmonary disease. Clin Infect Dis. 2018;66(7):1153–4. https://doi.org/10.1093/cid/cix944.CrossRefPubMed

66.

He Q, Li H, Rui Y, Liu L, He B, Shi Y, et al. Pentraxin 3 gene polymorphisms and pulmonary aspergillosis in chronic obstructive pulmonary disease patients. Clin Infect Dis. 2018;66(2):261–7. https://doi.org/10.1093/cid/cix749.CrossRefPubMed

67.

Brunel AS, Wojtowicz A, Lamoth F, Spertini O, Neofytos D, Calandra T, et al. Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy. Haematologica. 2018;103(11):e527–30. https://doi.org/10.3324/haematol.2018.195453.CrossRefPubMedPubMedCentral

68.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, Garcia-Escudero R, et al. The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells. J Exp Med. 2016;213(10):2167–85. https://doi.org/10.1084/jem.20150282.CrossRefPubMedPubMedCentral

69.

Bozza S, Campo S, Arseni B, Inforzato A, Ragnar L, Bottazzi B, et al. PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis. J Immunol. 2014;193(5):2340–8. https://doi.org/10.4049/jimmunol.1400814.CrossRefPubMed

70.

Mauri T, Coppadoro A, Bombino M, Bellani G, Zambelli V, Fornari C, et al. Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia: a threshold-finding prospective observational study. Crit Care. 2014;18(5):562. https://doi.org/10.1186/s13054-014-0562-5.CrossRefPubMedPubMedCentral

71.

Gonçalves SM, Lagrou K, Rodrigues CS, Campos CF, Bernal-Martínez L, Rodrigues F, et al. Evaluation of bronchoalveolar lavage fluid cytokines as biomarkers for invasive pulmonary aspergillosis in at-risk patients. Front Microbiol. 2017;8:2362. https://doi.org/10.3389/fmicb.2017.02362.CrossRefPubMedPubMedCentral

72.

Carvalho A, Cunha C, Bistoni F, Romani L. Immunotherapy of aspergillosis. Clin Microbiol Infect. 2012;18(2):120–5. https://doi.org/10.1111/j.1469-0691.2011.03681.x.CrossRefPubMed

73.

Zaas AK, Liao G, Chien JW, Weinberg C, Shore D, Giles SS, et al. Plasminogen alleles influence susceptibility to invasive aspergillosis. PLoS Genet. 2008;4(6):e1000101. https://doi.org/10.1371/journal.pgen.1000101.CrossRefPubMedPubMedCentral

74.

Carvalho A, Cunha C, Di Ianni M, Pitzurra L, Aloisi T, Falzetti F, et al. Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation. Bone Marrow Transplant. 2010;45(11):1645–52. https://doi.org/10.1038/bmt.2010.28.CrossRefPubMed

75.

Lupianez CB, Canet LM, Carvalho A, Alcazar-Fuoli L, Springer J, Lackner M, et al. Polymorphisms in host immunity-modulating genes and risk of invasive aspergillosis: results from the AspBIOmics consortium. Infect Immun. 2015;84(3):643–57. https://doi.org/10.1128/IAI.01359-15.CrossRefPubMed

76.

Sainz J, Hassan L, Perez E, Romero A, Moratalla A, Lopez-Fernandez E, et al. Interleukin-10 promoter polymorphism as risk factor to develop invasive pulmonary aspergillosis. Immunol Lett. 2007;109(1):76–82. https://doi.org/10.1016/j.imlet.2007.01.005.CrossRefPubMed

77.

Sainz J, Perez E, Gomez-Lopera S, Jurado M. IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level. J Clin Immunol. 2008;28(5):473–85. https://doi.org/10.1007/s10875-008-9197-0.CrossRefPubMed

78.

Sainz J, Perez E, Hassan L, Moratalla A, Romero A, Collado MD, et al. Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis. Hum Immunol. 2007;68(1):41–50. https://doi.org/10.1016/j.humimm.2006.10.011.CrossRefPubMed

79.

Rodland EK, Ueland T, Bjornsen S, Sagen EL, Dahl CP, Naalsund A, et al. Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis. BMC Infect Dis. 2012;12:144. https://doi.org/10.1186/1471-2334-12-144.CrossRefPubMedPubMedCentral

80.

Roilides E, Sein T, Roden M, Schaufele RL, Walsh TJ. Elevated serum concentrations of interleukin-10 in nonneutropenic patients with invasive aspergillosis. J Infect Dis. 2001;183(3):518–20. https://doi.org/10.1086/318077.CrossRefPubMed

81.

Brouard J, Knauer N, Boelle PY, Corvol H, Henrion-Caude A, Flamant C, et al. Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis. J Infect Dis. 2005;191(11):1988–91. https://doi.org/10.1086/429964.CrossRefPubMed

82.

Seo KW, Kim DH, Sohn SK, Lee NY, Chang HH, Kim SW, et al. Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation. Bone Marrow Transplant. 2005;36(12):1089–95. https://doi.org/10.1038/sj.bmt.1705181.CrossRefPubMed

83.

Cunha C, Goncalves SM, Duarte-Oliveira C, Leite L, Lagrou K, Marques A, et al. IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity. J Allergy Clin Immunol. 2017;140(3):867–70 e869. https://doi.org/10.1016/j.jaci.2017.02.034.CrossRefPubMed

84.

Wojtowicz A, Gresnigt MS, Lecompte T, Bibert S, Manuel O, Joosten LA, et al. IL1B and DEFB1 polymorphisms increase susceptibility to invasive mold infection after solid-organ transplantation. J Infect Dis. 2015;211(10):1646-57.

85.

Mezger M, Steffens M, Beyer M, Manger C, Eberle J, Toliat MR, et al. Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells. Blood. 2008;111(2):534–6. https://doi.org/10.1182/blood-2007-05-090928.CrossRefPubMed

86.

Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, et al. Immunotherapeutic approaches to treatment of fungal diseases. Lancet Infect Dis. 2017;17(12):e393–402. https://doi.org/10.1016/S1473-3099(17)30442-5.CrossRefPubMed

87.

Hope WW, Walsh TJ, Denning DW. Laboratory diagnosis of invasive aspergillosis. Lancet Infect Dis. 2005;5(10):609–22. https://doi.org/10.1016/S1473-3099(05)70238-3.CrossRefPubMed

88.

Oliveira-Coelho A, Rodrigues F, Campos A Jr, Lacerda JF, Carvalho A, Cunha C. Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis. Front Microbiol. 2015;6:411. https://doi.org/10.3389/fmicb.2015.00411.CrossRefPubMedPubMedCentral

89.

White PL, Parr C, Barnes RA. Predicting invasive aspergillosis in hematology patients by combining clinical and genetic risk factors with early diagnostic biomarkers. J Clin Microbiol. 2018;56(1). https://doi.org/10.1128/JCM.01122-17.

Titel: Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
verfasst von: Daniela Antunes
Cristina Cunha
Agostinho Carvalho
Publikationsdatum: 28.06.2019
Verlag: Springer US
Erschienen in: Current Fungal Infection Reports / Ausgabe 3/2019
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI: https://doi.org/10.1007/s12281-019-00344-8

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Nierenkarzinom | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis

Abstract

Purpose of Review

Recent Findings

Summary

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Adjuvante Immuntherapie verlängert Leben bei RCC

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Update Innere Medizin

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2019

(New) Methods for Detection of Aspergillus fumigatus Resistance in Clinical Samples

Correction to: (New) Methods for Detection of Aspergillus fumigatus Resistance in Clinical Samples

Histoplasmosis: Epidemiology, Diagnosis, and Clinical Manifestations

Clinical Aspects of Immune Damage in Cryptococcosis

Cryptococcal Pathogenicity and Morphogenesis

Fungal Infections with Ibrutinib and Other Small-Molecule Kinase Inhibitors

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Adjuvante Immuntherapie verlängert Leben bei RCC

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Update Innere Medizin