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Erschienen in: Brain Structure and Function 8/2016

14.12.2015 | Short Communication

Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review

verfasst von: Jordan E. Wong, Jinyan Cao, David M. Dorris, John Meitzen

Erschienen in: Brain Structure and Function | Ausgabe 8/2016

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Abstract

Sex differences are widespread across vertebrate nervous systems. Such differences are sometimes reflected in the neural substrate via neuroanatomical differences in brain region volume. One brain region that displays sex differences in its associated functions and pathologies is the striatum, including the caudate-putamen (dorsal striatum), nucleus accumbens core and shell (ventral striatum). The extent to which these differences can be attributed to alterations in volume is unclear. We thus tested whether the volumes of the caudate-putamen, nucleus accumbens core, and nucleus accumbens shell differed by region, sex, and hemisphere in adult Sprague–Dawley rats. As a positive control for detecting sex differences in brain region volume, we measured the sexually dimorphic nucleus of the medial preoptic area (SDN-POA). As expected, SDN-POA volume was larger in males than in females. No sex differences were detected in the volumes of the caudate-putamen, nucleus accumbens core or shell. Nucleus accumbens core volume was larger in the right than left hemisphere across males and females. These findings complement previous reports of lateralized nucleus accumbens volume in humans, and suggest that this may possibly be driven via hemispheric differences in nucleus accumbens core volume. In contrast, striatal sex differences seem to be mediated by factors other than striatal region volume. This conclusion is presented within the context of a detailed review of studies addressing sex differences and similarities in striatal neuroanatomy.
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Metadaten
Titel
Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review
verfasst von
Jordan E. Wong
Jinyan Cao
David M. Dorris
John Meitzen
Publikationsdatum
14.12.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 8/2016
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-015-1158-9

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