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26.03.2020 | Population Data

Genetic structure and forensic characteristics of the Kyrgyz population from Kizilsu Kirghiz autonomous prefecture based on autosomal DIPs

verfasst von: Mingkun Xie, Ye Li, Jin Wu, Feng Song, Yang Lu, Lirong Liao, Jienan Li

Erschienen in: International Journal of Legal Medicine | Ausgabe 2/2022

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Abstract

Living in the heart of Eurasia, the Kyrgyz ethnic minority have a complex human evolutionary and migration history. However, the genetic architecture of the Kyrgyz population has not been fully explored. We studied 526 Kyrgyz samples from Kizilsu Kirghiz Autonomous Prefecture in Xinjiang using the Investigator® DIPplex kit. All loci followed Hardy-Weinberg equilibrium (HWE). The combined power of discrimination (CPD) and combined power of paternity exclusion (CPE) was 0.9999999999988 and 0.9936, respectively. Compared with 90 reference populations, five InDels (HLD99, HLD81, HLD64, HLD118, and HLD111) have the potential to distinguish the Kyrgyz/Uyghur/Kazak population from other East Asian populations. Our results suggested a close genetic relationship between the Kyrgyz population and the Uyghur/Kazak populations, followed by South Asian populations. This was in accordance with the inland migration hypothesis or modern human migration influenced by warfare. Overall, this system can be used as a powerful tool in forensic individual identification and as a complementary tool in paternity cases and biogeographic ancestry analyses.

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Feng QD, Lu Y, Ni XM, Yuan K, Yang YJ, Yang X, Liu C, Lou HY, Ning ZL, Wang YC, Lu DS, Zhang C, Zhou Y, Shi M, Tian L, Wang XJ, Zhang X, Li J, Khan A, Guan YQ, Tang K, Wang SJ, Xu SH (2017) Genetic history of Xinjiang's Uyghurs suggests bronze age multiple-way contacts in Eurasia. Mol Biol Evol 34(10):2572–2582. https://doi.org/10.1093/molbev/msx177CrossRefPubMed

Xie M, Song F, Li J, Lang M, Luo H, Wang Z, Wu J, Li C, Tian C, Wang W, Ma H, Song Z, Fan Y, Hou Y (2019) Genetic substructure and forensic characteristics of Chinese Hui populations using 157 Y-SNPs and 27 Y-STRs. Forensic Sci Int Genet 41:11–18. https://doi.org/10.1016/j.fsigen.2019.03.022CrossRefPubMed

Guo Y, Chen C, Xie T, Cui W, Meng H, Jin X, Zhu B (2018) Forensic efficiency estimate and phylogenetic analysis for Chinese Kyrgyz ethnic group revealed by a panel of 21 short tandem repeats. R Soc Open Sci 5(6):172089. https://doi.org/10.1098/rsos.172089CrossRefPubMedPubMedCentral

Peng MS, Xu WF, Song JJ, Chen X, Sulaiman X, Cai LH, Liu HQ, Wu SF, Gao Y, Abdulloevich NT, Afanasevna ME, Ibrohimovich KB, Chen X, Yang WK, Wu M, Li GM, Yang XY, Rakha A, Yao YG, Upur H, Zhang YP (2018) Mitochondrial genomes uncover the maternal history of the Pamir populations. Eur J Hum Genet 26(1):124–136. https://doi.org/10.1038/s41431-017-0028-8CrossRefPubMed

Zhan XN, Adnan A, Zhou YZ, Khan A, Kasim K, McNevin D (2018) Forensic characterization of 15 autosomal STRs in four populations from Xinjiang, China, and genetic relationships with neighboring populations. Sci Rep 8:4673. https://doi.org/10.1038/s41598-018-22975-6CrossRefPubMedPubMedCentral

Guo YX, Chen C, Jin XY, Cui W, Wei YY, Wang HD, Kong TT, Mu YL, Zhu BF (2018) Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group. Sci Rep 8:11054. https://doi.org/10.1038/s41598-018-29010-8CrossRefPubMedPubMedCentral

Guo YX, Chen C, Xie T, Cui W, Meng HT, Jin XY, Zhu BF (2018) Forensic efficiency estimate and phylogenetic analysis for Chinese Kyrgyz ethnic group revealed by a panel of 21 short tandem repeats. Roy Soc Open Sci 5(6):172089. https://doi.org/10.1098/rsos.172089CrossRef

Li Y, Li X, Chen WY, Fan YJ, Xie MK, Wu J (2019) Allele and haplotype frequencies of 19 X-STRs in the Kyrgyz and Han populations from Kizilsu prefecture. Forensic Sci Int-Gen 40:E259–E261. https://doi.org/10.1016/j.fsigen.2019.02.007CrossRef

Li Y, Li X, Chen W, Fan Y, Xie M, Wu J (2019) Allele and haplotype frequencies of 19 X-STRs in the Kyrgyz and Han populations from Kizilsu prefecture. Forensic Sci Int Genet 40:e259–e261. https://doi.org/10.1016/j.fsigen.2019.02.007CrossRefPubMed

10.

Excoffier L, Lischer HE (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and windows. Mol Ecol Resour 10(3):564–567. https://doi.org/10.1111/j.1755-0998.2010.02847.xCrossRefPubMed

11.

Kumar S, Stecher G, Tamura K (2016) MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 33(7):1870–1874. https://doi.org/10.1093/molbev/msw054CrossRefPubMedPubMedCentral

12.

Falush D, Stephens M, Pritchard JK (2007) Inference of population structure using multilocus genotype data: dominant markers and null alleles. Mol Ecol Notes 7(4):574–578. https://doi.org/10.1111/j.1471-8286.2007.01758.xCrossRefPubMedPubMedCentral

13.

He G, Wang Z, Wang M, Luo T, Liu J, Zhou Y, Gao B, Hou Y (2018) Forensic ancestry analysis in two Chinese minority populations using massively parallel sequencing of 165 ancestry-informative SNPs. Electrophoresis 39(21):2732–2742. https://doi.org/10.1002/elps.201800019CrossRefPubMed

14.

Underhill PA, Passarino G, Lin AA, Shen P, Mirazon Lahr M, Foley RA, Oefner PJ, Cavalli-Sforza LL (2001) The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. Ann Hum Genet 65(Pt 1):43–62. https://doi.org/10.1046/j.1469-1809.2001.6510043.xCrossRefPubMed

15.

Lou H, Li S, Jin W, Fu R, Lu D, Pan X, Zhou H, Ping Y, Jin L, Xu S (2015) Copy number variations and genetic admixtures in three Xinjiang ethnic minority groups. Eur J Hum Genet 23(4):536–542. https://doi.org/10.1038/ejhg.2014.134CrossRefPubMed

Titel: Genetic structure and forensic characteristics of the Kyrgyz population from Kizilsu Kirghiz autonomous prefecture based on autosomal DIPs
verfasst von: Mingkun Xie
Ye Li
Jin Wu
Feng Song
Yang Lu
Lirong Liao
Jienan Li
Publikationsdatum: 26.03.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Legal Medicine / Ausgabe 2/2022
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-020-02277-1

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Genetic structure and forensic characteristics of the Kyrgyz population from Kizilsu Kirghiz autonomous prefecture based on autosomal DIPs

Abstract

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